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20 similar compounds to monomer 50188913

Compile data set for download or QSAR
Wt: 407.3
BDBM50188912
Wt: 372.8
BDBM50188915
Wt: 465.3
BDBM50188916
Wt: 338.4
BDBM50188917
Wt: 435.3
BDBM50188918
Wt: 421.3
BDBM50188923
Wt: 450.3
BDBM50188927
Wt: 372.8
BDBM50188928
Wt: 464.4
BDBM50188929
Wt: 372.8
BDBM50188932
Wt: 422.3
BDBM50188933
Wt: 352.4
BDBM50188937
Wt: 435.3
BDBM50188938
Wt: 421.3
BDBM50188940
Wt: 436.3
BDBM50188941
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50188912,50188915,50188916,50188917,50188918,50188923,50188927,50188928,50188929,50188932,50188933,50188937,50188938,50188940,50188941   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188912
PNG
(CHEMBL209838 | N-(2,4-dichlorophenethyl)-5-(2-(met...)
Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)NCCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H16Cl2N4OS/c1-21-18-23-9-7-14(24-18)15-4-5-16(26-15)17(25)22-8-6-11-2-3-12(19)10-13(11)20/h2-5,7,9-10H,6,8H2,1H3,(H,22,25)(H,21,23,24)
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n/an/a 990n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188940
PNG
(CHEMBL212814 | N-(2,4-dichlorophenethyl)-5-(2-(dim...)
Show SMILES CN(C)c1nccc(n1)-c1ccc(s1)C(=O)NCCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H18Cl2N4OS/c1-25(2)19-23-10-8-15(24-19)16-5-6-17(27-16)18(26)22-9-7-12-3-4-13(20)11-14(12)21/h3-6,8,10-11H,7,9H2,1-2H3,(H,22,26)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188917
PNG
(5-(2-(methylamino)pyrimidin-4-yl)-N-phenethylthiop...)
Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C18H18N4OS/c1-19-18-21-12-10-14(22-18)15-7-8-16(24-15)17(23)20-11-9-13-5-3-2-4-6-13/h2-8,10,12H,9,11H2,1H3,(H,20,23)(H,19,21,22)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188916
PNG
((2S)-methyl 3-(2,4-dichlorophenyl)-2-(2-(2-(methyl...)
Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)OC
Show InChI InChI=1S/C20H18Cl2N4O3S/c1-23-20-24-8-7-14(26-20)16-5-6-17(30-16)18(27)25-15(19(28)29-2)9-11-3-4-12(21)10-13(11)22/h3-8,10,15H,9H2,1-2H3,(H,25,27)(H,23,24,26)/t15-/m0/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188918
PNG
(CHEMBL211570 | N-(2-(2,4-dichlorophenyl)butyl)-5-(...)
Show SMILES CCC(CNC(=O)c1ccc(s1)-c1ccnc(NC)n1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H20Cl2N4OS/c1-3-12(14-5-4-13(21)10-15(14)22)11-25-19(27)18-7-6-17(28-18)16-8-9-24-20(23-2)26-16/h4-10,12H,3,11H2,1-2H3,(H,25,27)(H,23,24,26)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188923
PNG
(CHEMBL211574 | N-(2,4-dichlorophenethyl)-5-(2-(eth...)
Show SMILES CCNc1nccc(n1)-c1ccc(s1)C(=O)NCCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H18Cl2N4OS/c1-2-22-19-24-10-8-15(25-19)16-5-6-17(27-16)18(26)23-9-7-12-3-4-13(20)11-14(12)21/h3-6,8,10-11H,2,7,9H2,1H3,(H,23,26)(H,22,24,25)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188927
PNG
(CHEMBL385143 | N-((S)-4-amino-1-(2,4-dichloropheny...)
Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@H](CCN)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H21Cl2N5OS/c1-24-20-25-9-7-16(27-20)17-4-5-18(29-17)19(28)26-14(6-8-23)10-12-2-3-13(21)11-15(12)22/h2-5,7,9,11,14H,6,8,10,23H2,1H3,(H,26,28)(H,24,25,27)/t14-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188929
PNG
(CHEMBL384964 | N-((S)-1-(2,4-dichlorophenyl)-3-(di...)
Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@H](CN(C)C)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H23Cl2N5OS/c1-24-21-25-9-8-17(27-21)18-6-7-19(30-18)20(29)26-15(12-28(2)3)10-13-4-5-14(22)11-16(13)23/h4-9,11,15H,10,12H2,1-3H3,(H,26,29)(H,24,25,27)/t15-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188928
PNG
(CHEMBL376004 | N-(4-chlorophenethyl)-5-(2-(methyla...)
Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN4OS/c1-20-18-22-11-9-14(23-18)15-6-7-16(25-15)17(24)21-10-8-12-2-4-13(19)5-3-12/h2-7,9,11H,8,10H2,1H3,(H,21,24)(H,20,22,23)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188933
PNG
(CHEMBL209952 | N-((S)-2-amino-2-(2,4-dichloropheny...)
Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)NC[C@@H](N)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H17Cl2N5OS/c1-22-18-23-7-6-14(25-18)15-4-5-16(27-15)17(26)24-9-13(21)11-3-2-10(19)8-12(11)20/h2-8,13H,9,21H2,1H3,(H,24,26)(H,22,23,25)/t13-/m1/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188932
PNG
(CHEMBL210071 | N-(2-chlorophenethyl)-5-(2-(methyla...)
Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)NCCc1ccccc1Cl
Show InChI InChI=1S/C18H17ClN4OS/c1-20-18-22-11-9-14(23-18)15-6-7-16(25-15)17(24)21-10-8-12-4-2-3-5-13(12)19/h2-7,9,11H,8,10H2,1H3,(H,21,24)(H,20,22,23)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188937
PNG
(5-(2-methylamino-pyrimidin-4-yl)-thiophene-2-carbo...)
Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)NCCc1ccc(C)cc1
Show InChI InChI=1S/C19H20N4OS/c1-13-3-5-14(6-4-13)9-11-21-18(24)17-8-7-16(25-17)15-10-12-22-19(20-2)23-15/h3-8,10,12H,9,11H2,1-2H3,(H,21,24)(H,20,22,23)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188941
PNG
(CHEMBL380165 | N-((R)-1-amino-3-(2,4-dichloropheny...)
Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@@H](CN)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H19Cl2N5OS/c1-23-19-24-7-6-15(26-19)16-4-5-17(28-16)18(27)25-13(10-22)8-11-2-3-12(20)9-14(11)21/h2-7,9,13H,8,10,22H2,1H3,(H,25,27)(H,23,24,26)/t13-/m1/s1
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n/an/a 240n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188938
PNG
(CHEMBL214070 | N-(2,4-dichlorophenethyl)-5-(2-(pro...)
Show SMILES CCCNc1nccc(n1)-c1ccc(s1)C(=O)NCCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H20Cl2N4OS/c1-2-9-24-20-25-11-8-16(26-20)17-5-6-18(28-17)19(27)23-10-7-13-3-4-14(21)12-15(13)22/h3-6,8,11-12H,2,7,9-10H2,1H3,(H,23,27)(H,24,25,26)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50188915
PNG
(CHEMBL378721 | N-(3-chlorophenethyl)-5-(2-(methyla...)
Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)NCCc1cccc(Cl)c1
Show InChI InChI=1S/C18H17ClN4OS/c1-20-18-22-10-8-14(23-18)15-5-6-16(25-15)17(24)21-9-7-12-3-2-4-13(19)11-12/h2-6,8,10-11H,7,9H2,1H3,(H,21,24)(H,20,22,23)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of AKT3 in presence of 0.2 uM ATP


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair