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8 similar compounds to monomer 16173

Wt: 273.6
BDBM50190473
Wt: 313.7
BDBM50190491
Wt: 341.8
BDBM50190492
Wt: 299.7
BDBM50270005
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Wt: 268.6
BDBM50356131
Wt: 282.6
BDBM50356133
Wt: 328.8
BDBM50356141
Wt: 214.6
BDBM50356118
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50190473,50190491,50190492,50270005,50356131,50356133,50356141,50356118   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50270005
PNG
(5'-(N-ethyl-N-isopropyl)amiloride | CHEMBL1909809 ...)
Show SMILES CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
Show InChI InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
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n/an/an/an/a 6.41E+4n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190473
PNG
(CHEMBL377688 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCO
Show InChI InChI=1S/C8H12ClN7O2/c9-4-6(11)15-5(10)3(14-4)7(18)16-8(12)13-1-2-17/h17H,1-2H2,(H4,10,11,15)(H3,12,13,16,18)
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PubMed
n/an/a 107n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


J Med Chem 49: 4098-115 (2006)

More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190491
PNG
(CHEMBL210966 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES CCCCCCN=C(N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C12H20ClN7O/c1-2-3-4-5-6-17-12(16)20-11(21)7-9(14)19-10(15)8(13)18-7/h2-6H2,1H3,(H4,14,15,19)(H3,16,17,20,21)
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Article
PubMed
n/an/a 87n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


J Med Chem 49: 4098-115 (2006)

More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel alpha-subunit


(Homo sapiens)
BDBM50190492
PNG
(CHEMBL210981 | N-(3,5-diamino-6-chloropyrazine-2-c...)
Show SMILES CCCCCCCCN=C(N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C14H24ClN7O/c1-2-3-4-5-6-7-8-19-14(18)22-13(23)9-11(16)21-12(17)10(15)20-9/h2-8H2,1H3,(H4,16,17,21)(H3,18,19,22,23)
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n/an/a 108n/an/an/an/an/an/a



Parion Sciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of dog bronchi prototypical epithelial sodium channel by electrophysiological assay


J Med Chem 49: 4098-115 (2006)

More data for this
Ligand-Target Pair
Sodium/hydrogen exchanger


(Amphiuma tridactylum)
BDBM50270005
PNG
(5'-(N-ethyl-N-isopropyl)amiloride | CHEMBL1909809 ...)
Show SMILES CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
Show InChI InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
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n/an/a 8.70E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Amphiuma tridactylum wild type NHE1 expressed in chinese hamster AP1 cells assessed as intracellular pHi recovery by ammonium chloride ...


J Biol Chem 282: 19716-27 (2007)

More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50270005
PNG
(5'-(N-ethyl-N-isopropyl)amiloride | CHEMBL1909809 ...)
Show SMILES CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
Show InChI InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
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n/an/a 6.00E+3n/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of urokinase-type plasminogen activator


Bioorg Med Chem Lett 21: 6760-6 (2011)

More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50356118
PNG
(CHEMBL1909778)
Show SMILES NC(=N)NC(=O)c1nc(Cl)cnc1N
Show InChI InChI=1S/C6H7ClN6O/c7-2-1-11-4(8)3(12-2)5(14)13-6(9)10/h1H,(H2,8,11)(H4,9,10,13,14)
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n/an/a>1.00E+6n/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of urokinase-type plasminogen activator


Bioorg Med Chem Lett 21: 6760-6 (2011)

More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50356131
PNG
(CHEMBL1909791)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(NCC#N)nc1N
Show InChI InChI=1S/C8H9ClN8O/c9-4-6(14-2-1-10)16-5(11)3(15-4)7(18)17-8(12)13/h2H2,(H3,11,14,16)(H4,12,13,17,18)
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of urokinase-type plasminogen activator


Bioorg Med Chem Lett 21: 6760-6 (2011)

More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50356133
PNG
(CHEMBL1909793)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(NCCC#N)nc1N
Show InChI InChI=1S/C9H11ClN8O/c10-5-7(15-3-1-2-11)17-6(12)4(16-5)8(19)18-9(13)14/h1,3H2,(H3,12,15,17)(H4,13,14,18,19)
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of urokinase-type plasminogen activator


Bioorg Med Chem Lett 21: 6760-6 (2011)

More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50356141
PNG
(CHEMBL1909801)
Show SMILES CCN(CC)CCNc1nc(N)c(nc1Cl)C(=O)NC(N)=N
Show InChI InChI=1S/C12H21ClN8O/c1-3-21(4-2)6-5-17-10-8(13)18-7(9(14)19-10)11(22)20-12(15)16/h3-6H2,1-2H3,(H3,14,17,19)(H4,15,16,20,22)
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Inhibition of urokinase-type plasminogen activator


Bioorg Med Chem Lett 21: 6760-6 (2011)

More data for this
Ligand-Target Pair
Sodium/hydrogen exchanger 1


(Homo sapiens)
BDBM50270005
PNG
(5'-(N-ethyl-N-isopropyl)amiloride | CHEMBL1909809 ...)
Show SMILES CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
Show InChI InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
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Article
PubMed
n/an/a 800n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of human wild type NHE1 expressed in chinese hamster AP1 cells assessed as intracellular pHi recovery by ammonium chloride prepulse protoc...


J Biol Chem 282: 19716-27 (2007)

More data for this
Ligand-Target Pair