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19 similar compounds to monomer 50191965

Compile data set for download or QSAR
Wt: 344.4
BDBM50191947
Wt: 348.3
BDBM50191948
Purchase
Wt: 348.3
BDBM50191949
Wt: 360.4
BDBM50191950
Wt: 348.3
BDBM50191951
Wt: 355.3
BDBM50191952
Wt: 364.8
BDBM50191954
Wt: 330.3
BDBM50191955
Wt: 364.8
BDBM50191956
Wt: 374.4
BDBM50191957
Wt: 360.4
BDBM50191958
Wt: 360.4
BDBM50191960
Wt: 376.4
BDBM50191961
Wt: 364.8
BDBM50191964
Wt: 302.3
BDBM50191966
Displayed 1 to 15 (of 19 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 60 hits for monomerid = 50191947,50191948,50191949,50191950,50191951,50191952,50191954,50191955,50191956,50191957,50191958,50191960,50191961,50191964,50191966   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GRIA2


(Homo sapiens (Human))
BDBM50191947
PNG
(4-cyano-5-ethyl-1-methyl-3-(4'-methyl-biphenyl-4-y...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(C)cc1
Show InChI InChI=1S/C22H20N2O2/c1-4-19-18(13-23)20(21(22(25)26)24(19)3)17-11-9-16(10-12-17)15-7-5-14(2)6-8-15/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 412n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191950
PNG
(4-cyano-5-ethyl-3-(3'-methoxy-biphenyl-4-yl)-1-met...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1cccc(OC)c1
Show InChI InChI=1S/C22H20N2O3/c1-4-19-18(13-23)20(21(22(25)26)24(19)2)15-10-8-14(9-11-15)16-6-5-7-17(12-16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 1.05E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191949
PNG
(4-cyano-5-ethyl-3-(3'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1cccc(F)c1
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)14-9-7-13(8-10-14)15-5-4-6-16(22)11-15/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 1.49E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191952
PNG
(4-cyano-3-(2'-cyano-biphenyl-4-yl)-5-ethyl-1-methy...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1C#N
Show InChI InChI=1S/C22H17N3O2/c1-3-19-18(13-24)20(21(22(26)27)25(19)2)15-10-8-14(9-11-15)17-7-5-4-6-16(17)12-23/h4-11H,3H2,1-2H3,(H,26,27)
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n/an/an/an/a 53n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191951
PNG
(4-cyano-5-ethyl-3-(4'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)15-6-4-13(5-7-15)14-8-10-16(22)11-9-14/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 1.04E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191950
PNG
(4-cyano-5-ethyl-3-(3'-methoxy-biphenyl-4-yl)-1-met...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1cccc(OC)c1
Show InChI InChI=1S/C22H20N2O3/c1-4-19-18(13-23)20(21(22(25)26)24(19)2)15-10-8-14(9-11-15)16-6-5-7-17(12-16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 924n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191954
PNG
(3-(2'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1Cl
Show InChI InChI=1S/C21H17ClN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 157n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191955
PNG
(3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrol...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H18N2O2/c1-3-18-17(13-22)19(20(21(24)25)23(18)2)16-11-9-15(10-12-16)14-7-5-4-6-8-14/h4-12H,3H2,1-2H3,(H,24,25)
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n/an/an/an/a 398n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191956
PNG
(3-(4'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)15-6-4-13(5-7-15)14-8-10-16(22)11-9-14/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 910n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191957
PNG
(4-cyano-3-(2'-ethoxy-biphenyl-4-yl)-5-ethyl-1-meth...)
Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1c(C#N)c(CC)n(C)c1C(O)=O
Show InChI InChI=1S/C23H22N2O3/c1-4-19-18(14-24)21(22(23(26)27)25(19)3)16-12-10-15(11-13-16)17-8-6-7-9-20(17)28-5-2/h6-13H,4-5H2,1-3H3,(H,26,27)
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n/an/an/an/a 146n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191958
PNG
(4-cyano-5-ethyl-3-(2'-methoxy-biphenyl-4-yl)-1-met...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1OC
Show InChI InChI=1S/C22H20N2O3/c1-4-18-17(13-23)20(21(22(25)26)24(18)2)15-11-9-14(10-12-15)16-7-5-6-8-19(16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 386n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191952
PNG
(4-cyano-3-(2'-cyano-biphenyl-4-yl)-5-ethyl-1-methy...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1C#N
Show InChI InChI=1S/C22H17N3O2/c1-3-19-18(13-24)20(21(22(26)27)25(19)2)15-10-8-14(9-11-15)17-7-5-4-6-16(17)12-23/h4-11H,3H2,1-2H3,(H,26,27)
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n/an/an/an/a 82n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191960
PNG
(4-cyano-5-ethyl-3-(4'-methoxy-biphenyl-4-yl)-1-met...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(OC)cc1
Show InChI InChI=1S/C22H20N2O3/c1-4-19-18(13-23)20(21(22(25)26)24(19)2)16-7-5-14(6-8-16)15-9-11-17(27-3)12-10-15/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 738n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191955
PNG
(3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrol...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H18N2O2/c1-3-18-17(13-22)19(20(21(24)25)23(18)2)16-11-9-15(10-12-16)14-7-5-4-6-8-14/h4-12H,3H2,1-2H3,(H,24,25)
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n/an/an/an/a 1.77E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191949
PNG
(4-cyano-5-ethyl-3-(3'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1cccc(F)c1
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)14-9-7-13(8-10-14)15-5-4-6-16(22)11-15/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 426n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191961
PNG
(4-cyano-5-ethyl-1-methyl-3-(2'-methylsulfanyl-biph...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1SC
Show InChI InChI=1S/C22H20N2O2S/c1-4-18-17(13-23)20(21(22(25)26)24(18)2)15-11-9-14(10-12-15)16-7-5-6-8-19(16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 77n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191961
PNG
(4-cyano-5-ethyl-1-methyl-3-(2'-methylsulfanyl-biph...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1SC
Show InChI InChI=1S/C22H20N2O2S/c1-4-18-17(13-23)20(21(22(25)26)24(18)2)15-11-9-14(10-12-15)16-7-5-6-8-19(16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 32n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191957
PNG
(4-cyano-3-(2'-ethoxy-biphenyl-4-yl)-5-ethyl-1-meth...)
Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1c(C#N)c(CC)n(C)c1C(O)=O
Show InChI InChI=1S/C23H22N2O3/c1-4-19-18(14-24)21(22(23(26)27)25(19)3)16-12-10-15(11-13-16)17-8-6-7-9-20(17)28-5-2/h6-13H,4-5H2,1-3H3,(H,26,27)
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n/an/an/an/a 83n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191951
PNG
(4-cyano-5-ethyl-3-(4'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)15-6-4-13(5-7-15)14-8-10-16(22)11-9-14/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 345n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191948
PNG
(4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 143n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191957
PNG
(4-cyano-3-(2'-ethoxy-biphenyl-4-yl)-5-ethyl-1-meth...)
Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1c(C#N)c(CC)n(C)c1C(O)=O
Show InChI InChI=1S/C23H22N2O3/c1-4-19-18(14-24)21(22(23(26)27)25(19)3)16-12-10-15(11-13-16)17-8-6-7-9-20(17)28-5-2/h6-13H,4-5H2,1-3H3,(H,26,27)
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n/an/an/an/a 36n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191961
PNG
(4-cyano-5-ethyl-1-methyl-3-(2'-methylsulfanyl-biph...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1SC
Show InChI InChI=1S/C22H20N2O2S/c1-4-18-17(13-23)20(21(22(25)26)24(18)2)15-11-9-14(10-12-15)16-7-5-6-8-19(16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 105n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191964
PNG
(3-(3'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)14-9-7-13(8-10-14)15-5-4-6-16(22)11-15/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191966
PNG
(3-biphenyl-4-yl-4-cyano-1-methyl-1H-pyrrole-2-carb...)
Show SMILES Cn1cc(C#N)c(c1C(O)=O)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H14N2O2/c1-21-12-16(11-20)17(18(21)19(22)23)15-9-7-14(8-10-15)13-5-3-2-4-6-13/h2-10,12H,1H3,(H,22,23)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191964
PNG
(3-(3'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)14-9-7-13(8-10-14)15-5-4-6-16(22)11-15/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 1.08E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191956
PNG
(3-(4'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)15-6-4-13(5-7-15)14-8-10-16(22)11-9-14/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 142n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191948
PNG
(4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 111n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191954
PNG
(3-(2'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1Cl
Show InChI InChI=1S/C21H17ClN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 42n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191952
PNG
(4-cyano-3-(2'-cyano-biphenyl-4-yl)-5-ethyl-1-methy...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1C#N
Show InChI InChI=1S/C22H17N3O2/c1-3-19-18(13-24)20(21(22(26)27)25(19)2)15-10-8-14(9-11-15)17-7-5-4-6-16(17)12-23/h4-11H,3H2,1-2H3,(H,26,27)
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n/an/an/an/a 56n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191951
PNG
(4-cyano-5-ethyl-3-(4'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)15-6-4-13(5-7-15)14-8-10-16(22)11-9-14/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 242n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191950
PNG
(4-cyano-5-ethyl-3-(3'-methoxy-biphenyl-4-yl)-1-met...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1cccc(OC)c1
Show InChI InChI=1S/C22H20N2O3/c1-4-19-18(13-23)20(21(22(25)26)24(19)2)15-10-8-14(9-11-15)16-6-5-7-17(12-16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 391n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191954
PNG
(3-(2'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1Cl
Show InChI InChI=1S/C21H17ClN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 55n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191947
PNG
(4-cyano-5-ethyl-1-methyl-3-(4'-methyl-biphenyl-4-y...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(C)cc1
Show InChI InChI=1S/C22H20N2O2/c1-4-19-18(13-23)20(21(22(25)26)24(19)3)17-11-9-16(10-12-17)15-7-5-14(2)6-8-15/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 1.14E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191954
PNG
(3-(2'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1Cl
Show InChI InChI=1S/C21H17ClN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 225n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191948
PNG
(4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-16(12-23)19(20(21(25)26)24(18)2)14-10-8-13(9-11-14)15-6-4-5-7-17(15)22/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 80n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191951
PNG
(4-cyano-5-ethyl-3-(4'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)15-6-4-13(5-7-15)14-8-10-16(22)11-9-14/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 2.95E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191956
PNG
(3-(4'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)15-6-4-13(5-7-15)14-8-10-16(22)11-9-14/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191964
PNG
(3-(3'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C21H17ClN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)14-9-7-13(8-10-14)15-5-4-6-16(22)11-15/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 186n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191966
PNG
(3-biphenyl-4-yl-4-cyano-1-methyl-1H-pyrrole-2-carb...)
Show SMILES Cn1cc(C#N)c(c1C(O)=O)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H14N2O2/c1-21-12-16(11-20)17(18(21)19(22)23)15-9-7-14(8-10-15)13-5-3-2-4-6-13/h2-10,12H,1H3,(H,22,23)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191949
PNG
(4-cyano-5-ethyl-3-(3'-fluoro-biphenyl-4-yl)-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1cccc(F)c1
Show InChI InChI=1S/C21H17FN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)14-9-7-13(8-10-14)15-5-4-6-16(22)11-15/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 223n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191955
PNG
(3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrol...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H18N2O2/c1-3-18-17(13-22)19(20(21(24)25)23(18)2)16-11-9-15(10-12-16)14-7-5-4-6-8-14/h4-12H,3H2,1-2H3,(H,24,25)
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n/an/an/an/a 213n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191950
PNG
(4-cyano-5-ethyl-3-(3'-methoxy-biphenyl-4-yl)-1-met...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1cccc(OC)c1
Show InChI InChI=1S/C22H20N2O3/c1-4-19-18(13-23)20(21(22(25)26)24(19)2)15-10-8-14(9-11-15)16-6-5-7-17(12-16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191960
PNG
(4-cyano-5-ethyl-3-(4'-methoxy-biphenyl-4-yl)-1-met...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(OC)cc1
Show InChI InChI=1S/C22H20N2O3/c1-4-19-18(13-23)20(21(22(25)26)24(19)2)16-7-5-14(6-8-16)15-9-11-17(27-3)12-10-15/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 423n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191960
PNG
(4-cyano-5-ethyl-3-(4'-methoxy-biphenyl-4-yl)-1-met...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(OC)cc1
Show InChI InChI=1S/C22H20N2O3/c1-4-19-18(13-23)20(21(22(25)26)24(19)2)16-7-5-14(6-8-16)15-9-11-17(27-3)12-10-15/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191956
PNG
(3-(4'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClN2O2/c1-3-18-17(12-23)19(20(21(25)26)24(18)2)15-6-4-13(5-7-15)14-8-10-16(22)11-9-14/h4-11H,3H2,1-2H3,(H,25,26)
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n/an/an/an/a 984n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191958
PNG
(4-cyano-5-ethyl-3-(2'-methoxy-biphenyl-4-yl)-1-met...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1OC
Show InChI InChI=1S/C22H20N2O3/c1-4-18-17(13-23)20(21(22(25)26)24(18)2)15-11-9-14(10-12-15)16-7-5-6-8-19(16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 673n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50191947
PNG
(4-cyano-5-ethyl-1-methyl-3-(4'-methyl-biphenyl-4-y...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccc(C)cc1
Show InChI InChI=1S/C22H20N2O2/c1-4-19-18(13-23)20(21(22(25)26)24(19)3)17-11-9-16(10-12-17)15-7-5-14(2)6-8-15/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR4 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191966
PNG
(3-biphenyl-4-yl-4-cyano-1-methyl-1H-pyrrole-2-carb...)
Show SMILES Cn1cc(C#N)c(c1C(O)=O)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H14N2O2/c1-21-12-16(11-20)17(18(21)19(22)23)15-9-7-14(8-10-15)13-5-3-2-4-6-13/h2-10,12H,1H3,(H,22,23)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191958
PNG
(4-cyano-5-ethyl-3-(2'-methoxy-biphenyl-4-yl)-1-met...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1OC
Show InChI InChI=1S/C22H20N2O3/c1-4-18-17(13-23)20(21(22(25)26)24(18)2)15-11-9-14(10-12-15)16-7-5-6-8-19(16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 280n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50191961
PNG
(4-cyano-5-ethyl-1-methyl-3-(2'-methylsulfanyl-biph...)
Show SMILES CCc1c(C#N)c(c(C(O)=O)n1C)-c1ccc(cc1)-c1ccccc1SC
Show InChI InChI=1S/C22H20N2O2S/c1-4-18-17(13-23)20(21(22(25)26)24(18)2)15-11-9-14(10-12-15)16-7-5-6-8-19(16)27-3/h5-12H,4H2,1-3H3,(H,25,26)
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n/an/an/an/a 57n/an/an/an/a



Eli Lilly and Co

Curated by ChEMBL


Assay Description
Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...


Bioorg Med Chem Lett 16: 5203-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.012
BindingDB Entry DOI: 10.7270/Q21G0KWF
More data for this
Ligand-Target Pair
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