BindingDB logo
myBDB logout

6 similar compounds to monomer 50193624

Wt: 429.4
BDBM50193698
Wt: 333.4
BDBM50193614
Wt: 387.4
BDBM50193625
Wt: 387.3
BDBM50193633
Wt: 415.4
BDBM50193648
Wt: 373.3
BDBM50444711

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50193698,50193614,50193625,50193633,50193648,50444711   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50193625
PNG
(2-propyl-N6-(3-(4-(trifluoromethyl)phenyl)propyl)q...)
Show SMILES CCCc1cc(N)c2cc(NCCCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C22H24F3N3/c1-2-4-18-14-20(26)19-13-17(10-11-21(19)28-18)27-12-3-5-15-6-8-16(9-7-15)22(23,24)25/h6-11,13-14,27H,2-5,12H2,1H3,(H2,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50193614
PNG
(CHEMBL215955 | N-(4-amino-2-propylquinolin-6-yl)-3...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)CCc3ccccc3)ccc2n1
Show InChI InChI=1S/C21H23N3O/c1-2-6-16-14-19(22)18-13-17(10-11-20(18)23-16)24-21(25)12-9-15-7-4-3-5-8-15/h3-5,7-8,10-11,13-14H,2,6,9,12H2,1H3,(H2,22,23)(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50193633
PNG
(CHEMBL386509 | N-(4-amino-2-propylquinolin-6-yl)-2...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)Cc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C21H20F3N3O/c1-2-3-15-12-18(25)17-11-16(8-9-19(17)26-15)27-20(28)10-13-4-6-14(7-5-13)21(22,23)24/h4-9,11-12H,2-3,10H2,1H3,(H2,25,26)(H,27,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)

More data for this
Ligand-Target Pair
Antrax lethal toxin


(Bacillus anthracis)
BDBM50444711
PNG
(CHEMBL3099007)
Show SMILES Cc1cc(N)c2cc(NC(=O)CCc3ccccc3C(F)(F)F)ccc2n1
Show InChI InChI=1S/C20H18F3N3O/c1-12-10-17(24)15-11-14(7-8-18(15)25-12)26-19(27)9-6-13-4-2-3-5-16(13)20(21,22)23/h2-5,7-8,10-11H,6,9H2,1H3,(H2,24,25)(H,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.80E+4n/an/an/an/an/an/a



Microbiotix, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Bacillus anthracis lethal factor assessed as MCA-KKVYPYPME[dnp]K amide cleavage after 30 mins by fluorescence plate reader analysis


Bioorg Med Chem 22: 419-34 (2013)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50193625
PNG
(2-propyl-N6-(3-(4-(trifluoromethyl)phenyl)propyl)q...)
Show SMILES CCCc1cc(N)c2cc(NCCCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C22H24F3N3/c1-2-4-18-14-20(26)19-13-17(10-11-21(19)28-18)27-12-3-5-15-6-8-16(9-7-15)22(23,24)25/h6-11,13-14,27H,2-5,12H2,1H3,(H2,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50193698
PNG
(CHEMBL267319 | N-(4-(dimethylamino)-2-propylquinol...)
Show SMILES CCCc1cc(N(C)C)c2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C24H26F3N3O/c1-4-5-18-15-22(30(2)3)20-14-19(11-12-21(20)28-18)29-23(31)13-8-16-6-9-17(10-7-16)24(25,26)27/h6-7,9-12,14-15H,4-5,8,13H2,1-3H3,(H,29,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)

More data for this
Ligand-Target Pair
Botulinum neurotoxin type A


(Clostridium botulinum)
BDBM50444711
PNG
(CHEMBL3099007)
Show SMILES Cc1cc(N)c2cc(NC(=O)CCc3ccccc3C(F)(F)F)ccc2n1
Show InChI InChI=1S/C20H18F3N3O/c1-12-10-17(24)15-11-14(7-8-18(15)25-12)26-19(27)9-6-13-4-2-3-5-16(13)20(21,22)23/h2-5,7-8,10-11H,6,9H2,1H3,(H2,24,25)(H,26,27)
PDB
MMDB

NCI pathway
Reactome pathway

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Microbiotix, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Clostridium bolulinum BoNT/A assessed as cleavage of MOCAc-Lys-Lys-Val-Tyr-Pro-Tyr-Pro-Met-Glu-Lys(Dnp)-NH2 after 40 mins by FRET assay


Bioorg Med Chem 22: 419-34 (2013)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50193648
PNG
(CHEMBL385361 | N-(4-amino-2-propylquinolin-6-yl)-N...)
Show SMILES CCCc1cc(N)c2cc(ccc2n1)N(C)C(=O)CCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N3O/c1-3-4-17-13-20(27)19-14-18(10-11-21(19)28-17)29(2)22(30)12-7-15-5-8-16(9-6-15)23(24,25)26/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3,(H2,27,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)

More data for this
Ligand-Target Pair