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3 similar compounds to monomer 50193604

Wt: 347.4
BDBM50193619
Wt: 345.4
BDBM50193626
Wt: 331.4
BDBM50241092

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50193619,50193626,50241092   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50193626
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-p-tolylacr...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(C)cc3)ccc2n1
Show InChI InChI=1S/C22H23N3O/c1-3-4-17-14-20(23)19-13-18(10-11-21(19)24-17)25-22(26)12-9-16-7-5-15(2)6-8-16/h5-14H,3-4H2,1-2H3,(H2,23,24)(H,25,26)/b12-9+
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 71n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50241092
PNG
(CHEMBL385639 | N-(4-amino-2-propylquinolin-6-yl)ci...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccccc3)ccc2n1
Show InChI InChI=1S/C21H21N3O/c1-2-6-16-14-19(22)18-13-17(10-11-20(18)23-16)24-21(25)12-9-15-7-4-3-5-8-15/h3-5,7-14H,2,6H2,1H3,(H2,22,23)(H,24,25)/b12-9+
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PC sid
UniChem

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Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50193626
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-p-tolylacr...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(C)cc3)ccc2n1
Show InChI InChI=1S/C22H23N3O/c1-3-4-17-14-20(23)19-13-18(10-11-21(19)24-17)25-22(26)12-9-16-7-5-15(2)6-8-16/h5-14H,3-4H2,1-2H3,(H2,23,24)(H,25,26)/b12-9+
Reactome pathway
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UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50193619
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-hydroxy...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(O)cc3)ccc2n1
Show InChI InChI=1S/C21H21N3O2/c1-2-3-15-13-19(22)18-12-16(7-10-20(18)23-15)24-21(26)11-6-14-4-8-17(25)9-5-14/h4-13,25H,2-3H2,1H3,(H2,22,23)(H,24,26)/b11-6+
Reactome pathway
KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)

More data for this
Ligand-Target Pair