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12 similar compounds to monomer 50192756

Compile data set for download or QSAR
Wt: 477.6
BDBM50201174
Wt: 504.6
BDBM50201175
Wt: 405.9
BDBM50201189
Wt: 385.5
BDBM50201193
Wt: 439.4
BDBM50201194
Wt: 389.4
BDBM50201199
Wt: 401.5
BDBM50201205
Wt: 464.4
BDBM50201180
Wt: 464.4
BDBM50201182
Wt: 385.5
BDBM50201188
Wt: 387.4
BDBM50201192
Wt: 439.5
BDBM50201213

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50201174,50201175,50201189,50201193,50201194,50201199,50201205,50201180,50201182,50201188,50201192,50201213   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rhodesain


(Trypanosoma brucei rhodesiense)
BDBM50201213
PNG
(CHEMBL3934979)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)\C=C\[N+]([O-])=O
Show InChI InChI=1S/C24H29N3O5/c1-18(2)15-21(13-14-27(30)31)25-23(28)22(16-19-9-5-3-6-10-19)26-24(29)32-17-20-11-7-4-8-12-20/h3-14,18,21-22H,15-17H2,1-2H3,(H,25,28)(H,26,29)/b14-13+/t21-,22+/m1/s1
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6.5n/an/an/an/an/an/an/an/a



Universitat Jaume I

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 15 to 30 mins by fluores...


ACS Med Chem Lett 7: 1073-1076 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00276
BindingDB Entry DOI: 10.7270/Q2M32XR1
More data for this
Ligand-Target Pair
Cruzipain


(Trypanosoma cruzi)
BDBM50201213
PNG
(CHEMBL3934979)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)\C=C\[N+]([O-])=O
Show InChI InChI=1S/C24H29N3O5/c1-18(2)15-21(13-14-27(30)31)25-23(28)22(16-19-9-5-3-6-10-19)26-24(29)32-17-20-11-7-4-8-12-20/h3-14,18,21-22H,15-17H2,1-2H3,(H,25,28)(H,26,29)/b14-13+/t21-,22+/m1/s1
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16n/an/an/an/an/an/an/an/a



Universitat Jaume I

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma cruzi cruzain


ACS Med Chem Lett 7: 1073-1076 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00276
BindingDB Entry DOI: 10.7270/Q2M32XR1
More data for this
Ligand-Target Pair
Cathepsin (L and K)


(Homo sapiens (Human))
BDBM50201213
PNG
(CHEMBL3934979)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)\C=C\[N+]([O-])=O
Show InChI InChI=1S/C24H29N3O5/c1-18(2)15-21(13-14-27(30)31)25-23(28)22(16-19-9-5-3-6-10-19)26-24(29)32-17-20-11-7-4-8-12-20/h3-14,18,21-22H,15-17H2,1-2H3,(H,25,28)(H,26,29)/b14-13+/t21-,22+/m1/s1
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30n/an/an/an/an/an/an/an/a



Universitat Jaume I

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin L


ACS Med Chem Lett 7: 1073-1076 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00276
BindingDB Entry DOI: 10.7270/Q2M32XR1
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens (Human))
BDBM50201213
PNG
(CHEMBL3934979)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)\C=C\[N+]([O-])=O
Show InChI InChI=1S/C24H29N3O5/c1-18(2)15-21(13-14-27(30)31)25-23(28)22(16-19-9-5-3-6-10-19)26-24(29)32-17-20-11-7-4-8-12-20/h3-14,18,21-22H,15-17H2,1-2H3,(H,25,28)(H,26,29)/b14-13+/t21-,22+/m1/s1
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68n/an/an/an/an/an/an/an/a



Universitat Jaume I

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin B


ACS Med Chem Lett 7: 1073-1076 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00276
BindingDB Entry DOI: 10.7270/Q2M32XR1
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens (Human))
BDBM50201192
PNG
(CHEMBL3932681)
Show SMILES Oc1cccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)c1
Show InChI InChI=1S/C19H25N5O2S/c25-15-7-4-5-13(9-15)10-24-11-14(22-23-24)6-2-1-3-8-17-18-16(12-27-17)20-19(26)21-18/h4-5,7,9,11,16-18,25H,1-3,6,8,10,12H2,(H2,20,21,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens (Human))
BDBM50201188
PNG
(CHEMBL3891635)
Show SMILES Cc1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C20H27N5OS/c1-14-7-9-15(10-8-14)11-25-12-16(23-24-25)5-3-2-4-6-18-19-17(13-27-18)21-20(26)22-19/h7-10,12,17-19H,2-6,11,13H2,1H3,(H2,21,22,26)/t17-,18-,19-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens (Human))
BDBM50201193
PNG
(CHEMBL3974372)
Show SMILES Cc1cccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)c1
Show InChI InChI=1S/C20H27N5OS/c1-14-6-5-7-15(10-14)11-25-12-16(23-24-25)8-3-2-4-9-18-19-17(13-27-18)21-20(26)22-19/h5-7,10,12,17-19H,2-4,8-9,11,13H2,1H3,(H2,21,22,26)/t17-,18-,19-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens (Human))
BDBM50201194
PNG
(CHEMBL3932600)
Show SMILES FC(F)(F)c1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C20H24F3N5OS/c21-20(22,23)14-8-6-13(7-9-14)10-28-11-15(26-27-28)4-2-1-3-5-17-18-16(12-30-17)24-19(29)25-18/h6-9,11,16-18H,1-5,10,12H2,(H2,24,25,29)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens (Human))
BDBM50201189
PNG
(CHEMBL3984675)
Show SMILES Clc1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C19H24ClN5OS/c20-14-8-6-13(7-9-14)10-25-11-15(23-24-25)4-2-1-3-5-17-18-16(12-27-17)21-19(26)22-18/h6-9,11,16-18H,1-5,10,12H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens (Human))
BDBM50201205
PNG
(CHEMBL3914706)
Show SMILES COc1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C20H27N5O2S/c1-27-16-9-7-14(8-10-16)11-25-12-15(23-24-25)5-3-2-4-6-18-19-17(13-28-18)21-20(26)22-19/h7-10,12,17-19H,2-6,11,13H2,1H3,(H2,21,22,26)/t17-,18-,19-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Biotin--protein ligase


(Homo sapiens (Human))
BDBM50201199
PNG
(CHEMBL3934430)
Show SMILES Fc1ccc(Cn2cc(CCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)cc1
Show InChI InChI=1S/C19H24FN5OS/c20-14-8-6-13(7-9-14)10-25-11-15(23-24-25)4-2-1-3-5-17-18-16(12-27-17)21-19(26)22-18/h6-9,11,16-18H,1-5,10,12H2,(H2,21,22,26)/t16-,17-,18-/m0/s1
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>1.60E+4n/an/an/an/an/an/an/an/a



University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of human biotin protein ligase assessed as reduction in 3H-biotin incorporation into pyruvate carboxylase biotin domain after 10 mins by l...


ACS Med Chem Lett 7: 1068-1072 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00248
BindingDB Entry DOI: 10.7270/Q2QV3PGF
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50201182
PNG
(CHEMBL3929080)
Show SMILES COc1cc(ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1cncs1)C(F)(F)F
Show InChI InChI=1S/C21H15F3N2O3S2/c1-29-19-10-14(21(22,23)24)5-7-18(19)17-4-2-3-13-9-15(6-8-16(13)17)31(27,28)26-20-11-25-12-30-20/h2-12,26H,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...


ACS Med Chem Lett 7: 1062-1067 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00243
BindingDB Entry DOI: 10.7270/Q2VM4F65
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50201180
PNG
(CHEMBL3910180)
Show SMILES COc1cc(ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1S/C21H15F3N2O3S2/c1-29-19-10-14(21(22,23)24)5-7-18(19)17-4-2-3-13-9-15(6-8-16(13)17)31(27,28)26-20-11-30-12-25-20/h2-12,26H,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...


ACS Med Chem Lett 7: 1062-1067 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00243
BindingDB Entry DOI: 10.7270/Q2VM4F65
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50201180
PNG
(CHEMBL3910180)
Show SMILES COc1cc(ccc1-c1cccc2cc(ccc12)S(=O)(=O)Nc1cscn1)C(F)(F)F
Show InChI InChI=1S/C21H15F3N2O3S2/c1-29-19-10-14(21(22,23)24)5-7-18(19)17-4-2-3-13-9-15(6-8-16(13)17)31(27,28)26-20-11-30-12-25-20/h2-12,26H,1H3
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n/an/a 2.10E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human Nav1.5 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min...


ACS Med Chem Lett 7: 1062-1067 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00243
BindingDB Entry DOI: 10.7270/Q2VM4F65
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM50201175
PNG
(CHEMBL3961508)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn3CCCC[C@H](N)C(=O)NCCCCNc4ncc2c3n4)CC1
Show InChI InChI=1S/C28H40N8O/c1-34-14-16-35(17-15-34)19-21-7-9-22(10-8-21)24-20-36-13-5-2-6-25(29)27(37)30-11-3-4-12-31-28-32-18-23(24)26(36)33-28/h7-10,18,20,25H,2-6,11-17,19,29H2,1H3,(H,30,37)(H,31,32,33)/t25-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Tyro3 (unknown origin) by microfluidic capillary electrophoresis assay


ACS Med Chem Lett 7: 1044-1049 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00221
BindingDB Entry DOI: 10.7270/Q208679K
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50201175
PNG
(CHEMBL3961508)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn3CCCC[C@H](N)C(=O)NCCCCNc4ncc2c3n4)CC1
Show InChI InChI=1S/C28H40N8O/c1-34-14-16-35(17-15-34)19-21-7-9-22(10-8-21)24-20-36-13-5-2-6-25(29)27(37)30-11-3-4-12-31-28-32-18-23(24)26(36)33-28/h7-10,18,20,25H,2-6,11-17,19,29H2,1H3,(H,30,37)(H,31,32,33)/t25-/m0/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of human MerTK kinase domain (1585 to 3000 residues) expressed in HEK293 cells co-expressing rat EGFR LBD assessed as inhibition of EGF-st...


ACS Med Chem Lett 7: 1044-1049 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00221
BindingDB Entry DOI: 10.7270/Q208679K
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50201174
PNG
(CHEMBL3969591)
Show SMILES OC1CCCCCCCNc2ncc3c(cn(CCCC1)c3n2)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C28H39N5O2/c34-24-8-4-2-1-3-6-14-29-28-30-20-25-26(21-33(27(25)31-28)15-7-5-9-24)22-10-12-23(13-11-22)32-16-18-35-19-17-32/h10-13,20-21,24,34H,1-9,14-19H2,(H,29,30,31)
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n/an/a 180n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Axl (unknown origin) by microfluidic capillary electrophoresis assay


ACS Med Chem Lett 7: 1044-1049 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00221
BindingDB Entry DOI: 10.7270/Q208679K
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50201174
PNG
(CHEMBL3969591)
Show SMILES OC1CCCCCCCNc2ncc3c(cn(CCCC1)c3n2)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C28H39N5O2/c34-24-8-4-2-1-3-6-14-29-28-30-20-25-26(21-33(27(25)31-28)15-7-5-9-24)22-10-12-23(13-11-22)32-16-18-35-19-17-32/h10-13,20-21,24,34H,1-9,14-19H2,(H,29,30,31)
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n/an/an/an/a 690n/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of human MerTK kinase domain (1585 to 3000 residues) expressed in HEK293 cells co-expressing rat EGFR LBD assessed as inhibition of EGF-st...


ACS Med Chem Lett 7: 1044-1049 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00221
BindingDB Entry DOI: 10.7270/Q208679K
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50201175
PNG
(CHEMBL3961508)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn3CCCC[C@H](N)C(=O)NCCCCNc4ncc2c3n4)CC1
Show InChI InChI=1S/C28H40N8O/c1-34-14-16-35(17-15-34)19-21-7-9-22(10-8-21)24-20-36-13-5-2-6-25(29)27(37)30-11-3-4-12-31-28-32-18-23(24)26(36)33-28/h7-10,18,20,25H,2-6,11-17,19,29H2,1H3,(H,30,37)(H,31,32,33)/t25-/m0/s1
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n/an/a 8.90n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of MerTK (unknown origin) by microfluidic capillary electrophoresis assay


ACS Med Chem Lett 7: 1044-1049 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00221
BindingDB Entry DOI: 10.7270/Q208679K
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50201174
PNG
(CHEMBL3969591)
Show SMILES OC1CCCCCCCNc2ncc3c(cn(CCCC1)c3n2)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C28H39N5O2/c34-24-8-4-2-1-3-6-14-29-28-30-20-25-26(21-33(27(25)31-28)15-7-5-9-24)22-10-12-23(13-11-22)32-16-18-35-19-17-32/h10-13,20-21,24,34H,1-9,14-19H2,(H,29,30,31)
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n/an/a 32n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of MerTK (unknown origin) by microfluidic capillary electrophoresis assay


ACS Med Chem Lett 7: 1044-1049 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00221
BindingDB Entry DOI: 10.7270/Q208679K
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50201175
PNG
(CHEMBL3961508)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn3CCCC[C@H](N)C(=O)NCCCCNc4ncc2c3n4)CC1
Show InChI InChI=1S/C28H40N8O/c1-34-14-16-35(17-15-34)19-21-7-9-22(10-8-21)24-20-36-13-5-2-6-25(29)27(37)30-11-3-4-12-31-28-32-18-23(24)26(36)33-28/h7-10,18,20,25H,2-6,11-17,19,29H2,1H3,(H,30,37)(H,31,32,33)/t25-/m0/s1
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n/an/a 150n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Axl (unknown origin) by microfluidic capillary electrophoresis assay


ACS Med Chem Lett 7: 1044-1049 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00221
BindingDB Entry DOI: 10.7270/Q208679K
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM50201174
PNG
(CHEMBL3969591)
Show SMILES OC1CCCCCCCNc2ncc3c(cn(CCCC1)c3n2)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C28H39N5O2/c34-24-8-4-2-1-3-6-14-29-28-30-20-25-26(21-33(27(25)31-28)15-7-5-9-24)22-10-12-23(13-11-22)32-16-18-35-19-17-32/h10-13,20-21,24,34H,1-9,14-19H2,(H,29,30,31)
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n/an/a 350n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Tyro3 (unknown origin) by microfluidic capillary electrophoresis assay


ACS Med Chem Lett 7: 1044-1049 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00221
BindingDB Entry DOI: 10.7270/Q208679K
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50201174
PNG
(CHEMBL3969591)
Show SMILES OC1CCCCCCCNc2ncc3c(cn(CCCC1)c3n2)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C28H39N5O2/c34-24-8-4-2-1-3-6-14-29-28-30-20-25-26(21-33(27(25)31-28)15-7-5-9-24)22-10-12-23(13-11-22)32-16-18-35-19-17-32/h10-13,20-21,24,34H,1-9,14-19H2,(H,29,30,31)
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n/an/a 68n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Flt3 (unknown origin) by microfluidic capillary electrophoresis assay


ACS Med Chem Lett 7: 1044-1049 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00221
BindingDB Entry DOI: 10.7270/Q208679K
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50201175
PNG
(CHEMBL3961508)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn3CCCC[C@H](N)C(=O)NCCCCNc4ncc2c3n4)CC1
Show InChI InChI=1S/C28H40N8O/c1-34-14-16-35(17-15-34)19-21-7-9-22(10-8-21)24-20-36-13-5-2-6-25(29)27(37)30-11-3-4-12-31-28-32-18-23(24)26(36)33-28/h7-10,18,20,25H,2-6,11-17,19,29H2,1H3,(H,30,37)(H,31,32,33)/t25-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Flt3 (unknown origin) by microfluidic capillary electrophoresis assay


ACS Med Chem Lett 7: 1044-1049 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00221
BindingDB Entry DOI: 10.7270/Q208679K
More data for this
Ligand-Target Pair