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5 similar compounds to monomer 50143890

Compile data set for download or QSAR
Wt: 351.3
BDBM50204899
Wt: 335.3
BDBM50241126
Wt: 349.4
BDBM50241127
Wt: 349.4
BDBM50241129
Wt: 447.3
BDBM50329502

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50204899,50241126,50241127,50241129,50329502   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50329502
PNG
(2-{[4-(4-Iodobenzyl)piperidin-1-yl]methyl}benzimid...)
Show SMILES Oc1ccc2nc(CN3CCC(Cc4ccc(I)cc4)CC3)[nH]c2c1
Show InChI InChI=1S/C20H22IN3O/c21-16-3-1-14(2-4-16)11-15-7-9-24(10-8-15)13-20-22-18-6-5-17(25)12-19(18)23-20/h1-6,12,15,25H,7-11,13H2,(H,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
7.28n/an/an/an/an/an/an/an/a



Hamamatsu University School of Medicine

Curated by ChEMBL


Assay Description
Displacement of [3H]ifenprodil from NR2B receptor in rat cortical synaptic membranes


Bioorg Med Chem 18: 7497-506 (2010)


Article DOI: 10.1016/j.bmc.2010.08.053
BindingDB Entry DOI: 10.7270/Q2MS3T06
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50241129
PNG
((5-hydroxy-1H-benzoimidazol-2-yl)-[4-(4-methyl-ben...)
Show SMILES Cc1ccc(CC2CCN(CC2)C(=O)c2nc3ccc(O)cc3[nH]2)cc1
Show InChI InChI=1S/C21H23N3O2/c1-14-2-4-15(5-3-14)12-16-8-10-24(11-9-16)21(26)20-22-18-7-6-17(25)13-19(18)23-20/h2-7,13,16,25H,8-12H2,1H3,(H,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 4.40n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane


Bioorg Med Chem Lett 16: 4638-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.002
BindingDB Entry DOI: 10.7270/Q2V69J7M
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50204899
PNG
((4-benzylpiperidine-1-yl)-[5(6)-hydroxy-1H-benzimi...)
Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H21N3O3/c24-17-11-15-16(12-18(17)25)22-19(21-15)20(26)23-8-6-14(7-9-23)10-13-4-2-1-3-5-13/h1-5,11-12,14,24-25H,6-10H2,(H,21,22)
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 2.20n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50204899
PNG
((4-benzylpiperidine-1-yl)-[5(6)-hydroxy-1H-benzimi...)
Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H21N3O3/c24-17-11-15-16(12-18(17)25)22-19(21-15)20(26)23-8-6-14(7-9-23)10-13-4-2-1-3-5-13/h1-5,11-12,14,24-25H,6-10H2,(H,21,22)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain


J Med Chem 50: 901-14 (2007)


Article DOI: 10.1021/jm060420k
BindingDB Entry DOI: 10.7270/Q2DV1JJ4
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50241126
PNG
((4-benzylpiperidin-1-yl)(5-hydroxy-1H-benzo[d]imid...)
Show SMILES Oc1ccc2nc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C20H21N3O2/c24-16-6-7-17-18(13-16)22-19(21-17)20(25)23-10-8-15(9-11-23)12-14-4-2-1-3-5-14/h1-7,13,15,24H,8-12H2,(H,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane


Bioorg Med Chem Lett 16: 4638-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.002
BindingDB Entry DOI: 10.7270/Q2V69J7M
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM50241127
PNG
((5-hydroxy-1H-benzoimidazol-2-yl)-[4-(3-methyl-ben...)
Show SMILES Cc1cccc(CC2CCN(CC2)C(=O)c2nc3ccc(O)cc3[nH]2)c1
Show InChI InChI=1S/C21H23N3O2/c1-14-3-2-4-16(11-14)12-15-7-9-24(10-8-15)21(26)20-22-18-6-5-17(25)13-19(18)23-20/h2-6,11,13,15,25H,7-10,12H2,1H3,(H,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Gedeon Richter Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane


Bioorg Med Chem Lett 16: 4638-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.002
BindingDB Entry DOI: 10.7270/Q2V69J7M
More data for this
Ligand-Target Pair