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5 similar compounds to monomer 50218018

Compile data set for download or QSAR
Wt: 375.4
BDBM50217996
Wt: 395.8
BDBM50218008
Wt: 411.4
BDBM50218011
Wt: 361.4
BDBM50218020
Wt: 395.8
BDBM50218031

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50217996,50218008,50218011,50218020,50218031   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycine transporter 2


(Homo sapiens (Human))
BDBM50218008
PNG
(CHEMBL399144 | {[2-(4''-chloro-[1,1';3',1'']terphe...)
Show SMILES CN(CCOc1ccc(cc1-c1ccc(Cl)cc1)-c1ccccc1)CC(O)=O
Show InChI InChI=1S/C23H22ClNO3/c1-25(16-23(26)27)13-14-28-22-12-9-19(17-5-3-2-4-6-17)15-21(22)18-7-10-20(24)11-8-18/h2-12,15H,13-14,16H2,1H3,(H,26,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [14C]glycine reuptake at human GlyT2 expressed in BE(2)-C cells


Bioorg Med Chem Lett 17: 5233-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.074
BindingDB Entry DOI: 10.7270/Q28915K8
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50218008
PNG
(CHEMBL399144 | {[2-(4''-chloro-[1,1';3',1'']terphe...)
Show SMILES CN(CCOc1ccc(cc1-c1ccc(Cl)cc1)-c1ccccc1)CC(O)=O
Show InChI InChI=1S/C23H22ClNO3/c1-25(16-23(26)27)13-14-28-22-12-9-19(17-5-3-2-4-6-17)15-21(22)18-7-10-20(24)11-8-18/h2-12,15H,13-14,16H2,1H3,(H,26,27)
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n/an/a 965n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [14C]glycine reuptake at human GlyT1 expressed in BE(2)-C cells


Bioorg Med Chem Lett 17: 5233-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.074
BindingDB Entry DOI: 10.7270/Q28915K8
More data for this
Ligand-Target Pair
Glycine transporter 2


(Homo sapiens (Human))
BDBM50217996
PNG
(CHEMBL248920 | {methyl-[2-(2''-methyl-[1,1';3',1''...)
Show SMILES CN(CCOc1ccc(cc1-c1ccccc1C)-c1ccccc1)CC(O)=O
Show InChI InChI=1S/C24H25NO3/c1-18-8-6-7-11-21(18)22-16-20(19-9-4-3-5-10-19)12-13-23(22)28-15-14-25(2)17-24(26)27/h3-13,16H,14-15,17H2,1-2H3,(H,26,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [14C]glycine reuptake at human GlyT2 expressed in BE(2)-C cells


Bioorg Med Chem Lett 17: 5233-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.074
BindingDB Entry DOI: 10.7270/Q28915K8
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50217996
PNG
(CHEMBL248920 | {methyl-[2-(2''-methyl-[1,1';3',1''...)
Show SMILES CN(CCOc1ccc(cc1-c1ccccc1C)-c1ccccc1)CC(O)=O
Show InChI InChI=1S/C24H25NO3/c1-18-8-6-7-11-21(18)22-16-20(19-9-4-3-5-10-19)12-13-23(22)28-15-14-25(2)17-24(26)27/h3-13,16H,14-15,17H2,1-2H3,(H,26,27)
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n/an/a 56n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [14C]glycine reuptake at human GlyT1 expressed in BE(2)-C cells


Bioorg Med Chem Lett 17: 5233-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.074
BindingDB Entry DOI: 10.7270/Q28915K8
More data for this
Ligand-Target Pair
Glycine transporter 2


(Homo sapiens (Human))
BDBM50218031
PNG
(CHEMBL250784 | {[2-(3''-chloro-[1,1';3',1'']terphe...)
Show SMILES CN(CCOc1ccc(cc1-c1cccc(Cl)c1)-c1ccccc1)CC(O)=O
Show InChI InChI=1S/C23H22ClNO3/c1-25(16-23(26)27)12-13-28-22-11-10-18(17-6-3-2-4-7-17)15-21(22)19-8-5-9-20(24)14-19/h2-11,14-15H,12-13,16H2,1H3,(H,26,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [14C]glycine reuptake at human GlyT2 expressed in BE(2)-C cells


Bioorg Med Chem Lett 17: 5233-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.074
BindingDB Entry DOI: 10.7270/Q28915K8
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50218020
PNG
(CHEMBL250580 | {methyl-[2-([1,1';3',1'']terphenyl-...)
Show SMILES CN(CCOc1ccc(cc1-c1ccccc1)-c1ccccc1)CC(O)=O
Show InChI InChI=1S/C23H23NO3/c1-24(17-23(25)26)14-15-27-22-13-12-20(18-8-4-2-5-9-18)16-21(22)19-10-6-3-7-11-19/h2-13,16H,14-15,17H2,1H3,(H,25,26)
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n/an/a 229n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [14C]glycine reuptake at human GlyT1 expressed in BE(2)-C cells


Bioorg Med Chem Lett 17: 5233-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.074
BindingDB Entry DOI: 10.7270/Q28915K8
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50218011
PNG
(CHEMBL250356 | {methyl-[2-(3-naphthalen-1-yl-biphe...)
Show SMILES CN(CCOc1ccc(cc1-c1cccc2ccccc12)-c1ccccc1)CC(O)=O
Show InChI InChI=1S/C27H25NO3/c1-28(19-27(29)30)16-17-31-26-15-14-22(20-8-3-2-4-9-20)18-25(26)24-13-7-11-21-10-5-6-12-23(21)24/h2-15,18H,16-17,19H2,1H3,(H,29,30)
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n/an/a 496n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [14C]glycine reuptake at human GlyT1 expressed in BE(2)-C cells


Bioorg Med Chem Lett 17: 5233-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.074
BindingDB Entry DOI: 10.7270/Q28915K8
More data for this
Ligand-Target Pair
Glycine transporter 2


(Homo sapiens (Human))
BDBM50218011
PNG
(CHEMBL250356 | {methyl-[2-(3-naphthalen-1-yl-biphe...)
Show SMILES CN(CCOc1ccc(cc1-c1cccc2ccccc12)-c1ccccc1)CC(O)=O
Show InChI InChI=1S/C27H25NO3/c1-28(19-27(29)30)16-17-31-26-15-14-22(20-8-3-2-4-9-20)18-25(26)24-13-7-11-21-10-5-6-12-23(21)24/h2-15,18H,16-17,19H2,1H3,(H,29,30)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [14C]glycine reuptake at human GlyT2 expressed in BE(2)-C cells


Bioorg Med Chem Lett 17: 5233-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.074
BindingDB Entry DOI: 10.7270/Q28915K8
More data for this
Ligand-Target Pair
Glycine transporter 2


(Homo sapiens (Human))
BDBM50218020
PNG
(CHEMBL250580 | {methyl-[2-([1,1';3',1'']terphenyl-...)
Show SMILES CN(CCOc1ccc(cc1-c1ccccc1)-c1ccccc1)CC(O)=O
Show InChI InChI=1S/C23H23NO3/c1-24(17-23(25)26)14-15-27-22-13-12-20(18-8-4-2-5-9-18)16-21(22)19-10-6-3-7-11-19/h2-13,16H,14-15,17H2,1H3,(H,25,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [14C]glycine reuptake at human GlyT2 expressed in BE(2)-C cells


Bioorg Med Chem Lett 17: 5233-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.074
BindingDB Entry DOI: 10.7270/Q28915K8
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM50218031
PNG
(CHEMBL250784 | {[2-(3''-chloro-[1,1';3',1'']terphe...)
Show SMILES CN(CCOc1ccc(cc1-c1cccc(Cl)c1)-c1ccccc1)CC(O)=O
Show InChI InChI=1S/C23H22ClNO3/c1-25(16-23(26)27)12-13-28-22-11-10-18(17-6-3-2-4-7-17)15-21(22)19-8-5-9-20(24)14-19/h2-11,14-15H,12-13,16H2,1H3,(H,26,27)
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n/an/a 674n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of [14C]glycine reuptake at human GlyT1 expressed in BE(2)-C cells


Bioorg Med Chem Lett 17: 5233-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.074
BindingDB Entry DOI: 10.7270/Q28915K8
More data for this
Ligand-Target Pair