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45 similar compounds to monomer 50219715

Wt: 441.4
BDBM50219665
Wt: 473.4
BDBM50219667
Wt: 473.4
BDBM50219668
Wt: 516.5
BDBM50219675
Wt: 458.4
BDBM50219677
Wt: 391.4
BDBM50219678
Wt: 477.4
BDBM50219679
Wt: 459.4
BDBM50219680
Wt: 459.4
BDBM50219685
Wt: 447.5
BDBM50219686
Wt: 401.4
BDBM50219687
Wt: 459.4
BDBM50219688
Wt: 419.4
BDBM50219689
Wt: 518.4
BDBM50219691
Wt: 459.4
BDBM50219703
Displayed 1 to 15 (of 45 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50219665,50219667,50219668,50219675,50219677,50219678,50219679,50219680,50219685,50219686,50219687,50219688,50219689,50219691,50219703   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219667
PNG
(CHEMBL399356 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Cc1sc(NC(=O)c2ccc(Nc3ccncn3)cc2)nc1-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H15F4N5OS/c1-12-19(15-3-2-4-16(18(15)23)22(24,25)26)30-21(33-12)31-20(32)13-5-7-14(8-6-13)29-17-9-10-27-11-28-17/h2-11H,1H3,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 540n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219665
PNG
(4-(pyrimidin-4-ylamino)-N-(4-(4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H14F3N5OS/c22-21(23,24)15-5-1-13(2-6-15)17-11-31-20(28-17)29-19(30)14-3-7-16(8-4-14)27-18-9-10-25-12-26-18/h1-12H,(H,25,26,27)(H,28,29,30)
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n/an/an/an/a 490n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219678
PNG
(CHEMBL248035 | N-(4-(2-fluorophenyl)thiazol-2-yl)-...)
Show SMILES Fc1ccccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H14FN5OS/c21-16-4-2-1-3-15(16)17-11-28-20(25-17)26-19(27)13-5-7-14(8-6-13)24-18-9-10-22-12-23-18/h1-12H,(H,22,23,24)(H,25,26,27)
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n/an/an/an/a 6.85E+3n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219677
PNG
(CHEMBL398466 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccccn3)cc2)n1
Show InChI InChI=1S/C22H14F4N4OS/c23-19-15(4-3-5-16(19)22(24,25)26)17-12-32-21(29-17)30-20(31)13-7-9-14(10-8-13)28-18-6-1-2-11-27-18/h1-12H,(H,27,28)(H,29,30,31)
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n/an/an/an/a 2.20E+3n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219679
PNG
(CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...)
Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 33n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219685
PNG
(CHEMBL247016 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccnnc3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-18-15(2-1-3-16(18)21(23,24)25)17-11-32-20(29-17)30-19(31)12-4-6-13(7-5-12)28-14-8-9-26-27-10-14/h1-11H,(H,26,28)(H,29,30,31)
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n/an/an/an/a 120n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219665
PNG
(4-(pyrimidin-4-ylamino)-N-(4-(4-(trifluoromethyl)p...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H14F3N5OS/c22-21(23,24)15-5-1-13(2-6-15)17-11-31-20(28-17)29-19(30)14-3-7-16(8-4-14)27-18-9-10-25-12-26-18/h1-12H,(H,25,26,27)(H,28,29,30)
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n/an/an/an/a 492n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219680
PNG
(CHEMBL247643 | N-(4-(3-fluoro-4-(trifluoromethyl)p...)
Show SMILES Fc1cc(ccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-16-9-13(3-6-15(16)21(23,24)25)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 288n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219691
PNG
(CHEMBL248041 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES OCCNc1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1
Show InChI InChI=1S/C23H18F4N6O2S/c24-20-15(2-1-3-16(20)23(25,26)27)17-11-36-22(32-17)33-21(35)13-4-6-14(7-5-13)31-19-10-18(28-8-9-34)29-12-30-19/h1-7,10-12,34H,8-9H2,(H,32,33,35)(H2,28,29,30,31)
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n/an/an/an/a 65n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219689
PNG
(CHEMBL395701 | N-(4-(3-ethyl-2-fluorophenyl)thiazo...)
Show SMILES CCc1cccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c1F
Show InChI InChI=1S/C22H18FN5OS/c1-2-14-4-3-5-17(20(14)23)18-12-30-22(27-18)28-21(29)15-6-8-16(9-7-15)26-19-10-11-24-13-25-19/h3-13H,2H2,1H3,(H,24,25,26)(H,27,28,29)
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n/an/an/an/a 143n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219686
PNG
(CHEMBL247040 | N-(4-(3-butyl-2-fluorophenyl)thiazo...)
Show SMILES CCCCc1cccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c1F
Show InChI InChI=1S/C24H22FN5OS/c1-2-3-5-16-6-4-7-19(22(16)25)20-14-32-24(29-20)30-23(31)17-8-10-18(11-9-17)28-21-12-13-26-15-27-21/h4,6-15H,2-3,5H2,1H3,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 53n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219688
PNG
(CHEMBL400741 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ncccn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-17-14(3-1-4-15(17)21(23,24)25)16-11-32-20(29-16)30-18(31)12-5-7-13(8-6-12)28-19-26-9-2-10-27-19/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 7.70E+3n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219675
PNG
(4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(4-(4-f...)
Show SMILES CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(c(C)s2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C24H20F4N6OS/c1-13-21(15-6-9-18(25)17(10-15)24(26,27)28)32-23(36-13)33-22(35)14-4-7-16(8-5-14)31-19-11-20(34(2)3)30-12-29-19/h4-12H,1-3H3,(H,29,30,31)(H,32,33,35)
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n/an/an/an/a 45n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219687
PNG
(CHEMBL248004 | N-(4-(3,4-dimethylphenyl)thiazol-2-...)
Show SMILES Cc1ccc(cc1C)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C22H19N5OS/c1-14-3-4-17(11-15(14)2)19-12-29-22(26-19)27-21(28)16-5-7-18(8-6-16)25-20-9-10-23-13-24-20/h3-13H,1-2H3,(H,23,24,25)(H,26,27,28)
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n/an/an/an/a 784n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219703
PNG
(CHEMBL248213 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3cnccn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-18-14(2-1-3-15(18)21(23,24)25)16-11-32-20(29-16)30-19(31)12-4-6-13(7-5-12)28-17-10-26-8-9-27-17/h1-11H,(H,27,28)(H,29,30,31)
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n/an/an/an/a 7.90E+3n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219678
PNG
(CHEMBL248035 | N-(4-(2-fluorophenyl)thiazol-2-yl)-...)
Show SMILES Fc1ccccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H14FN5OS/c21-16-4-2-1-3-15(16)17-11-28-20(25-17)26-19(27)13-5-7-14(8-6-13)24-18-9-10-22-12-23-18/h1-12H,(H,22,23,24)(H,25,26,27)
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n/an/an/an/a 6.80E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219680
PNG
(CHEMBL247643 | N-(4-(3-fluoro-4-(trifluoromethyl)p...)
Show SMILES Fc1cc(ccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-16-9-13(3-6-15(16)21(23,24)25)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 290n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219679
PNG
(CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...)
Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 33n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219668
PNG
(CHEMBL248215 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES CN(c1ccc(cc1)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F)c1ccncn1
Show InChI InChI=1S/C22H15F4N5OS/c1-31(18-9-10-27-12-28-18)14-7-5-13(6-8-14)20(32)30-21-29-17(11-33-21)15-3-2-4-16(19(15)23)22(24,25)26/h2-12H,1H3,(H,29,30,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair