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18 similar compounds to monomer 50219643

Wt: 473.4
BDBM50219667
Wt: 473.4
BDBM50219668
Wt: 477.4
BDBM50219679
Wt: 518.4
BDBM50219691
Wt: 459.4
BDBM50219707
Wt: 459.4
BDBM50219711
Wt: 473.4
BDBM50219714
Wt: 473.4
BDBM50219715
Wt: 459.4
BDBM50219607
Wt: 502.4
BDBM50219626
Wt: 487.4
BDBM50219628
Wt: 473.4
BDBM50219629
Wt: 514.4
BDBM50219633
Wt: 459.4
BDBM50219638
Wt: 477.4
BDBM50219646
Displayed 1 to 15 (of 18 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50219667,50219668,50219679,50219691,50219707,50219711,50219714,50219715,50219607,50219626,50219628,50219629,50219633,50219638,50219646   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219667
PNG
(CHEMBL399356 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Cc1sc(NC(=O)c2ccc(Nc3ccncn3)cc2)nc1-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H15F4N5OS/c1-12-19(15-3-2-4-16(18(15)23)22(24,25)26)30-21(33-12)31-20(32)13-5-7-14(8-6-13)29-17-9-10-27-11-28-17/h2-11H,1H3,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 540n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219607
PNG
(CHEMBL428226 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-18-14(2-1-3-15(18)21(23,24)25)16-10-32-20(29-16)30-19(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 60n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219679
PNG
(CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...)
Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 33n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219646
PNG
(CHEMBL247644 | N-(4-(2,3-difluoro-4-(trifluorometh...)
Show SMILES Fc1c(F)c(ccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1)C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-17-13(5-6-14(18(17)23)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 87n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219691
PNG
(CHEMBL248041 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES OCCNc1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1
Show InChI InChI=1S/C23H18F4N6O2S/c24-20-15(2-1-3-16(20)23(25,26)27)17-11-36-22(32-17)33-21(35)13-4-6-14(7-5-13)31-19-10-18(28-8-9-34)29-12-30-19/h1-7,10-12,34H,8-9H2,(H,32,33,35)(H2,28,29,30,31)
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n/an/an/an/a 65n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219638
PNG
(CHEMBL247822 | N-(4-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-16-6-3-13(9-15(16)21(23,24)25)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 104n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219626
PNG
(4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(4-(2-f...)
Show SMILES CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1
Show InChI InChI=1S/C23H18F4N6OS/c1-33(2)19-10-18(28-12-29-19)30-14-8-6-13(7-9-14)21(34)32-22-31-17(11-35-22)15-4-3-5-16(20(15)24)23(25,26)27/h3-12H,1-2H3,(H,28,29,30)(H,31,32,34)
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n/an/an/an/a 54n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219714
PNG
(CHEMBL245792 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES CN(C(=O)c1ccc(Nc2ccncn2)cc1)c1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H15F4N5OS/c1-31(20(32)13-5-7-14(8-6-13)29-18-9-10-27-12-28-18)21-30-17(11-33-21)15-3-2-4-16(19(15)23)22(24,25)26/h2-12H,1H3,(H,27,28,29)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219711
PNG
(CHEMBL248189 | N-(4-(2-fluoro-5-(trifluoromethyl)p...)
Show SMILES Fc1ccc(cc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1)C(F)(F)F
Show InChI InChI=1S/C21H13F4N5OS/c22-16-6-3-13(21(23,24)25)9-15(16)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 5.19E+3n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219607
PNG
(CHEMBL428226 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-18-14(2-1-3-15(18)21(23,24)25)16-10-32-20(29-16)30-19(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 60n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219715
PNG
(CHEMBL245794 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Cc1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1
Show InChI InChI=1S/C22H15F4N5OS/c1-12-9-18(28-11-27-12)29-14-7-5-13(6-8-14)20(32)31-21-30-17(10-33-21)15-3-2-4-16(19(15)23)22(24,25)26/h2-11H,1H3,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 43n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219707
PNG
(CHEMBL428227 | N-(4-(2-fluoro-4-(trifluoromethyl)p...)
Show SMILES Fc1cc(ccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1)C(F)(F)F
Show InChI InChI=1S/C21H13F4N5OS/c22-16-9-13(21(23,24)25)3-6-15(16)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 259n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219629
PNG
(CHEMBL245793 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Cc1nccc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)n1
Show InChI InChI=1S/C22H15F4N5OS/c1-12-27-10-9-18(28-12)29-14-7-5-13(6-8-14)20(32)31-21-30-17(11-33-21)15-3-2-4-16(19(15)23)22(24,25)26/h2-11H,1H3,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219628
PNG
(4-(2,6-dimethylpyrimidin-4-ylamino)-N-(4-(2-fluoro...)
Show SMILES Cc1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)nc(C)n1
Show InChI InChI=1S/C23H17F4N5OS/c1-12-10-19(29-13(2)28-12)30-15-8-6-14(7-9-15)21(33)32-22-31-18(11-34-22)16-4-3-5-17(20(16)24)23(25,26)27/h3-11H,1-2H3,(H,28,29,30)(H,31,32,33)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219633
PNG
(4-(6-(azetidin-1-yl)pyrimidin-4-ylamino)-N-(4-(2-f...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3cc(ncn3)N3CCC3)cc2)n1
Show InChI InChI=1S/C24H18F4N6OS/c25-21-16(3-1-4-17(21)24(26,27)28)18-12-36-23(32-18)33-22(35)14-5-7-15(8-6-14)31-19-11-20(30-13-29-19)34-9-2-10-34/h1,3-8,11-13H,2,9-10H2,(H,29,30,31)(H,32,33,35)
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n/an/an/an/a 23n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219638
PNG
(CHEMBL247822 | N-(4-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-16-6-3-13(9-15(16)21(23,24)25)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 100n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219646
PNG
(CHEMBL247644 | N-(4-(2,3-difluoro-4-(trifluorometh...)
Show SMILES Fc1c(F)c(ccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1)C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-17-13(5-6-14(18(17)23)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 87n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219679
PNG
(CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...)
Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 33n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219638
PNG
(CHEMBL247822 | N-(4-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-16-6-3-13(9-15(16)21(23,24)25)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 100n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219707
PNG
(CHEMBL428227 | N-(4-(2-fluoro-4-(trifluoromethyl)p...)
Show SMILES Fc1cc(ccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1)C(F)(F)F
Show InChI InChI=1S/C21H13F4N5OS/c22-16-9-13(21(23,24)25)3-6-15(16)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 260n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219668
PNG
(CHEMBL248215 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES CN(c1ccc(cc1)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F)c1ccncn1
Show InChI InChI=1S/C22H15F4N5OS/c1-31(18-9-10-27-12-28-18)14-7-5-13(6-8-14)20(32)30-21-29-17(11-33-21)15-3-2-4-16(19(15)23)22(24,25)26/h2-12H,1H3,(H,29,30,32)
Reactome pathway
KEGG

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PC cid
PC sid
UniChem

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AffyNet 
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair