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9 similar compounds to monomer 50219644

Wt: 473.4
BDBM50219668
Wt: 477.4
BDBM50219679
Wt: 459.4
BDBM50219711
Wt: 459.4
BDBM50219607
Wt: 502.4
BDBM50219626
Wt: 514.4
BDBM50219633
Wt: 459.4
BDBM50219638
Wt: 532.5
BDBM50219654
Wt: 502.4
BDBM50219662

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50219668,50219679,50219711,50219607,50219626,50219633,50219638,50219654,50219662   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219668
PNG
(CHEMBL248215 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES CN(c1ccc(cc1)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F)c1ccncn1
Show InChI InChI=1S/C22H15F4N5OS/c1-31(18-9-10-27-12-28-18)14-7-5-13(6-8-14)20(32)30-21-29-17(11-33-21)15-3-2-4-16(19(15)23)22(24,25)26/h2-12H,1H3,(H,29,30,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219679
PNG
(CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...)
Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 33n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219654
PNG
(CHEMBL440231 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES CN(CCO)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1
Show InChI InChI=1S/C24H20F4N6O2S/c1-34(9-10-35)20-11-19(29-13-30-20)31-15-7-5-14(6-8-15)22(36)33-23-32-18(12-37-23)16-3-2-4-17(21(16)25)24(26,27)28/h2-8,11-13,35H,9-10H2,1H3,(H,29,30,31)(H,32,33,36)
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n/an/an/an/a 22n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219662
PNG
(4-(6-(ethylamino)pyrimidin-4-ylamino)-N-(4-(2-fluo...)
Show SMILES CCNc1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1
Show InChI InChI=1S/C23H18F4N6OS/c1-2-28-18-10-19(30-12-29-18)31-14-8-6-13(7-9-14)21(34)33-22-32-17(11-35-22)15-4-3-5-16(20(15)24)23(25,26)27/h3-12H,2H2,1H3,(H,32,33,34)(H2,28,29,30,31)
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n/an/an/an/a 130n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219638
PNG
(CHEMBL247822 | N-(4-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-16-6-3-13(9-15(16)21(23,24)25)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 104n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219626
PNG
(4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(4-(2-f...)
Show SMILES CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1
Show InChI InChI=1S/C23H18F4N6OS/c1-33(2)19-10-18(28-12-29-19)30-14-8-6-13(7-9-14)21(34)32-22-31-17(11-35-22)15-4-3-5-16(20(15)24)23(25,26)27/h3-12H,1-2H3,(H,28,29,30)(H,31,32,34)
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n/an/an/an/a 54n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219607
PNG
(CHEMBL428226 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-18-14(2-1-3-15(18)21(23,24)25)16-10-32-20(29-16)30-19(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 60n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219607
PNG
(CHEMBL428226 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-18-14(2-1-3-15(18)21(23,24)25)16-10-32-20(29-16)30-19(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 60n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219633
PNG
(4-(6-(azetidin-1-yl)pyrimidin-4-ylamino)-N-(4-(2-f...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3cc(ncn3)N3CCC3)cc2)n1
Show InChI InChI=1S/C24H18F4N6OS/c25-21-16(3-1-4-17(21)24(26,27)28)18-12-36-23(32-18)33-22(35)14-5-7-15(8-6-14)31-19-11-20(30-13-29-19)34-9-2-10-34/h1,3-8,11-13H,2,9-10H2,(H,29,30,31)(H,32,33,35)
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n/an/an/an/a 23n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219638
PNG
(CHEMBL247822 | N-(4-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-16-6-3-13(9-15(16)21(23,24)25)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 100n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219679
PNG
(CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...)
Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 33n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219638
PNG
(CHEMBL247822 | N-(4-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5OS/c22-16-6-3-13(9-15(16)21(23,24)25)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 100n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219711
PNG
(CHEMBL248189 | N-(4-(2-fluoro-5-(trifluoromethyl)p...)
Show SMILES Fc1ccc(cc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1)C(F)(F)F
Show InChI InChI=1S/C21H13F4N5OS/c22-16-6-3-13(21(23,24)25)9-15(16)17-10-32-20(29-17)30-19(31)12-1-4-14(5-2-12)28-18-7-8-26-11-27-18/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 5.19E+3n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair