BindingDB logo
myBDB logout

12 similar compounds to monomer 50219619

Wt: 460.4
BDBM50219669
Wt: 531.4
BDBM50219670
Wt: 410.4
BDBM50219673
Wt: 503.4
BDBM50219698
Wt: 460.4
BDBM50219699
Wt: 547.5
BDBM50219705
Wt: 533.5
BDBM50219609
Wt: 564.5
BDBM50219614
Wt: 591.5
BDBM50219617
Wt: 515.4
BDBM50219634
Wt: 410.4
BDBM50219641
Wt: 460.4
BDBM50219661

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50219669,50219670,50219673,50219698,50219699,50219705,50219609,50219614,50219617,50219634,50219641,50219661   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219670
PNG
(CHEMBL249471 | N-(3-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES OC1CN(C1)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C23H17F4N7O2S/c24-17-6-3-13(7-16(17)23(25,26)27)20-31-22(37-33-20)32-21(36)12-1-4-14(5-2-12)30-18-8-19(29-11-28-18)34-9-15(35)10-34/h1-8,11,15,35H,9-10H2,(H,28,29,30)(H,31,32,33,36)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 13n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219669
PNG
(CHEMBL248054 | N-(3-(3-fluoro-4-(trifluoromethyl)p...)
Show SMILES Fc1cc(ccc1C(F)(F)F)-c1nsc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H12F4N6OS/c21-15-9-12(3-6-14(15)20(22,23)24)17-28-19(32-30-17)29-18(31)11-1-4-13(5-2-11)27-16-7-8-25-10-26-16/h1-10H,(H,25,26,27)(H,28,29,30,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219673
PNG
(CHEMBL248046 | N-(3-(2,4-difluorophenyl)-1,2,4-thi...)
Show SMILES Fc1ccc(-c2nsc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1
Show InChI InChI=1S/C19H12F2N6OS/c20-12-3-6-14(15(21)9-12)17-25-19(29-27-17)26-18(28)11-1-4-13(5-2-11)24-16-7-8-22-10-23-16/h1-10H,(H,22,23,24)(H,25,26,27,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.30E+3n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219617
PNG
(4-(6-(bis(3-hydroxypropyl)amino)pyrimidin-4-ylamin...)
Show SMILES OCCCN(CCCO)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C26H25F4N7O3S/c27-20-8-5-17(13-19(20)26(28,29)30)23-34-25(41-36-23)35-24(40)16-3-6-18(7-4-16)33-21-14-22(32-15-31-21)37(9-1-11-38)10-2-12-39/h3-8,13-15,38-39H,1-2,9-12H2,(H,31,32,33)(H,34,35,36,40)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 71n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219661
PNG
(CHEMBL398287 | N-(3-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1nsc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H12F4N6OS/c21-16-13(2-1-3-14(16)20(22,23)24)17-28-19(32-30-17)29-18(31)11-4-6-12(7-5-11)27-15-8-9-25-10-26-15/h1-10H,(H,25,26,27)(H,28,29,30,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.50E+3n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219641
PNG
(CHEMBL248047 | N-(3-(3,4-difluorophenyl)-1,2,4-thi...)
Show SMILES Fc1ccc(cc1F)-c1nsc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C19H12F2N6OS/c20-14-6-3-12(9-15(14)21)17-25-19(29-27-17)26-18(28)11-1-4-13(5-2-11)24-16-7-8-22-10-23-16/h1-10H,(H,22,23,24)(H,25,26,27,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 720n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219698
PNG
(4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(3-(4-f...)
Show SMILES CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C22H17F4N7OS/c1-33(2)18-10-17(27-11-28-18)29-14-6-3-12(4-7-14)20(34)31-21-30-19(32-35-21)13-5-8-16(23)15(9-13)22(24,25)26/h3-11H,1-2H3,(H,27,28,29)(H,30,31,32,34)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 43n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219705
PNG
(CHEMBL246428 | N-(3-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES COCCN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C24H21F4N7O2S/c1-35(9-10-37-2)20-12-19(29-13-30-20)31-16-6-3-14(4-7-16)22(36)33-23-32-21(34-38-23)15-5-8-18(25)17(11-15)24(26,27)28/h3-8,11-13H,9-10H2,1-2H3,(H,29,30,31)(H,32,33,34,36)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 130n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219609
PNG
(CHEMBL248434 | N-(3-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES CN(CCO)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C23H19F4N7O2S/c1-34(8-9-35)19-11-18(28-12-29-19)30-15-5-2-13(3-6-15)21(36)32-22-31-20(33-37-22)14-4-7-17(24)16(10-14)23(25,26)27/h2-7,10-12,35H,8-9H2,1H3,(H,28,29,30)(H,31,32,33,36)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 220n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219614
PNG
(CHEMBL249672 | N-(3-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES CN(C(CO)NO)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C23H20F4N8O3S/c1-35(19(10-36)33-38)18-9-17(28-11-29-18)30-14-5-2-12(3-6-14)21(37)32-22-31-20(34-39-22)13-4-7-16(24)15(8-13)23(25,26)27/h2-9,11,19,33,36,38H,10H2,1H3,(H,28,29,30)(H,31,32,34,37)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 29n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219634
PNG
(4-(6-(azetidin-1-yl)pyrimidin-4-ylamino)-N-(3-(4-f...)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1nsc(NC(=O)c2ccc(Nc3cc(ncn3)N3CCC3)cc2)n1
Show InChI InChI=1S/C23H17F4N7OS/c24-17-7-4-14(10-16(17)23(25,26)27)20-31-22(36-33-20)32-21(35)13-2-5-15(6-3-13)30-18-11-19(29-12-28-18)34-8-1-9-34/h2-7,10-12H,1,8-9H2,(H,28,29,30)(H,31,32,33,35)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 81n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219699
PNG
(CHEMBL248053 | N-(3-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES Fc1ccc(cc1C(F)(F)F)-c1nsc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H12F4N6OS/c21-15-6-3-12(9-14(15)20(22,23)24)17-28-19(32-30-17)29-18(31)11-1-4-13(5-2-11)27-16-7-8-25-10-26-16/h1-10H,(H,25,26,27)(H,28,29,30,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 410n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair