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1 similar compounds to monomer 50219621

Wt: 469.4
BDBM50219671

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50219671   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50219671
PNG
(4-(pyrimidin-4-ylamino)-N-(6-(trifluoromethyl)-4H-...)
Show SMILES FC(F)(F)c1cccc2-c3nc(NC(=O)c4ccc(Nc5ccncn5)cc4)sc3COc12
Show InChI InChI=1S/C22H14F3N5O2S/c23-22(24,25)15-3-1-2-14-18-16(10-32-19(14)15)33-21(29-18)30-20(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-9,11H,10H2,(H,26,27,28)(H,29,30,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 140n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219671
PNG
(4-(pyrimidin-4-ylamino)-N-(6-(trifluoromethyl)-4H-...)
Show SMILES FC(F)(F)c1cccc2-c3nc(NC(=O)c4ccc(Nc5ccncn5)cc4)sc3COc12
Show InChI InChI=1S/C22H14F3N5O2S/c23-22(24,25)15-3-1-2-14-18-16(10-32-19(14)15)33-21(29-18)30-20(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-9,11H,10H2,(H,26,27,28)(H,29,30,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 140n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair