BindingDB logo
myBDB logout

18 similar compounds to monomer 50222905

Compile data set for download or QSAR
Wt: 316.1
BDBM50258439
Purchase
Wt: 363.4
BDBM50222890
Wt: 423.4
BDBM50222893
Wt: 387.5
BDBM50222894
Wt: 364.4
BDBM50222895
Wt: 363.4
BDBM50222898
Wt: 387.5
BDBM50222900
Wt: 284.3
BDBM50222903
Wt: 269.3
BDBM50222904
Wt: 323.3
BDBM50222906
Wt: 242.2
BDBM50222910
Wt: 298.3
BDBM50222911
Wt: 405.4
BDBM50222891
Wt: 389.4
BDBM50222896
Wt: 269.3
BDBM50222909
Displayed 1 to 15 (of 18 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 49 hits for monomerid = 50258439,50222890,50222893,50222894,50222895,50222898,50222900,50222903,50222904,50222906,50222910,50222911,50222891,50222896,50222909   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50222900
PNG
(CHEMBL267062)
Show SMILES O=C1N(CCN2CCC(CC2)c2c[nH]c3ccccc23)CCCc2ccccc12
Show InChI InChI=1S/C25H29N3O/c29-25-21-8-2-1-6-19(21)7-5-13-28(25)17-16-27-14-11-20(12-15-27)23-18-26-24-10-4-3-9-22(23)24/h1-4,6,8-10,18,20,26H,5,7,11-17H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.407n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50222900
PNG
(CHEMBL267062)
Show SMILES O=C1N(CCN2CCC(CC2)c2c[nH]c3ccccc23)CCCc2ccccc12
Show InChI InChI=1S/C25H29N3O/c29-25-21-8-2-1-6-19(21)7-5-13-28(25)17-16-27-14-11-20(12-15-27)23-18-26-24-10-4-3-9-22(23)24/h1-4,6,8-10,18,20,26H,5,7,11-17H2
Reactome pathway
KEGG

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.70n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 2A receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50222894
PNG
(CHEMBL9952)
Show SMILES O=C1N(CCN2CCC(CC2)n2ccc3ccccc23)CCCc2ccccc12
Show InChI InChI=1S/C25H29N3O/c29-25-23-9-3-1-6-20(23)8-5-14-27(25)19-18-26-15-12-22(13-16-26)28-17-11-21-7-2-4-10-24(21)28/h1-4,6-7,9-11,17,22H,5,8,12-16,18-19H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.80n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50222893
PNG
(CHEMBL9250)
Show SMILES Fc1ccc2n(C3CCN(CCN4CCCc5ccccc5C4=O)CC3)c(=O)oc2c1
Show InChI InChI=1S/C24H26FN3O3/c25-18-7-8-21-22(16-18)31-24(30)28(21)19-9-12-26(13-10-19)14-15-27-11-3-5-17-4-1-2-6-20(17)23(27)29/h1-2,4,6-8,16,19H,3,5,9-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
9.30n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50222890
PNG
(CHEMBL9840)
Show SMILES COc1ccccc1C1CCN(CC2CCc3ccccc3C(=O)C2)CC1
Show InChI InChI=1S/C24H29NO2/c1-27-24-9-5-4-8-22(24)20-12-14-25(15-13-20)17-18-10-11-19-6-2-3-7-21(19)23(26)16-18/h2-9,18,20H,10-17H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
11n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50222896
PNG
(CHEMBL275475)
Show SMILES O=C1N(CCN2CCC(CC2)n2nnc3ccccc23)CCCc2ccccc12
Show InChI InChI=1S/C23H27N5O/c29-23-20-8-2-1-6-18(20)7-5-13-27(23)17-16-26-14-11-19(12-15-26)28-22-10-4-3-9-21(22)24-25-28/h1-4,6,8-10,19H,5,7,11-17H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
14n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50222894
PNG
(CHEMBL9952)
Show SMILES O=C1N(CCN2CCC(CC2)n2ccc3ccccc23)CCCc2ccccc12
Show InChI InChI=1S/C25H29N3O/c29-25-23-9-3-1-6-20(23)8-5-14-27(25)19-18-26-15-12-22(13-16-26)28-17-11-21-7-2-4-10-24(21)28/h1-4,6-7,9-11,17,22H,5,8,12-16,18-19H2
Reactome pathway
KEGG

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
19n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 2A receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50222895
PNG
(CHEMBL9564)
Show SMILES O=C1N(CCN2CCC(CC2)Oc2ccccc2)CCCc2ccccc12
Show InChI InChI=1S/C23H28N2O2/c26-23-22-11-5-4-7-19(22)8-6-14-25(23)18-17-24-15-12-21(13-16-24)27-20-9-2-1-3-10-20/h1-5,7,9-11,21H,6,8,12-18H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
20n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50222898
PNG
(CHEMBL9615)
Show SMILES O=C1C(CCN2CCC(CC2)Oc2ccccc2)CCCc2ccccc12
Show InChI InChI=1S/C24H29NO2/c26-24-20(9-6-8-19-7-4-5-12-23(19)24)13-16-25-17-14-22(15-18-25)27-21-10-2-1-3-11-21/h1-5,7,10-12,20,22H,6,8-9,13-18H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
25n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50222891
PNG
(CHEMBL273821)
Show SMILES O=C1N(CCN2CCC(CC2)n2c3ccccc3oc2=O)CCCc2ccccc12
Show InChI InChI=1S/C24H27N3O3/c28-23-20-8-2-1-6-18(20)7-5-13-26(23)17-16-25-14-11-19(12-15-25)27-21-9-3-4-10-22(21)30-24(27)29/h1-4,6,8-10,19H,5,7,11-17H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
28n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50222895
PNG
(CHEMBL9564)
Show SMILES O=C1N(CCN2CCC(CC2)Oc2ccccc2)CCCc2ccccc12
Show InChI InChI=1S/C23H28N2O2/c26-23-22-11-5-4-7-19(22)8-6-14-25(23)18-17-24-15-12-21(13-16-24)27-20-9-2-1-3-10-20/h1-5,7,9-11,21H,6,8,12-18H2
Reactome pathway
KEGG

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
155n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 2A receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50222893
PNG
(CHEMBL9250)
Show SMILES Fc1ccc2n(C3CCN(CCN4CCCc5ccccc5C4=O)CC3)c(=O)oc2c1
Show InChI InChI=1S/C24H26FN3O3/c25-18-7-8-21-22(16-18)31-24(30)28(21)19-9-12-26(13-10-19)14-15-27-11-3-5-17-4-1-2-6-20(17)23(27)29/h1-2,4,6-8,16,19H,3,5,9-15H2
Reactome pathway
KEGG

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
186n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 2A receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50222896
PNG
(CHEMBL275475)
Show SMILES O=C1N(CCN2CCC(CC2)n2nnc3ccccc23)CCCc2ccccc12
Show InChI InChI=1S/C23H27N5O/c29-23-20-8-2-1-6-18(20)7-5-13-27(23)17-16-26-14-11-19(12-15-26)28-22-10-4-3-9-21(22)24-25-28/h1-4,6,8-10,19H,5,7,11-17H2
Reactome pathway
KEGG

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
269n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 2A receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50222891
PNG
(CHEMBL273821)
Show SMILES O=C1N(CCN2CCC(CC2)n2c3ccccc3oc2=O)CCCc2ccccc12
Show InChI InChI=1S/C24H27N3O3/c28-23-20-8-2-1-6-18(20)7-5-13-26(23)17-16-25-14-11-19(12-15-25)27-21-9-3-4-10-22(21)30-24(27)29/h1-4,6,8-10,19H,5,7,11-17H2
Reactome pathway
KEGG

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
977n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity at human cloned 5-hydroxytryptamine 2A receptor.


Bioorg Med Chem Lett 13: 1055-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00077-5
BindingDB Entry DOI: 10.7270/Q2X066D4
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4.10E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation activity at muscarinic M5 receptor


J Med Chem 55: 1445-64 (2012)


Article DOI: 10.1021/jm201139r
BindingDB Entry DOI: 10.7270/Q25D8SWH
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.00E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation activity at muscarinic M1 receptor


J Med Chem 55: 1445-64 (2012)


Article DOI: 10.1021/jm201139r
BindingDB Entry DOI: 10.7270/Q25D8SWH
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.40E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation activity at muscarinic M3 receptor


J Med Chem 55: 1445-64 (2012)


Article DOI: 10.1021/jm201139r
BindingDB Entry DOI: 10.7270/Q25D8SWH
More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Homo sapiens (Human))
BDBM50222911
PNG
(CHEMBL18436)
Show SMILES CCCCn1ncnc1-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C16H22N6/c1-2-3-10-22-16(20-12-21-22)13-6-4-5-7-14(13)19-11-15-17-8-9-18-15/h4-7,12,19H,2-3,8-11H2,1H3,(H,17,18)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 200n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50222911
PNG
(CHEMBL18436)
Show SMILES CCCCn1ncnc1-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C16H22N6/c1-2-3-10-22-16(20-12-21-22)13-6-4-5-7-14(13)19-11-15-17-8-9-18-15/h4-7,12,19H,2-3,8-11H2,1H3,(H,17,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 200n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Homo sapiens (Human))
BDBM50222910
PNG
(CHEMBL17491)
Show SMILES C(Nc1ccccc1-c1nc[nH]n1)C1=NCCN1
Show InChI InChI=1S/C12H14N6/c1-2-4-10(15-7-11-13-5-6-14-11)9(3-1)12-16-8-17-18-12/h1-4,8,15H,5-7H2,(H,13,14)(H,16,17,18)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 5n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Homo sapiens (Human))
BDBM50222909
PNG
(CHEMBL276733)
Show SMILES CCn1cc(cn1)-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C15H19N5/c1-2-20-11-12(9-19-20)13-5-3-4-6-14(13)18-10-15-16-7-8-17-15/h3-6,9,11,18H,2,7-8,10H2,1H3,(H,16,17)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a<1.00E+5n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Homo sapiens (Human))
BDBM50222904
PNG
(CHEMBL417999)
Show SMILES CCn1ccc(n1)-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C15H19N5/c1-2-20-10-7-14(19-20)12-5-3-4-6-13(12)18-11-15-16-8-9-17-15/h3-7,10,18H,2,8-9,11H2,1H3,(H,16,17)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a<1.00E+5n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Homo sapiens (Human))
BDBM50222903
PNG
(CHEMBL17776)
Show SMILES CCCn1ncnc1-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C15H20N6/c1-2-9-21-15(19-11-20-21)12-5-3-4-6-13(12)18-10-14-16-7-8-17-14/h3-6,11,18H,2,7-10H2,1H3,(H,16,17)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 316n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(Homo sapiens (Human))
BDBM50222906
PNG
(CHEMBL277361)
Show SMILES FC(F)(F)Cn1nccc1-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C15H16F3N5/c16-15(17,18)10-23-13(5-6-22-23)11-3-1-2-4-12(11)21-9-14-19-7-8-20-14/h1-6,21H,7-10H2,(H,19,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a<1.00E+5n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50222909
PNG
(CHEMBL276733)
Show SMILES CCn1cc(cn1)-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C15H19N5/c1-2-20-11-12(9-19-20)13-5-3-4-6-14(13)18-10-15-16-7-8-17-15/h3-6,9,11,18H,2,7-8,10H2,1H3,(H,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a<1.00E+5n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Homo sapiens (Human))
BDBM50222906
PNG
(CHEMBL277361)
Show SMILES FC(F)(F)Cn1nccc1-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C15H16F3N5/c16-15(17,18)10-23-13(5-6-22-23)11-3-1-2-4-12(11)21-9-14-19-7-8-20-14/h1-6,21H,7-10H2,(H,19,20)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a<1.00E+5n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of human alpha-1B adrenergic receptor, expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50222910
PNG
(CHEMBL17491)
Show SMILES C(Nc1ccccc1-c1nc[nH]n1)C1=NCCN1
Show InChI InChI=1S/C12H14N6/c1-2-4-10(15-7-11-13-5-6-14-11)9(3-1)12-16-8-17-18-12/h1-4,8,15H,5-7H2,(H,13,14)(H,16,17,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.794n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50222904
PNG
(CHEMBL417999)
Show SMILES CCn1ccc(n1)-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C15H19N5/c1-2-20-10-7-14(19-20)12-5-3-4-6-13(12)18-11-15-16-8-9-17-15/h3-7,10,18H,2,8-9,11H2,1H3,(H,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 25n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50222906
PNG
(CHEMBL277361)
Show SMILES FC(F)(F)Cn1nccc1-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C15H16F3N5/c16-15(17,18)10-23-13(5-6-22-23)11-3-1-2-4-12(11)21-9-14-19-7-8-20-14/h1-6,21H,7-10H2,(H,19,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 316n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(Homo sapiens (Human))
BDBM50222903
PNG
(CHEMBL17776)
Show SMILES CCCn1ncnc1-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C15H20N6/c1-2-9-21-15(19-11-20-21)12-5-3-4-6-13(12)18-10-14-16-7-8-17-14/h3-6,11,18H,2,7-10H2,1H3,(H,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 251n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(Homo sapiens (Human))
BDBM50222904
PNG
(CHEMBL417999)
Show SMILES CCn1ccc(n1)-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C15H19N5/c1-2-20-10-7-14(19-20)12-5-3-4-6-13(12)18-11-15-16-8-9-17-15/h3-7,10,18H,2,8-9,11H2,1H3,(H,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a<1.00E+5n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Homo sapiens (Human))
BDBM50222903
PNG
(CHEMBL17776)
Show SMILES CCCn1ncnc1-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C15H20N6/c1-2-9-21-15(19-11-20-21)12-5-3-4-6-13(12)18-10-14-16-7-8-17-14/h3-6,11,18H,2,7-10H2,1H3,(H,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 13n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(Homo sapiens (Human))
BDBM50222909
PNG
(CHEMBL276733)
Show SMILES CCn1cc(cn1)-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C15H19N5/c1-2-20-11-12(9-19-20)13-5-3-4-6-14(13)18-10-15-16-7-8-17-15/h3-6,9,11,18H,2,7-8,10H2,1H3,(H,16,17)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a<1.00E+5n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(Homo sapiens (Human))
BDBM50222910
PNG
(CHEMBL17491)
Show SMILES C(Nc1ccccc1-c1nc[nH]n1)C1=NCCN1
Show InChI InChI=1S/C12H14N6/c1-2-4-10(15-7-11-13-5-6-14-11)9(3-1)12-16-8-17-18-12/h1-4,8,15H,5-7H2,(H,13,14)(H,16,17,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4.60E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M5 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...


Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as effect on acetylcholine-induced intrac...


Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.40E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M3 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...


Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as effect on acetylcholine-induced intrac...


Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.10E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium mob...


Bioorg Med Chem Lett 20: 5617-22 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.042
BindingDB Entry DOI: 10.7270/Q2CR5TK2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4.10E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M5 expressed in CHO cells assessed as stimulation of calcium mobilization


Bioorg Med Chem Lett 20: 558-62 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.089
BindingDB Entry DOI: 10.7270/Q2PK0G7M
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(RAT)
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at rat muscarinic M4 expressed in CHO cells assessed as stimulation of calcium mobilization


Bioorg Med Chem Lett 20: 558-62 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.089
BindingDB Entry DOI: 10.7270/Q2PK0G7M
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.40E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human muscarinic M3 expressed in CHO cells assessed as stimulation of calcium mobilization


Bioorg Med Chem Lett 20: 558-62 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.089
BindingDB Entry DOI: 10.7270/Q2PK0G7M
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization


Bioorg Med Chem Lett 20: 558-62 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.089
BindingDB Entry DOI: 10.7270/Q2PK0G7M
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.10E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at rat muscarinic M1 expressed in CHO cells assessed as stimulation of calcium mobilization


Bioorg Med Chem Lett 20: 558-62 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.089
BindingDB Entry DOI: 10.7270/Q2PK0G7M
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M5 chimeric protein


(Homo sapiens (Human))
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4.08E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of human muscarinic M5 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracell...


J Med Chem 52: 3445-8 (2009)


Article DOI: 10.1021/jm900286j
BindingDB Entry DOI: 10.7270/Q23B601Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.38E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of human muscarinic M3 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracell...


J Med Chem 52: 3445-8 (2009)


Article DOI: 10.1021/jm900286j
BindingDB Entry DOI: 10.7270/Q23B601Q
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(Homo sapiens (Human))
BDBM50222911
PNG
(CHEMBL18436)
Show SMILES CCCCn1ncnc1-c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C16H22N6/c1-2-3-10-22-16(20-12-21-22)13-6-4-5-7-14(13)19-11-15-17-8-9-18-15/h4-7,12,19H,2-3,8-11H2,1H3,(H,17,18)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 398n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells


Bioorg Med Chem Lett 13: 1183-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00050-7
BindingDB Entry DOI: 10.7270/Q21V5G8T
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/an/an/a 6.04E+3n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Muscarinic acetylcholine receptors are family A GPCRs comprised of...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2K64GH0
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50258439
PNG
(1-(4-bromobenzyl)indoline-2,3-dione | CHEMBL523685...)
Show SMILES Brc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.04E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of rat muscarinic M1 receptor expressed in CHO cells coexpressing Gq protein assessed as potentiation of acetylcholine-induced intracellul...


J Med Chem 52: 3445-8 (2009)


Article DOI: 10.1021/jm900286j
BindingDB Entry DOI: 10.7270/Q23B601Q
More data for this
Ligand-Target Pair