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1 similar compounds to monomer 50114097

Compile data set for download or QSAR
Wt: 653.3
BDBM50226768

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50226768   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
S-adenosylmethionine synthetase (MAT 1 and MAT 2)


(Rattus norvegicus)
BDBM50226768
PNG
(CHEMBL1791426)
Show SMILES NC(CCS[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1
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270n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of ATP varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
More data for this
Ligand-Target Pair
S-adenosylmethionine synthetase (MAT 1 and MAT 2)


(Rattus norvegicus)
BDBM50226768
PNG
(CHEMBL1791426)
Show SMILES NC(CCS[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1
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360n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of ATP varied compound was measured on M-2 variate methionine adenosyltransferase in rat kidney


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
More data for this
Ligand-Target Pair
S-adenosylmethionine synthetase (MAT 1 and MAT 2)


(Rattus norvegicus)
BDBM50226768
PNG
(CHEMBL1791426)
Show SMILES NC(CCS[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1
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2.30E+3n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of Met varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
More data for this
Ligand-Target Pair
S-adenosylmethionine synthetase (MAT 1 and MAT 2)


(Rattus norvegicus)
BDBM50226768
PNG
(CHEMBL1791426)
Show SMILES NC(CCS[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1
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Article
PubMed
3.00E+3n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of Met varied compound was measured on M-2 variant methionine adenosyltransferase in rat kidney


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
More data for this
Ligand-Target Pair
S-adenosylmethionine synthetase (MAT 1 and MAT 2)


(Rattus norvegicus)
BDBM50226768
PNG
(CHEMBL1791426)
Show SMILES NC(CCS[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1
PDB

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Article
PubMed
2.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant of compound with Novikoff ascitic hepatoma (M-T) form of rat methionine adenosyltransferase when ATP was used as variable substra...


J Med Chem 30: 888-94 (1987)


Article DOI: 10.1021/jm00388a024
More data for this
Ligand-Target Pair