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3 similar compounds to monomer 50247784

Wt: 502.9
BDBM50247785
Wt: 479.9
BDBM50247786
Wt: 448.8
BDBM50247796

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50247785,50247786,50247796   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247785
PNG
((3S,4R)-4-(5-Chloro-benzo[d]isoxazol-3-ylamino)-6-...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H](Nc2noc3ccc(Cl)cc23)[C@@H]1O)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C24H20ClFN2O5S/c1-24(2)22(29)21(27-23-18-10-13(25)6-8-20(18)33-28-23)17-12-16(7-9-19(17)32-24)34(30,31)15-5-3-4-14(26)11-15/h3-12,21-22,29H,1-2H3,(H,27,28)/t21-,22+/m1/s1
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Article
PubMed
n/an/an/an/a 7.77E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247796
PNG
((3S,4R)-4-(5-Chloro-benzo[d]isoxazol-3-ylamino)-3S...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H](Nc2noc3ccc(Cl)cc23)[C@@H]1O)C(=O)c1ccccc1
Show InChI InChI=1S/C25H21ClN2O4/c1-25(2)23(30)21(27-24-18-13-16(26)9-11-20(18)32-28-24)17-12-15(8-10-19(17)31-25)22(29)14-6-4-3-5-7-14/h3-13,21,23,30H,1-2H3,(H,27,28)/t21-,23+/m1/s1
Reactome pathway
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antibodypedia
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PC cid
PC sid
UniChem

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Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2.04E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247786
PNG
((3S,4R)-4-(5-Chloro-benzo[d]isoxazol-3-ylamino)-3-...)
Show SMILES CCN(CC)S(=O)(=O)c1ccc2OC(C)(C)[C@@H](O)[C@H](Nc3noc4ccc(Cl)cc34)c2c1
Show InChI InChI=1S/C22H26ClN3O5S/c1-5-26(6-2)32(28,29)14-8-10-17-15(12-14)19(20(27)22(3,4)30-17)24-21-16-11-13(23)7-9-18(16)31-25-21/h7-12,19-20,27H,5-6H2,1-4H3,(H,24,25)/t19-,20+/m1/s1
Reactome pathway
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DrugBank
antibodypedia
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AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair