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7 similar compounds to monomer 50247834

Wt: 370.7
BDBM50247799
Wt: 485.9
BDBM50247817
Wt: 485.9
BDBM50247818
Wt: 492.9
BDBM50247833
Wt: 515.9
BDBM50247858
Wt: 520.3
BDBM50247859
Wt: 503.9
BDBM50247860

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50247799,50247817,50247818,50247833,50247858,50247859,50247860   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247799
PNG
((3S,4R)-4-(5-chloro-3-oxobenzo[d]isoxazol-2(3H)-yl...)
Show SMILES CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)n1oc2ccc(Cl)cc2c1=O)C#N
Show InChI InChI=1S/C19H15ClN2O4/c1-19(2)17(23)16(12-7-10(9-21)3-5-14(12)25-19)22-18(24)13-8-11(20)4-6-15(13)26-22/h3-8,16-17,23H,1-2H3/t16-,17+/m1/s1
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Article
PubMed
n/an/an/an/a 2.44E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247817
PNG
((3S,4R)-2-(6-Benzenesulfonyl-3-hydroxy-2,2-dimethy...)
Show SMILES CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)n1oc2cc(Cl)ccc2c1=O)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H20ClNO6S/c1-24(2)22(27)21(26-23(28)17-10-8-14(25)12-20(17)32-26)18-13-16(9-11-19(18)31-24)33(29,30)15-6-4-3-5-7-15/h3-13,21-22,27H,1-2H3/t21-,22+/m1/s1
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n/an/an/an/a 750n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247818
PNG
((3S,4R)-2-(6-Benzenesulfonyl-3-hydroxy-2,2-dimethy...)
Show SMILES CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)n1oc2ccc(Cl)cc2c1=O)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C24H20ClNO6S/c1-24(2)22(27)21(26-23(28)18-12-14(25)8-10-20(18)32-26)17-13-16(9-11-19(17)31-24)33(29,30)15-6-4-3-5-7-15/h3-13,21-22,27H,1-2H3/t21-,22+/m1/s1
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PubMed
n/an/an/an/a 1.56E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247860
PNG
((3S,4R)-6-Chloro-2-[6-(3-fluoro-benzenesulfonyl)-3...)
Show SMILES CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)n1oc2cc(Cl)ccc2c1=O)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C24H19ClFNO6S/c1-24(2)22(28)21(27-23(29)17-8-6-13(25)10-20(17)33-27)18-12-16(7-9-19(18)32-24)34(30,31)15-5-3-4-14(26)11-15/h3-12,21-22,28H,1-2H3/t21-,22+/m1/s1
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PubMed
n/an/an/an/a 1.71E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247858
PNG
((3S,4R)-6-Chloro-[2-hydroxy-6-(4-methoxy-benzenesu...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccc2OC(C)(C)[C@@H](O)[C@@H](c2c1)n1oc2cc(Cl)ccc2c1=O
Show InChI InChI=1S/C25H22ClNO7S/c1-25(2)23(28)22(27-24(29)18-10-4-14(26)12-21(18)34-27)19-13-17(9-11-20(19)33-25)35(30,31)16-7-5-15(32-3)6-8-16/h4-13,22-23,28H,1-3H3/t22-,23+/m1/s1
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Article
PubMed
n/an/an/an/a 7.33E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247859
PNG
((3S,4R)-6-Chloro-2-[6-(4-chloro-benzenesulfonyl)-3...)
Show SMILES CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)n1oc2cc(Cl)ccc2c1=O)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H19Cl2NO6S/c1-24(2)22(28)21(27-23(29)17-9-5-14(26)11-20(17)33-27)18-12-16(8-10-19(18)32-24)34(30,31)15-6-3-13(25)4-7-15/h3-12,21-22,28H,1-2H3/t21-,22+/m1/s1
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Article
PubMed
n/an/an/an/a 7.99E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247833
PNG
((3S,4R)-6-Chloro-2-[3-hydroxy-2,2-dimethyl-6-(pipe...)
Show SMILES CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)n1oc2cc(Cl)ccc2c1=O)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C23H25ClN2O6S/c1-23(2)21(27)20(26-22(28)16-8-6-14(24)12-19(16)32-26)17-13-15(7-9-18(17)31-23)33(29,30)25-10-4-3-5-11-25/h6-9,12-13,20-21,27H,3-5,10-11H2,1-2H3/t20-,21+/m1/s1
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Article
PubMed
n/an/an/an/a 1.08E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair