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32 similar compounds to monomer 50248531

Wt: 480.4
BDBM50248579
Wt: 527.9
BDBM50248580
Wt: 563.9
BDBM50248581
Wt: 528.9
BDBM50248582
Wt: 488.8
BDBM50247935
Wt: 529.8
BDBM50247936
Wt: 528.9
BDBM50247937
Wt: 494.4
BDBM50247938
Wt: 562.4
BDBM50248068
Wt: 519.4
BDBM50248069
Wt: 508.4
BDBM50248070
Wt: 512.4
BDBM50248071
Wt: 552.9
BDBM50247965
Wt: 484.8
BDBM50248022
Wt: 562.3
BDBM50248023
Displayed 1 to 15 (of 32 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50248579,50248580,50248581,50248582,50247935,50247936,50247937,50247938,50248068,50248069,50248070,50248071,50247965,50248022,50248023   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50247935
PNG
((R)-2-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)...)
Show SMILES C[C@@H](Nc1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C19H13ClF4N4O3S/c1-8(17(30)31)26-15-12(20)5-9(6-25-15)16(29)28-18-27-13(7-32-18)10-3-2-4-11(14(10)21)19(22,23)24/h2-8H,1H3,(H,25,26)(H,30,31)(H,27,28,29)/t8-/m1/s1
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n/an/an/an/a 57n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248582
PNG
((4R)-1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl...)
Show SMILES C[C@H]1CN(CC1C(O)=O)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O3S/c1-10-7-31(8-13(10)20(33)34)18-15(23)5-11(6-28-18)19(32)30-21-29-16(9-35-21)12-3-2-4-14(17(12)24)22(25,26)27/h2-6,9-10,13H,7-8H2,1H3,(H,33,34)(H,29,30,32)/t10-,13?/m0/s1
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n/an/an/an/a 43n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50247937
PNG
(1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phen...)
Show SMILES OC(=O)C1CCCN(C1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O3S/c23-15-7-12(8-28-18(15)31-6-2-3-11(9-31)20(33)34)19(32)30-21-29-16(10-35-21)13-4-1-5-14(17(13)24)22(25,26)27/h1,4-5,7-8,10-11H,2-3,6,9H2,(H,33,34)(H,29,30,32)
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n/an/an/an/a 294n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50247938
PNG
(1-(5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazo...)
Show SMILES OC(=O)C1CCN(CC1)c1ccc(cn1)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H18F4N4O3S/c23-18-14(2-1-3-15(18)22(24,25)26)16-11-34-21(28-16)29-19(31)13-4-5-17(27-10-13)30-8-6-12(7-9-30)20(32)33/h1-5,10-12H,6-9H2,(H,32,33)(H,28,29,31)
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n/an/an/an/a 430n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50247965
PNG
(6-(4-(2H-tetrazol-5-yl)piperidin-1-yl)-5-chloro-N-...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2cnc(N3CCC(CC3)c3nnn[nH]3)c(Cl)c2)n1
Show InChI InChI=1S/C22H17ClF4N8OS/c23-15-8-12(9-28-19(15)35-6-4-11(5-7-35)18-31-33-34-32-18)20(36)30-21-29-16(10-37-21)13-2-1-3-14(17(13)24)22(25,26)27/h1-3,8-11H,4-7H2,(H,29,30,36)(H,31,32,33,34)
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n/an/an/an/a 485n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248022
PNG
(5-chloro-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2cnc(N3CCCCC3)c(Cl)c2)n1
Show InChI InChI=1S/C21H17ClF4N4OS/c22-15-9-12(10-27-18(15)30-7-2-1-3-8-30)19(31)29-20-28-16(11-32-20)13-5-4-6-14(17(13)23)21(24,25)26/h4-6,9-11H,1-3,7-8H2,(H,28,29,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248023
PNG
(1-(2,6-dichloro-4-(4-(2-fluoro-3-(trifluoromethyl)...)
Show SMILES OC(=O)C1CCN(CC1)c1c(Cl)cc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C23H17Cl2F4N3O3S/c24-15-8-12(9-16(25)19(15)32-6-4-11(5-7-32)21(34)35)20(33)31-22-30-17(10-36-22)13-2-1-3-14(18(13)26)23(27,28)29/h1-3,8-11H,4-7H2,(H,34,35)(H,30,31,33)
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n/an/an/an/a 10n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248068
PNG
(1-(5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazo...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1C(F)(F)F)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C23H17F7N4O3S/c24-17-13(2-1-3-14(17)22(25,26)27)16-10-38-21(32-16)33-19(35)12-8-15(23(28,29)30)18(31-9-12)34-6-4-11(5-7-34)20(36)37/h1-3,8-11H,4-7H2,(H,36,37)(H,32,33,35)
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n/an/an/an/a 134n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248069
PNG
(1-(3-cyano-5-(4-(2-fluoro-3-(trifluoromethyl)pheny...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1C#N)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C23H17F4N5O3S/c24-18-15(2-1-3-16(18)23(25,26)27)17-11-36-22(30-17)31-20(33)14-8-13(9-28)19(29-10-14)32-6-4-12(5-7-32)21(34)35/h1-3,8,10-12H,4-7H2,(H,34,35)(H,30,31,33)
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n/an/an/an/a 138n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248070
PNG
(1-(5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazo...)
Show SMILES Cc1cc(cnc1N1CCC(CC1)C(O)=O)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C23H20F4N4O3S/c1-12-9-14(10-28-19(12)31-7-5-13(6-8-31)21(33)34)20(32)30-22-29-17(11-35-22)15-3-2-4-16(18(15)24)23(25,26)27/h2-4,9-11,13H,5-8H2,1H3,(H,33,34)(H,29,30,32)
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n/an/an/an/a 253n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248071
PNG
(1-(3-fluoro-5-(4-(2-fluoro-3-(trifluoromethyl)phen...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1F)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H17F5N4O3S/c23-15-8-12(9-28-18(15)31-6-4-11(5-7-31)20(33)34)19(32)30-21-29-16(10-35-21)13-2-1-3-14(17(13)24)22(25,26)27/h1-3,8-11H,4-7H2,(H,33,34)(H,29,30,32)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248579
PNG
(1-(5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazo...)
Show SMILES OC(=O)C1CCN(C1)c1ccc(cn1)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C21H16F4N4O3S/c22-17-13(2-1-3-14(17)21(23,24)25)15-10-33-20(27-15)28-18(30)11-4-5-16(26-8-11)29-7-6-12(9-29)19(31)32/h1-5,8,10,12H,6-7,9H2,(H,31,32)(H,27,28,30)
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n/an/an/an/a 3.30E+3n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248580
PNG
(6-(4-carbamoylpiperidin-1-yl)-5-chloro-N-(4-(2-flu...)
Show SMILES NC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H18ClF4N5O2S/c23-15-8-12(9-29-19(15)32-6-4-11(5-7-32)18(28)33)20(34)31-21-30-16(10-35-21)13-2-1-3-14(17(13)24)22(25,26)27/h1-3,8-11H,4-7H2,(H2,28,33)(H,30,31,34)
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n/an/an/an/a 28n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248581
PNG
(5-chloro-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)...)
Show SMILES NS(=O)(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C21H18ClF4N5O3S2/c22-15-8-11(9-28-18(15)31-6-4-12(5-7-31)36(27,33)34)19(32)30-20-29-16(10-35-20)13-2-1-3-14(17(13)23)21(24,25)26/h1-3,8-10,12H,4-7H2,(H2,27,33,34)(H,29,30,32)
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n/an/an/an/a 34n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50247936
PNG
(4-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phen...)
Show SMILES OC(=O)C1CN(CCN1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O3S/c22-13-6-10(7-28-17(13)31-5-4-27-14(8-31)19(33)34)18(32)30-20-29-15(9-35-20)11-2-1-3-12(16(11)23)21(24,25)26/h1-3,6-7,9,14,27H,4-5,8H2,(H,33,34)(H,29,30,32)
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n/an/an/an/a 129n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair