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32 molecules are shown

Wt: 573.3
BDBM50248024
Wt: 524.4
BDBM50248105
Wt: 527.9
BDBM50248025
Wt: 546.8
BDBM50321628
Wt: 528.9
BDBM50321629
Wt: 546.8
BDBM50321630
Wt: 542.9
BDBM50321631
Wt: 563.3
BDBM50321632
Wt: 556.9
BDBM50321633
Wt: 570.9
BDBM50321634
Wt: 553.9
BDBM50321635
Wt: 513.3
BDBM50321638
Wt: 557.7
BDBM50321639
Wt: 529.7
BDBM50321640
Wt: 536.9
BDBM50321643
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50248024,50248105,50248025,50321628,50321629,50321630,50321631,50321632,50321633,50321634,50321635,50321638,50321639,50321640,50321643   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50248024
PNG
(1-(3-bromo-5-(4-(2-fluoro-3-(trifluoromethyl)pheny...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Br)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H17BrF4N4O3S/c23-15-8-12(9-28-18(15)31-6-4-11(5-7-31)20(33)34)19(32)30-21-29-16(10-35-21)13-2-1-3-14(17(13)24)22(25,26)27/h1-3,8-11H,4-7H2,(H,33,34)(H,29,30,32)
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n/an/an/an/a 50n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Bioorg Med Chem Lett 19: 1428-30 (2009)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50321635
PNG
(1-(3-chloro-5-(5-cyano-4-(4-fluoro-3-(trifluoromet...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(c(s1)C#N)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H16ClF4N5O3S/c24-15-8-13(10-30-19(15)33-5-3-11(4-6-33)21(35)36)20(34)32-22-31-18(17(9-29)37-22)12-1-2-16(25)14(7-12)23(26,27)28/h1-2,7-8,10-11H,3-6H2,(H,35,36)(H,31,32,34)
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n/an/an/an/a>898n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human TPO receptor expressed in rat BaF3 cells


Bioorg Med Chem Lett 20: 4069-72 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248105
PNG
(1-(5-(4-(2-fluoro-3-(trifluoromethyl)phenyl)thiazo...)
Show SMILES COc1cc(cnc1N1CCC(CC1)C(O)=O)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C23H20F4N4O4S/c1-35-17-9-13(10-28-19(17)31-7-5-12(6-8-31)21(33)34)20(32)30-22-29-16(11-36-22)14-3-2-4-15(18(14)24)23(25,26)27/h2-4,9-12H,5-8H2,1H3,(H,33,34)(H,29,30,32)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Bioorg Med Chem Lett 19: 1428-30 (2009)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50321638
PNG
(1-(3-chloro-5-(4-(3-chloro-4-fluorophenyl)-5-fluor...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(c(F)s1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C21H16Cl2F2N4O3S/c22-13-7-11(1-2-15(13)24)16-17(25)33-21(27-16)28-19(30)12-8-14(23)18(26-9-12)29-5-3-10(4-6-29)20(31)32/h1-2,7-10H,3-6H2,(H,31,32)(H,27,28,30)
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n/an/an/an/a 480n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human TPO receptor expressed in rat BaF3 cells


Bioorg Med Chem Lett 20: 4069-72 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50321639
PNG
(1-(5-(4-(3-bromo-4-fluorophenyl)-5-fluorothiazol-2...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(c(F)s1)-c1ccc(F)c(Br)c1
Show InChI InChI=1S/C21H16BrClF2N4O3S/c22-13-7-11(1-2-15(13)24)16-17(25)33-21(27-16)28-19(30)12-8-14(23)18(26-9-12)29-5-3-10(4-6-29)20(31)32/h1-2,7-10H,3-6H2,(H,31,32)(H,27,28,30)
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n/an/an/an/a 670n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human TPO receptor expressed in rat BaF3 cells


Bioorg Med Chem Lett 20: 4069-72 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50321640
PNG
(1-(3-chloro-5-(4-(3,4-dichlorophenyl)-5-fluorothia...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(c(F)s1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H16Cl3FN4O3S/c22-13-2-1-11(7-14(13)23)16-17(25)33-21(27-16)28-19(30)12-8-15(24)18(26-9-12)29-5-3-10(4-6-29)20(31)32/h1-2,7-10H,3-6H2,(H,31,32)(H,27,28,30)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human TPO receptor expressed in rat BaF3 cells


Bioorg Med Chem Lett 20: 4069-72 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50321643
PNG
(1-(3-chloro-5-(4-(3-(ethoxymethyl)-4-fluorophenyl)...)
Show SMILES CCOCc1cc(ccc1F)-c1nc(NC(=O)c2cnc(N3CCC(CC3)C(O)=O)c(Cl)c2)sc1F
Show InChI InChI=1S/C24H23ClF2N4O4S/c1-2-35-12-16-9-14(3-4-18(16)26)19-20(27)36-24(29-19)30-22(32)15-10-17(25)21(28-11-15)31-7-5-13(6-8-31)23(33)34/h3-4,9-11,13H,2,5-8,12H2,1H3,(H,33,34)(H,29,30,32)
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n/an/an/an/a>970n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human TPO receptor expressed in rat BaF3 cells


Bioorg Med Chem Lett 20: 4069-72 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50321628
PNG
(1-(3-chloro-5-(5-fluoro-4-(2-fluoro-3-(trifluorome...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(c(F)s1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H16ClF5N4O3S/c23-14-8-11(9-29-18(14)32-6-4-10(5-7-32)20(34)35)19(33)31-21-30-16(17(25)36-21)12-2-1-3-13(15(12)24)22(26,27)28/h1-3,8-10H,4-7H2,(H,34,35)(H,30,31,33)
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n/an/an/an/a 702n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human TPO receptor expressed in rat BaF3 cells


Bioorg Med Chem Lett 20: 4069-72 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50321629
PNG
(1-(3-chloro-5-(4-(4-fluoro-3-(trifluoromethyl)phen...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O3S/c23-15-8-13(9-28-18(15)31-5-3-11(4-6-31)20(33)34)19(32)30-21-29-17(10-35-21)12-1-2-16(24)14(7-12)22(25,26)27/h1-2,7-11H,3-6H2,(H,33,34)(H,29,30,32)
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n/an/an/an/a 100n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human TPO receptor expressed in rat BaF3 cells


Bioorg Med Chem Lett 20: 4069-72 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50321630
PNG
(1-(3-chloro-5-(5-fluoro-4-(4-fluoro-3-(trifluorome...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(c(F)s1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H16ClF5N4O3S/c23-14-8-12(9-29-18(14)32-5-3-10(4-6-32)20(34)35)19(33)31-21-30-16(17(25)36-21)11-1-2-15(24)13(7-11)22(26,27)28/h1-2,7-10H,3-6H2,(H,34,35)(H,30,31,33)
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n/an/an/an/a 89n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human TPO receptor expressed in rat BaF3 cells


Bioorg Med Chem Lett 20: 4069-72 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50321631
PNG
(1-(3-chloro-5-(4-(4-fluoro-3-(trifluoromethyl)phen...)
Show SMILES Cc1sc(NC(=O)c2cnc(N3CCC(CC3)C(O)=O)c(Cl)c2)nc1-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H19ClF4N4O3S/c1-11-18(13-2-3-17(25)15(8-13)23(26,27)28)30-22(36-11)31-20(33)14-9-16(24)19(29-10-14)32-6-4-12(5-7-32)21(34)35/h2-3,8-10,12H,4-7H2,1H3,(H,34,35)(H,30,31,33)
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n/an/an/an/a 66n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human TPO receptor expressed in rat BaF3 cells


Bioorg Med Chem Lett 20: 4069-72 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50321632
PNG
(1-(3-chloro-5-(5-chloro-4-(4-fluoro-3-(trifluorome...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(c(Cl)s1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H16Cl2F4N4O3S/c23-14-8-12(9-29-18(14)32-5-3-10(4-6-32)20(34)35)19(33)31-21-30-16(17(24)36-21)11-1-2-15(25)13(7-11)22(26,27)28/h1-2,7-10H,3-6H2,(H,34,35)(H,30,31,33)
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n/an/an/an/a 86n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human TPO receptor expressed in rat BaF3 cells


Bioorg Med Chem Lett 20: 4069-72 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50321633
PNG
(1-(3-chloro-5-(5-ethyl-4-(4-fluoro-3-(trifluoromet...)
Show SMILES CCc1sc(NC(=O)c2cnc(N3CCC(CC3)C(O)=O)c(Cl)c2)nc1-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H21ClF4N4O3S/c1-2-18-19(13-3-4-17(26)15(9-13)24(27,28)29)31-23(37-18)32-21(34)14-10-16(25)20(30-11-14)33-7-5-12(6-8-33)22(35)36/h3-4,9-12H,2,5-8H2,1H3,(H,35,36)(H,31,32,34)
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n/an/an/an/a 160n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human TPO receptor expressed in rat BaF3 cells


Bioorg Med Chem Lett 20: 4069-72 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50321634
PNG
(1-(3-chloro-5-(4-(4-fluoro-3-(trifluoromethyl)phen...)
Show SMILES CCCc1sc(NC(=O)c2cnc(N3CCC(CC3)C(O)=O)c(Cl)c2)nc1-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H23ClF4N4O3S/c1-2-3-19-20(14-4-5-18(27)16(10-14)25(28,29)30)32-24(38-19)33-22(35)15-11-17(26)21(31-12-15)34-8-6-13(7-9-34)23(36)37/h4-5,10-13H,2-3,6-9H2,1H3,(H,36,37)(H,32,33,35)
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n/an/an/an/a 130n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human TPO receptor expressed in rat BaF3 cells


Bioorg Med Chem Lett 20: 4069-72 (2010)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248025
PNG
(1-(2-chloro-4-(4-(2-fluoro-3-(trifluoromethyl)phen...)
Show SMILES OC(=O)C1CCN(CC1)c1ccc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C23H18ClF4N3O3S/c24-16-10-13(4-5-18(16)31-8-6-12(7-9-31)21(33)34)20(32)30-22-29-17(11-35-22)14-2-1-3-15(19(14)25)23(26,27)28/h1-5,10-12H,6-9H2,(H,33,34)(H,29,30,32)
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n/an/an/an/a 56n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Bioorg Med Chem Lett 19: 1428-30 (2009)

More data for this
Ligand-Target Pair