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6 similar compounds to monomer 50252662

Compile data set for download or QSAR
Wt: 232.2
BDBM50252051
Wt: 246.2
BDBM50252052
Wt: 286.3
BDBM50426293
Wt: 274.3
BDBM50426294
Wt: 256.2
BDBM50426296
Wt: 246.2
BDBM50426299

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 53 hits for monomerid = 50252051,50252052,50426293,50426294,50426296,50426299   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate kainate


(RAT)
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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3.81n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat recombinant iGluR5


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50426299
PNG
(CHEMBL2312398)
Show SMILES CN(C)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-12(2)8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,3-5,11H2,1-2H3,(H,14,15)(H,16,17)/t6-,7+/s2
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37n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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57.3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat recombinant iGluR7


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate kainate


(RAT)
BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O
Show InChI InChI=1/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/s2
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96n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Rattus norvegicus)
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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123n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat recombinant iGluR6


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O
Show InChI InChI=1/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/s2
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185n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50426294
PNG
(CHEMBL2312399)
Show SMILES CCN(CC)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C12H22N2O5/c1-3-14(4-2)10(15)6-5-8(11(16)17)7-9(13)12(18)19/h8-9H,3-7,13H2,1-2H3,(H,16,17)(H,18,19)/t8-,9+/s2
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413n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O
Show InChI InChI=1/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/s2
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583n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50252052
PNG
((2S,4R)-2-amino-4-(3-(ethylamino)-3-oxopropyl)pent...)
Show SMILES CCNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-2-12-8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,2-5,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t6-,7+/s2
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641n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat recombinant iGluR5


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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>3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50252052
PNG
((2S,4R)-2-amino-4-(3-(ethylamino)-3-oxopropyl)pent...)
Show SMILES CCNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-2-12-8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,2-5,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t6-,7+/s2
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3.24E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat recombinant iGluR7


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50426294
PNG
(CHEMBL2312399)
Show SMILES CCN(CC)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C12H22N2O5/c1-3-14(4-2)10(15)6-5-8(11(16)17)7-9(13)12(18)19/h8-9H,3-7,13H2,1-2H3,(H,16,17)(H,18,19)/t8-,9+/s2
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3.29E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50426299
PNG
(CHEMBL2312398)
Show SMILES CN(C)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-12(2)8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,3-5,11H2,1-2H3,(H,14,15)(H,16,17)/t6-,7+/s2
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5.39E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O
Show InChI InChI=1/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/s2
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5.78E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2


(Rattus norvegicus)
BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O
Show InChI InChI=1/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/s2
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8.05E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Rattus norvegicus)
BDBM50426294
PNG
(CHEMBL2312399)
Show SMILES CCN(CC)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C12H22N2O5/c1-3-14(4-2)10(15)6-5-8(11(16)17)7-9(13)12(18)19/h8-9H,3-7,13H2,1-2H3,(H,16,17)(H,18,19)/t8-,9+/s2
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8.65E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Rattus norvegicus)
BDBM50252052
PNG
((2S,4R)-2-amino-4-(3-(ethylamino)-3-oxopropyl)pent...)
Show SMILES CCNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-2-12-8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,2-5,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t6-,7+/s2
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1.06E+4n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat recombinant iGluR6


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Ionotropic glutamate receptor kainate 2/5


(Rattus norvegicus)
BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O
Show InChI InChI=1/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/s2
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1.42E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Rattus norvegicus)
BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O
Show InChI InChI=1/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/s2
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3.09E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2


(Rattus norvegicus)
BDBM50426299
PNG
(CHEMBL2312398)
Show SMILES CN(C)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-12(2)8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,3-5,11H2,1-2H3,(H,14,15)(H,16,17)/t6-,7+/s2
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4.92E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2


(Rattus norvegicus)
BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O
Show InChI InChI=1/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/s2
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7.11E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2


(Rattus norvegicus)
BDBM50426294
PNG
(CHEMBL2312399)
Show SMILES CCN(CC)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C12H22N2O5/c1-3-14(4-2)10(15)6-5-8(11(16)17)7-9(13)12(18)19/h8-9H,3-7,13H2,1-2H3,(H,16,17)(H,18,19)/t8-,9+/s2
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length recombinant rat GluKA2(R) receptor expressed in sf9 cells by liquid scintillation counting


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Rattus norvegicus)
BDBM50426299
PNG
(CHEMBL2312398)
Show SMILES CN(C)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-12(2)8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,3-5,11H2,1-2H3,(H,14,15)(H,16,17)/t6-,7+/s2
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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6.80E+5n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT2 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50252052
PNG
((2S,4R)-2-amino-4-(3-(ethylamino)-3-oxopropyl)pent...)
Show SMILES CCNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-2-12-8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,2-5,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t6-,7+/s2
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>1.00E+6n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]LY43915 from rat mGluR3 expressed in CHO cells by SPA


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3 (mGlu3)


(Rattus norvegicus (Rat))
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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>1.00E+6n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]LY43915 from rat mGluR3 expressed in CHO cells by SPA


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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>1.00E+6n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]LY43915 from rat mGluR2 expressed in CHO cells by SPA


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50252052
PNG
((2S,4R)-2-amino-4-(3-(ethylamino)-3-oxopropyl)pent...)
Show SMILES CCNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-2-12-8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,2-5,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t6-,7+/s2
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>1.00E+6n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]LY43915 from rat mGluR2 expressed in CHO cells by SPA


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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>3.00E+6n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at EAAT1 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O
Show InChI InChI=1/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/s2
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O
Show InChI InChI=1/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/s2
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O
Show InChI InChI=1/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/s2
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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n/an/a>1.00E+6n/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of glutamate-induced depolarization in human EAAT1 expressed in HEK293 cells by FMP assay


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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n/an/a 1.00E+6n/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of glutamate-induced depolarization in human human EAAT2 expressed in HEK293 cells by FMP assay


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50426294
PNG
(CHEMBL2312399)
Show SMILES CCN(CC)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C12H22N2O5/c1-3-14(4-2)10(15)6-5-8(11(16)17)7-9(13)12(18)19/h8-9H,3-7,13H2,1-2H3,(H,16,17)(H,18,19)/t8-,9+/s2
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O
Show InChI InChI=1/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/s2
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by [3H]-D-Asp uptake assay


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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n/an/an/an/a>1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu2 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assay


J Med Chem 59: 914-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01333
BindingDB Entry DOI: 10.7270/Q2000408
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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n/an/an/an/a>1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu5 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay


J Med Chem 59: 914-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01333
BindingDB Entry DOI: 10.7270/Q2000408
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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n/an/an/an/a>1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay


J Med Chem 59: 914-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01333
BindingDB Entry DOI: 10.7270/Q2000408
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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n/an/an/an/a>1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu4 receptor expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP production


J Med Chem 59: 914-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01333
BindingDB Entry DOI: 10.7270/Q2000408
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50252052
PNG
((2S,4R)-2-amino-4-(3-(ethylamino)-3-oxopropyl)pent...)
Show SMILES CCNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-2-12-8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,2-5,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t6-,7+/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Activity at rat mGluR1 expressed in HEK293 cells assessed as calcium mobilization by FLIPR


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Activity at rat mGluR1 expressed in HEK293 cells assessed as calcium mobilization by FLIPR


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50252052
PNG
((2S,4R)-2-amino-4-(3-(ethylamino)-3-oxopropyl)pent...)
Show SMILES CCNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-2-12-8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,2-5,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t6-,7+/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Activity at rat mGluR5 expressed in HEK293 cells assessed as calcium mobilization by FLIPR


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Activity at rat mGluR5 expressed in HEK293 cells assessed as calcium mobilization by FLIPR


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50252052
PNG
((2S,4R)-2-amino-4-(3-(ethylamino)-3-oxopropyl)pent...)
Show SMILES CCNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-2-12-8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,2-5,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t6-,7+/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Activity at rat mGluR2 expressed in CHO cells assessed as calcium mobilization by FLIPR


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Activity at rat mGluR2 expressed in CHO cells assessed as calcium mobilization by FLIPR


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50252052
PNG
((2S,4R)-2-amino-4-(3-(ethylamino)-3-oxopropyl)pent...)
Show SMILES CCNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-2-12-8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,2-5,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t6-,7+/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Activity at mGluR4 assessed as calcium mobilization by FLIPR


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Activity at mGluR4 assessed as calcium mobilization by FLIPR


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50426296
PNG
(CHEMBL2312396)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC#C)C(O)=O)C(O)=O
Show InChI InChI=1/C11H16N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h1,7-8H,3-6,12H2,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/s2
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50426293
PNG
(CHEMBL2312400)
Show SMILES N[C@@H](C[C@@H](CCC(=O)N1CCCCC1)C(O)=O)C(O)=O
Show InChI InChI=1/C13H22N2O5/c14-10(13(19)20)8-9(12(17)18)4-5-11(16)15-6-2-1-3-7-15/h9-10H,1-8,14H2,(H,17,18)(H,19,20)/t9-,10+/s2
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]-D-Asp uptake assay


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
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