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26 similar compounds to monomer 50306895

Compile data set for download or QSAR
Wt: 365.2
BDBM50254479
Wt: 379.2
BDBM50254614
Wt: 393.3
BDBM50254615
Wt: 379.2
BDBM50254616
Wt: 407.3
BDBM50254617
Wt: 435.3
BDBM50254618
Wt: 463.4
BDBM50254653
Wt: 413.3
BDBM50254655
Wt: 427.3
BDBM50254656
Wt: 363.2
BDBM50254696
Wt: 377.2
BDBM50254697
Wt: 391.2
BDBM50254698
Wt: 405.3
BDBM50254699
Wt: 421.3
BDBM50254778
Wt: 467.3
BDBM50254737
Displayed 1 to 15 (of 26 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50254479,50254614,50254615,50254616,50254617,50254618,50254653,50254655,50254656,50254696,50254697,50254698,50254699,50254778,50254737   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254479
PNG
(7-(3,4-dichlorophenyl)-5-methyl-N-propyl-4,7-dihyd...)
Show SMILES CCCNC(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1/C17H18Cl2N4O/c1-3-7-20-17(24)15-10(2)22-14-6-8-21-23(14)16(15)11-4-5-12(18)13(19)9-11/h4-6,8-9,15-16H,3,7H2,1-2H3,(H,20,24)
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n/an/a 490n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254778
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES COC[C@@H]1CCCN1C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1/C20H22Cl2N4O2/c1-12-18(20(27)25-9-3-4-14(25)11-28-2)19(26-17(24-12)7-8-23-26)13-5-6-15(21)16(22)10-13/h5-8,10,14,18-19H,3-4,9,11H2,1-2H3/t14-,18?,19?/s2
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Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254615
PNG
(7-(3,4-dichlorophenyl)-5-methyl-N-pentyl-4,7-dihyd...)
Show SMILES CCCCCNC(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1/C19H22Cl2N4O/c1-3-4-5-9-22-19(26)17-12(2)24-16-8-10-23-25(16)18(17)13-6-7-14(20)15(21)11-13/h6-8,10-11,17-18H,3-5,9H2,1-2H3,(H,22,26)
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n/an/a 590n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254616
PNG
(7-(3,4-dichlorophenyl)-N,N-diethyl-5-methyl-4,7-di...)
Show SMILES CCN(CC)C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1/C18H20Cl2N4O/c1-4-23(5-2)18(25)16-11(3)22-15-8-9-21-24(15)17(16)12-6-7-13(19)14(20)10-12/h6-10,16-17H,4-5H2,1-3H3
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n/an/a 440n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254617
PNG
(7-(3,4-dichlorophenyl)-5-methyl-N,N-dipropyl-4,7-d...)
Show SMILES CCCN(CCC)C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1/C20H24Cl2N4O/c1-4-10-25(11-5-2)20(27)18-13(3)24-17-8-9-23-26(17)19(18)14-6-7-15(21)16(22)12-14/h6-9,12,18-19H,4-5,10-11H2,1-3H3
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254618
PNG
(CHEMBL520917 | N,N-dibutyl-7-(3,4-dichlorophenyl)-...)
Show SMILES CCCCN(CCCC)C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1/C22H28Cl2N4O/c1-4-6-12-27(13-7-5-2)22(29)20-15(3)26-19-10-11-25-28(19)21(20)16-8-9-17(23)18(24)14-16/h8-11,14,20-21H,4-7,12-13H2,1-3H3
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n/an/a 310n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254653
PNG
(7-(3,4-dichlorophenyl)-5-methyl-N,N-dipentyl-4,7-d...)
Show SMILES CCCCCN(CCCCC)C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1/C24H32Cl2N4O/c1-4-6-8-14-29(15-9-7-5-2)24(31)22-17(3)28-21-12-13-27-30(21)23(22)18-10-11-19(25)20(26)16-18/h10-13,16,22-23H,4-9,14-15H2,1-3H3
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Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254655
PNG
(CHEMBL465086 | N-benzyl-7-(3,4-dichlorophenyl)-5-m...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)NCc1ccccc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C21H18Cl2N4O/c1-13-19(21(28)24-12-14-5-3-2-4-6-14)20(27-18(26-13)9-10-25-27)15-7-8-16(22)17(23)11-15/h2-11,19-20H,12H2,1H3,(H,24,28)
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n/an/a 160n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254656
PNG
(7-(3,4-dichlorophenyl)-5-methyl-N-phenethyl-4,7-di...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)NCCc1ccccc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C22H20Cl2N4O/c1-14-20(22(29)25-11-9-15-5-3-2-4-6-15)21(28-19(27-14)10-12-26-28)16-7-8-17(23)18(24)13-16/h2-8,10,12-13,20-21H,9,11H2,1H3,(H,25,29)
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n/an/a 100n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254696
PNG
(CHEMBL518717 | azetidin-1-yl(7-(3,4-dichlorophenyl...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C17H16Cl2N4O/c1-10-15(17(24)22-7-2-8-22)16(23-14(21-10)5-6-20-23)11-3-4-12(18)13(19)9-11/h3-6,9,15-16H,2,7-8H2,1H3
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n/an/a 970n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254697
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C18H18Cl2N4O/c1-11-16(18(25)23-8-2-3-9-23)17(24-15(22-11)6-7-21-24)12-4-5-13(19)14(20)10-12/h4-7,10,16-17H,2-3,8-9H2,1H3
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n/an/a 660n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254698
PNG
(5-(1-cyclohexylvinyl)-4-(3,4-dimethylphenyl)-6-met...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C19H20Cl2N4O/c1-12-17(19(26)24-9-3-2-4-10-24)18(25-16(23-12)7-8-22-25)13-5-6-14(20)15(21)11-13/h5-8,11,17-18H,2-4,9-10H2,1H3
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n/an/a 90n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254699
PNG
(CHEMBL518718 | azepan-1-yl(7-(3,4-dichlorophenyl)-...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C20H22Cl2N4O/c1-13-18(20(27)25-10-4-2-3-5-11-25)19(26-17(24-13)8-9-23-26)14-6-7-15(21)16(22)12-14/h6-9,12,18-19H,2-5,10-11H2,1H3
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n/an/a 190n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254737
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCC(CC1)c1ccccc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C25H24Cl2N4O/c1-16-23(25(32)30-13-10-18(11-14-30)17-5-3-2-4-6-17)24(31-22(29-16)9-12-28-31)19-7-8-20(26)21(27)15-19/h2-9,12,15,18,23-24H,10-11,13-14H2,1H3
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n/an/a 159n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254778
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES COC[C@@H]1CCCN1C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1/C20H22Cl2N4O2/c1-12-18(20(27)25-9-3-4-14(25)11-28-2)19(26-17(24-12)7-8-23-26)13-5-6-15(21)16(22)10-13/h5-8,10,14,18-19H,3-4,9,11H2,1-2H3/t14-,18?,19?/s2
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n/an/a 200n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254617
PNG
(7-(3,4-dichlorophenyl)-5-methyl-N,N-dipropyl-4,7-d...)
Show SMILES CCCN(CCC)C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1/C20H24Cl2N4O/c1-4-10-25(11-5-2)20(27)18-13(3)24-17-8-9-23-26(17)19(18)14-6-7-15(21)16(22)12-14/h6-9,12,18-19H,4-5,10-11H2,1-3H3
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n/an/a 70n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Bioorg Med Chem Lett 19: 5469-73 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.083
BindingDB Entry DOI: 10.7270/Q24M94M6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254697
PNG
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C18H18Cl2N4O/c1-11-16(18(25)23-8-2-3-9-23)17(24-15(22-11)6-7-21-24)12-4-5-13(19)14(20)10-12/h4-7,10,16-17H,2-3,8-9H2,1H3
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n/an/a 660n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells


Bioorg Med Chem Lett 20: 1436-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.085
BindingDB Entry DOI: 10.7270/Q2MG7PM1
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50254614
PNG
(CHEMBL481396 | N-butyl-7-(3,4-dichlorophenyl)-5-me...)
Show SMILES CCCCNC(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C
Show InChI InChI=1/C18H20Cl2N4O/c1-3-4-8-21-18(25)16-11(2)23-15-7-9-22-24(15)17(16)12-5-6-13(19)14(20)10-12/h5-7,9-10,16-17H,3-4,8H2,1-2H3,(H,21,25)
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n/an/a 440n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique


Bioorg Med Chem Lett 18: 6381-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7
More data for this
Ligand-Target Pair