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27 similar compounds to monomer 50255372

Compile data set for download or QSAR
Wt: 341.3
BDBM50255145
Wt: 359.3
BDBM50255371
Wt: 371.8
BDBM50255374
Wt: 392.2
BDBM50255375
Wt: 375.7
BDBM50255098
Wt: 359.3
BDBM50255418
Wt: 355.3
BDBM50255419
Wt: 375.7
BDBM50255420
Wt: 359.3
BDBM50255421
Wt: 375.7
BDBM50255463
Wt: 392.2
BDBM50255464
Wt: 359.3
BDBM50255465
Wt: 355.3
BDBM50255466
Wt: 392.2
BDBM50255513
Wt: 432.8
BDBM50255514
Displayed 1 to 15 (of 27 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50255145,50255371,50255374,50255375,50255098,50255418,50255419,50255420,50255421,50255463,50255464,50255465,50255466,50255513,50255514   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255375
PNG
(4-(2,3-dichlorophenylamino)-6,7-dimethoxyquinoline...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3cccc(Cl)c3Cl)c2cc1OC
Show InChI InChI=1S/C18H15Cl2N3O3/c1-25-14-6-9-13(7-15(14)26-2)22-8-10(18(21)24)17(9)23-12-5-3-4-11(19)16(12)20/h3-8H,1-2H3,(H2,21,24)(H,22,23)
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n/an/a 6n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255418
PNG
(4-(2,4-difluorophenylamino)-6,7-dimethoxyquinoline...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3ccc(F)cc3F)c2cc1OC
Show InChI InChI=1S/C18H15F2N3O3/c1-25-15-6-10-14(7-16(15)26-2)22-8-11(18(21)24)17(10)23-13-4-3-9(19)5-12(13)20/h3-8H,1-2H3,(H2,21,24)(H,22,23)
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n/an/a 25n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of CSF1R (unknown origin)


Bioorg Med Chem Lett 19: 701-5 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.044
BindingDB Entry DOI: 10.7270/Q2JW8DSV
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255464
PNG
(4-(3,4-dichlorophenylamino)-6,7-dimethoxyquinoline...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3ccc(Cl)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C18H15Cl2N3O3/c1-25-15-6-10-14(7-16(15)26-2)22-8-11(18(21)24)17(10)23-9-3-4-12(19)13(20)5-9/h3-8H,1-2H3,(H2,21,24)(H,22,23)
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n/an/a 9n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255419
PNG
(4-(2-fluoro-4-methylphenylamino)-6,7-dimethoxyquin...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3ccc(C)cc3F)c2cc1OC
Show InChI InChI=1S/C19H18FN3O3/c1-10-4-5-14(13(20)6-10)23-18-11-7-16(25-2)17(26-3)8-15(11)22-9-12(18)19(21)24/h4-9H,1-3H3,(H2,21,24)(H,22,23)
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n/an/a 10n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255514
PNG
(4-(3-chloro-4-fluorophenylamino)-7-(2-(dimethylami...)
Show SMILES COc1cc2c(Nc3ccc(F)c(Cl)c3)c(cnc2cc1OCCN(C)C)C(N)=O
Show InChI InChI=1S/C21H22ClFN4O3/c1-27(2)6-7-30-19-10-17-13(9-18(19)29-3)20(14(11-25-17)21(24)28)26-12-4-5-16(23)15(22)8-12/h4-5,8-11H,6-7H2,1-3H3,(H2,24,28)(H,25,26)
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n/an/a 12n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255466
PNG
(4-(2-fluoro-5-methylphenylamino)-6,7-dimethoxyquin...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3cc(C)ccc3F)c2cc1OC
Show InChI InChI=1S/C19H18FN3O3/c1-10-4-5-13(20)15(6-10)23-18-11-7-16(25-2)17(26-3)8-14(11)22-9-12(18)19(21)24/h4-9H,1-3H3,(H2,21,24)(H,22,23)
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n/an/a 13n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255465
PNG
(4-(2,5-difluorophenylamino)-6,7-dimethoxyquinoline...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3cc(F)ccc3F)c2cc1OC
Show InChI InChI=1S/C18H15F2N3O3/c1-25-15-6-10-13(7-16(15)26-2)22-8-11(18(21)24)17(10)23-14-5-9(19)3-4-12(14)20/h3-8H,1-2H3,(H2,21,24)(H,22,23)
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n/an/a 15n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255463
PNG
(4-(3-chloro-4-fluorophenylamino)-6,7-dimethoxyquin...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C18H15ClFN3O3/c1-25-15-6-10-14(7-16(15)26-2)22-8-11(18(21)24)17(10)23-9-3-4-13(20)12(19)5-9/h3-8H,1-2H3,(H2,21,24)(H,22,23)
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n/an/a 16n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255420
PNG
(4-(4-chloro-2-fluorophenylamino)-6,7-dimethoxyquin...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3ccc(Cl)cc3F)c2cc1OC
Show InChI InChI=1S/C18H15ClFN3O3/c1-25-15-6-10-14(7-16(15)26-2)22-8-11(18(21)24)17(10)23-13-4-3-9(19)5-12(13)20/h3-8H,1-2H3,(H2,21,24)(H,22,23)
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n/an/a 18n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255513
PNG
(4-(3,5-dichlorophenylamino)-6,7-dimethoxyquinoline...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3cc(Cl)cc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C18H15Cl2N3O3/c1-25-15-6-12-14(7-16(15)26-2)22-8-13(18(21)24)17(12)23-11-4-9(19)3-10(20)5-11/h3-8H,1-2H3,(H2,21,24)(H,22,23)
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n/an/a 22n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255418
PNG
(4-(2,4-difluorophenylamino)-6,7-dimethoxyquinoline...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3ccc(F)cc3F)c2cc1OC
Show InChI InChI=1S/C18H15F2N3O3/c1-25-15-6-10-14(7-16(15)26-2)22-8-11(18(21)24)17(10)23-13-4-3-9(19)5-12(13)20/h3-8H,1-2H3,(H2,21,24)(H,22,23)
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n/an/a 25n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255371
PNG
(4-(2,3-difluorophenylamino)-6,7-dimethoxyquinoline...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3cccc(F)c3F)c2cc1OC
Show InChI InChI=1S/C18H15F2N3O3/c1-25-14-6-9-13(7-15(14)26-2)22-8-10(18(21)24)17(9)23-12-5-3-4-11(19)16(12)20/h3-8H,1-2H3,(H2,21,24)(H,22,23)
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n/an/a 26n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255421
PNG
(4-(3,4-difluorophenylamino)-6,7-dimethoxyquinoline...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3ccc(F)c(F)c3)c2cc1OC
Show InChI InChI=1S/C18H15F2N3O3/c1-25-15-6-10-14(7-16(15)26-2)22-8-11(18(21)24)17(10)23-9-3-4-12(19)13(20)5-9/h3-8H,1-2H3,(H2,21,24)(H,22,23)
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n/an/a 28n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255374
PNG
(4-(3-chloro-2-methylphenylamino)-6,7-dimethoxyquin...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3cccc(Cl)c3C)c2cc1OC
Show InChI InChI=1S/C19H18ClN3O3/c1-10-13(20)5-4-6-14(10)23-18-11-7-16(25-2)17(26-3)8-15(11)22-9-12(18)19(21)24/h4-9H,1-3H3,(H2,21,24)(H,22,23)
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n/an/a 29n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255098
PNG
(4-(2-chloro-4-fluorophenylamino)-6,7-dimethoxyquin...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3ccc(F)cc3Cl)c2cc1OC
Show InChI InChI=1S/C18H15ClFN3O3/c1-25-15-6-10-14(7-16(15)26-2)22-8-11(18(21)24)17(10)23-13-4-3-9(20)5-12(13)19/h3-8H,1-2H3,(H2,21,24)(H,22,23)
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n/an/a 200n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50255145
PNG
(4-(2-fluorophenylamino)-6,7-dimethoxyquinoline-3-c...)
Show SMILES COc1cc2ncc(C(N)=O)c(Nc3ccccc3F)c2cc1OC
Show InChI InChI=1S/C18H16FN3O3/c1-24-15-7-10-14(8-16(15)25-2)21-9-11(18(20)23)17(10)22-13-6-4-3-5-12(13)19/h3-9H,1-2H3,(H2,20,23)(H,21,22)
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n/an/a 9n/an/an/an/an/an/a



AstraZeneca R&D Boston

Curated by ChEMBL


Assay Description
Inhibition of His-tagged CSF1R catalytic domain (unknown origin) expressed in baculovirus by HTRF assay


Bioorg Med Chem Lett 19: 697-700 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.046
BindingDB Entry DOI: 10.7270/Q26M36P8
More data for this
Ligand-Target Pair