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19 similar compounds to monomer 50263455

Wt: 383.4
BDBM50263332
Wt: 383.4
BDBM50263333
Wt: 387.4
BDBM50263334
Wt: 423.3
BDBM50263335
Wt: 411.4
BDBM50263454
Wt: 399.4
BDBM50263456
Wt: 413.4
BDBM50263457
Wt: 347.2
BDBM50263959
Wt: 347.2
BDBM50263961
Wt: 398.4
BDBM50263362
Wt: 355.3
BDBM50264077
Wt: 361.4
BDBM50264078
Wt: 369.4
BDBM50264079
Wt: 369.4
BDBM50264080
Wt: 383.4
BDBM50264081
Displayed 1 to 15 (of 19 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50263332,50263333,50263334,50263335,50263454,50263456,50263457,50263959,50263961,50263362,50264077,50264078,50264079,50264080,50264081   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50264081
PNG
(9-(2,6-dimethylphenyl)-2-hydroxy-6,11-dihydro-5H-b...)
Show SMILES Cc1cccc(C)c1-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C25H21NO3/c1-13-4-3-5-14(2)23(13)16-7-8-17-18-9-6-15-10-20(25(28)29)22(27)12-19(15)24(18)26-21(17)11-16/h3-5,7-8,10-12,26-27H,6,9H2,1-2H3,(H,28,29)
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n/an/an/an/a 232n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50264080
PNG
(2-hydroxy-9-p-tolyl-6,11-dihydro-5H-benzo[a]carbaz...)
Show SMILES Cc1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C24H19NO3/c1-13-2-4-14(5-3-13)15-6-8-17-18-9-7-16-10-20(24(27)28)22(26)12-19(16)23(18)25-21(17)11-15/h2-6,8,10-12,25-26H,7,9H2,1H3,(H,27,28)
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n/an/an/an/a 109n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263333
PNG
(9-(3,5-dimethylphenyl)-2-hydroxy-6,11-dihydro-5H-b...)
Show SMILES Cc1cc(C)cc(c1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C25H21NO3/c1-13-7-14(2)9-17(8-13)15-3-5-18-19-6-4-16-10-21(25(28)29)23(27)12-20(16)24(19)26-22(18)11-15/h3,5,7-12,26-27H,4,6H2,1-2H3,(H,28,29)
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n/an/an/an/a 67n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263334
PNG
(9-(4-fluoro-3-methylphenyl)-2-hydroxy-6,11-dihydro...)
Show SMILES Cc1cc(ccc1F)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C24H18FNO3/c1-12-8-13(4-7-20(12)25)14-2-5-16-17-6-3-15-9-19(24(28)29)22(27)11-18(15)23(17)26-21(16)10-14/h2,4-5,7-11,26-27H,3,6H2,1H3,(H,28,29)
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n/an/an/an/a 35n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263335
PNG
(2-hydroxy-9-(3-(trifluoromethyl)phenyl)-6,11-dihyd...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4cc(ccc34)-c3cccc(c3)C(F)(F)F)-c2cc1O
Show InChI InChI=1S/C24H16F3NO3/c25-24(26,27)15-3-1-2-12(8-15)13-4-6-16-17-7-5-14-9-19(23(30)31)21(29)11-18(14)22(17)28-20(16)10-13/h1-4,6,8-11,28-29H,5,7H2,(H,30,31)
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n/an/an/an/a 148n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263362
PNG
(9-(4-(dimethylamino)phenyl)-2-hydroxy-6,11-dihydro...)
Show SMILES CN(C)c1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C25H22N2O3/c1-27(2)17-7-3-14(4-8-17)15-5-9-18-19-10-6-16-11-21(25(29)30)23(28)13-20(16)24(19)26-22(18)12-15/h3-5,7-9,11-13,26,28H,6,10H2,1-2H3,(H,29,30)
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n/an/an/an/a 284n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263454
PNG
(9-(4-butylphenyl)-2-hydroxy-6,11-dihydro-5H-benzo[...)
Show SMILES CCCCc1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C27H25NO3/c1-2-3-4-16-5-7-17(8-6-16)18-9-11-20-21-12-10-19-13-23(27(30)31)25(29)15-22(19)26(21)28-24(20)14-18/h5-9,11,13-15,28-29H,2-4,10,12H2,1H3,(H,30,31)
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n/an/an/an/a 26n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263456
PNG
(2-hydroxy-9-(4-(methoxymethyl)phenyl)-6,11-dihydro...)
Show SMILES COCc1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C25H21NO4/c1-30-13-14-2-4-15(5-3-14)16-6-8-18-19-9-7-17-10-21(25(28)29)23(27)12-20(17)24(19)26-22(18)11-16/h2-6,8,10-12,26-27H,7,9,13H2,1H3,(H,28,29)
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n/an/an/an/a 452n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263457
PNG
(2-hydroxy-9-(3-propoxyphenyl)-6,11-dihydro-5H-benz...)
Show SMILES CCCOc1cccc(c1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C26H23NO4/c1-2-10-31-18-5-3-4-15(11-18)16-6-8-19-20-9-7-17-12-22(26(29)30)24(28)14-21(17)25(20)27-23(19)13-16/h3-6,8,11-14,27-28H,2,7,9-10H2,1H3,(H,29,30)
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n/an/an/an/a 43n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263959
PNG
(2-hydroxy-9-(trifluoromethyl)-6,11-dihydro-5H-benz...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4cc(ccc34)C(F)(F)F)-c2cc1O
Show InChI InChI=1S/C18H12F3NO3/c19-18(20,21)9-2-4-10-11-3-1-8-5-13(17(24)25)15(23)7-12(8)16(11)22-14(10)6-9/h2,4-7,22-23H,1,3H2,(H,24,25)
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n/an/an/an/a 473n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263961
PNG
(2-hydroxy-8-(trifluoromethyl)-6,11-dihydro-5H-benz...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4ccc(cc34)C(F)(F)F)-c2cc1O
Show InChI InChI=1S/C18H12F3NO3/c19-18(20,21)9-2-4-14-12(6-9)10-3-1-8-5-13(17(24)25)15(23)7-11(8)16(10)22-14/h2,4-7,22-23H,1,3H2,(H,24,25)
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n/an/an/an/a 333n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50264077
PNG
(2-hydroxy-9-phenyl-6,11-dihydro-5H-benzo[a]carbazo...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4cc(ccc34)-c3ccccc3)-c2cc1O
Show InChI InChI=1S/C23H17NO3/c25-21-12-18-15(10-19(21)23(26)27)7-9-17-16-8-6-14(11-20(16)24-22(17)18)13-4-2-1-3-5-13/h1-6,8,10-12,24-25H,7,9H2,(H,26,27)
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n/an/an/an/a 373n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50264078
PNG
(9-cyclohexyl-2-hydroxy-6,11-dihydro-5H-benzo[a]car...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4cc(ccc34)C3CCCCC3)-c2cc1O
Show InChI InChI=1S/C23H23NO3/c25-21-12-18-15(10-19(21)23(26)27)7-9-17-16-8-6-14(11-20(16)24-22(17)18)13-4-2-1-3-5-13/h6,8,10-13,24-25H,1-5,7,9H2,(H,26,27)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50264079
PNG
(2-hydroxy-9-m-tolyl-6,11-dihydro-5H-benzo[a]carbaz...)
Show SMILES Cc1cccc(c1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C24H19NO3/c1-13-3-2-4-14(9-13)15-5-7-17-18-8-6-16-10-20(24(27)28)22(26)12-19(16)23(18)25-21(17)11-15/h2-5,7,9-12,25-26H,6,8H2,1H3,(H,27,28)
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n/an/an/an/a 194n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263332
PNG
(9-(3,4-dimethylphenyl)-2-hydroxy-6,11-dihydro-5H-b...)
Show SMILES Cc1ccc(cc1C)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C25H21NO3/c1-13-3-4-15(9-14(13)2)16-5-7-18-19-8-6-17-10-21(25(28)29)23(27)12-20(17)24(19)26-22(18)11-16/h3-5,7,9-12,26-27H,6,8H2,1-2H3,(H,28,29)
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n/an/an/an/a 65n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair