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98 similar compounds to monomer 50270264

Compile data set for download or QSAR
Wt: 1396.6
BDBM50269882
Wt: 1423.6
BDBM50269886
Wt: 1380.6
BDBM50269892
Wt: 1410.6
BDBM50269913
Wt: 1437.7
BDBM50270057
Wt: 1553.8
BDBM50270060
Wt: 1324.5
BDBM50270084
Wt: 1239.4
BDBM50270093
Wt: 1239.4
BDBM50270094
Wt: 1154.3
BDBM50270101
Wt: 1296.5
BDBM50270105
Wt: 1296.5
BDBM50270106
Wt: 1211.4
BDBM50270115
Wt: 1253.5
BDBM50270127
Wt: 1395.6
BDBM50270133
Displayed 1 to 15 (of 98 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50269882,50269886,50269892,50269913,50270057,50270060,50270084,50270093,50270094,50270101,50270105,50270106,50270115,50270127,50270133   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50270060
PNG
(CHEMBL455792 | TPQRARRRKKRT)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1/C63H120N30O16/c1-32(83-48(98)37(16-8-26-78-59(68)69)87-54(104)42(22-23-44(66)96)91-56(106)43-21-13-31-93(43)57(107)45(67)33(2)94)47(97)84-38(17-9-27-79-60(70)71)51(101)88-40(19-11-29-81-62(74)75)53(103)89-39(18-10-28-80-61(72)73)52(102)86-35(14-4-6-24-64)49(99)85-36(15-5-7-25-65)50(100)90-41(20-12-30-82-63(76)77)55(105)92-46(34(3)95)58(108)109/h32-43,45-46,94-95H,4-31,64-65,67H2,1-3H3,(H2,66,96)(H,83,98)(H,84,97)(H,85,99)(H,86,102)(H,87,104)(H,88,101)(H,89,103)(H,90,100)(H,91,106)(H,92,105)(H,108,109)(H4,68,69,78)(H4,70,71,79)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)/t32-,33+,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,45-,46-/s2
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33n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50270057
PNG
(CHEMBL526181 | TPRARRRKKRN)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O
Show InChI InChI=1/C58H112N30O13/c1-30(79-45(93)34(15-7-23-74-54(64)65)86-52(100)40-20-12-28-88(40)53(101)42(62)31(2)89)44(92)80-35(16-8-24-75-55(66)67)48(96)83-37(18-10-26-77-57(70)71)50(98)84-36(17-9-25-76-56(68)69)49(97)82-32(13-3-5-21-59)46(94)81-33(14-4-6-22-60)47(95)85-38(19-11-27-78-58(72)73)51(99)87-39(43(63)91)29-41(61)90/h30-40,42,89H,3-29,59-60,62H2,1-2H3,(H2,61,90)(H2,63,91)(H,79,93)(H,80,92)(H,81,94)(H,82,97)(H,83,96)(H,84,98)(H,85,95)(H,86,100)(H,87,99)(H4,64,65,74)(H4,66,67,75)(H4,68,69,76)(H4,70,71,77)(H4,72,73,78)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,42-/s2
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45n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50269882
PNG
(CHEMBL526190 | TPRSRRRKKRG)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O
Show InChI InChI=1/C56H109N29O13/c1-30(87)41(60)51(98)85-27-11-19-39(85)50(97)83-37(18-10-26-75-56(69)70)48(95)84-38(29-86)49(96)82-36(17-9-25-74-55(67)68)47(94)81-35(16-8-24-73-54(65)66)46(93)80-34(15-7-23-72-53(63)64)45(92)79-33(13-3-5-21-58)44(91)78-32(12-2-4-20-57)43(90)77-31(14-6-22-71-52(61)62)42(89)76-28-40(59)88/h30-39,41,86-87H,2-29,57-58,60H2,1H3,(H2,59,88)(H,76,89)(H,77,90)(H,78,91)(H,79,92)(H,80,93)(H,81,94)(H,82,96)(H,83,97)(H,84,95)(H4,61,62,71)(H4,63,64,72)(H4,65,66,73)(H4,67,68,74)(H4,69,70,75)/t30-,31+,32+,33+,34+,35+,36+,37+,38+,39+,41+/s2
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>100n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50269886
PNG
(CHEMBL526491 | TPRNRRRKKRG)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O
Show InChI InChI=1/C57H110N30O13/c1-30(88)42(62)52(100)87-27-11-19-39(87)51(99)85-37(18-10-26-77-57(71)72)49(97)86-38(28-40(60)89)50(98)84-36(17-9-25-76-56(69)70)48(96)83-35(16-8-24-75-55(67)68)47(95)82-34(15-7-23-74-54(65)66)46(94)81-33(13-3-5-21-59)45(93)80-32(12-2-4-20-58)44(92)79-31(14-6-22-73-53(63)64)43(91)78-29-41(61)90/h30-39,42,88H,2-29,58-59,62H2,1H3,(H2,60,89)(H2,61,90)(H,78,91)(H,79,92)(H,80,93)(H,81,94)(H,82,95)(H,83,96)(H,84,98)(H,85,99)(H,86,97)(H4,63,64,73)(H4,65,66,74)(H4,67,68,75)(H4,69,70,76)(H4,71,72,77)/t30-,31+,32+,33+,34+,35+,36+,37+,38+,39+,42+/s2
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>100n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50269913
PNG
(CHEMBL525570 | TPRARRRKKRS)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1/C57H111N29O13/c1-30(77-44(91)34(15-7-23-72-53(62)63)84-51(98)40-20-12-28-86(40)52(99)41(60)31(2)88)43(90)78-35(16-8-24-73-54(64)65)47(94)81-37(18-10-26-75-56(68)69)49(96)82-36(17-9-25-74-55(66)67)48(95)80-32(13-3-5-21-58)45(92)79-33(14-4-6-22-59)46(93)83-38(19-11-27-76-57(70)71)50(97)85-39(29-87)42(61)89/h30-41,87-88H,3-29,58-60H2,1-2H3,(H2,61,89)(H,77,91)(H,78,90)(H,79,92)(H,80,95)(H,81,94)(H,82,96)(H,83,93)(H,84,98)(H,85,97)(H4,62,63,72)(H4,64,65,73)(H4,66,67,74)(H4,68,69,75)(H4,70,71,76)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-/s2
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>100n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50269892
PNG
(CHEMBL508995 | TPR1RRRKKRG)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O
Show InChI InChI=1/C56H109N29O12/c1-31(86)42(60)51(97)85-29-11-19-39(85)50(96)84-32(14-6-23-72-52(61)62)43(89)71-28-20-41(88)78-34(16-8-25-74-54(65)66)45(91)82-37(17-9-26-75-55(67)68)49(95)83-38(18-10-27-76-56(69)70)48(94)81-36(13-3-5-22-58)47(93)80-35(12-2-4-21-57)46(92)79-33(15-7-24-73-53(63)64)44(90)77-30-40(59)87/h31-39,42,86H,2-30,57-58,60H2,1H3,(H2,59,87)(H,71,89)(H,77,90)(H,78,88)(H,79,92)(H,80,93)(H,81,94)(H,82,91)(H,83,95)(H,84,96)(H4,61,62,72)(H4,63,64,73)(H4,65,66,74)(H4,67,68,75)(H4,69,70,76)/t31-,32+,33+,34+,35+,36+,37+,38+,39+,42+/s2
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>100n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50270105
PNG
(CHEMBL508462 | TPAARRRKKRG)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(O)=O
Show InChI InChI=1/C53H101N25O13/c1-28(71-48(90)37-19-12-26-78(37)49(91)39(56)30(3)79)40(82)70-29(2)41(83)72-34(16-9-23-66-51(59)60)45(87)76-36(18-11-25-68-53(63)64)47(89)77-35(17-10-24-67-52(61)62)46(88)75-33(14-5-7-21-55)44(86)74-32(13-4-6-20-54)43(85)73-31(15-8-22-65-50(57)58)42(84)69-27-38(80)81/h28-37,39,79H,4-27,54-56H2,1-3H3,(H,69,84)(H,70,82)(H,71,90)(H,72,83)(H,73,85)(H,74,86)(H,75,88)(H,76,87)(H,77,89)(H,80,81)(H4,57,58,65)(H4,59,60,66)(H4,61,62,67)(H4,63,64,68)/t28-,29-,30+,31-,32-,33-,34-,35-,36-,37-,39-/s2
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>100n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50270106
PNG
(CHEMBL509545 | TPRAARRKKRG)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(O)=O
Show InChI InChI=1/C53H101N25O13/c1-28(71-43(85)34(16-9-23-66-51(59)60)77-48(90)37-19-12-26-78(37)49(91)39(56)30(3)79)40(82)70-29(2)41(83)72-35(17-10-24-67-52(61)62)46(88)76-36(18-11-25-68-53(63)64)47(89)75-33(14-5-7-21-55)45(87)74-32(13-4-6-20-54)44(86)73-31(15-8-22-65-50(57)58)42(84)69-27-38(80)81/h28-37,39,79H,4-27,54-56H2,1-3H3,(H,69,84)(H,70,82)(H,71,85)(H,72,83)(H,73,86)(H,74,87)(H,75,89)(H,76,88)(H,77,90)(H,80,81)(H4,57,58,65)(H4,59,60,66)(H4,61,62,67)(H4,63,64,68)/t28-,29-,30+,31-,32-,33-,34-,35-,36-,37-,39-/s2
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>100n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50270115
PNG
(CHEMBL500226 | TPAAARRKKRG)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(O)=O
Show InChI InChI=1/C50H94N22O13/c1-26(64-39(77)27(2)66-46(84)35-18-12-24-72(35)47(85)37(53)29(4)73)38(76)65-28(3)40(78)67-33(16-10-22-61-49(56)57)44(82)71-34(17-11-23-62-50(58)59)45(83)70-32(14-6-8-20-52)43(81)69-31(13-5-7-19-51)42(80)68-30(15-9-21-60-48(54)55)41(79)63-25-36(74)75/h26-35,37,73H,5-25,51-53H2,1-4H3,(H,63,79)(H,64,77)(H,65,76)(H,66,84)(H,67,78)(H,68,80)(H,69,81)(H,70,83)(H,71,82)(H,74,75)(H4,54,55,60)(H4,56,57,61)(H4,58,59,62)/t26-,27-,28-,29+,30-,31-,32-,33-,34-,35-,37-/s2
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>100n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50270127
PNG
(CHEMBL503495 | TPAAARRKKRV)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(O)=O
Show InChI InChI=1/C53H100N22O13/c1-27(2)39(50(87)88)74-47(84)36(19-13-25-65-53(61)62)73-44(81)33(16-8-10-22-55)70-43(80)32(15-7-9-21-54)71-46(83)35(18-12-24-64-52(59)60)72-45(82)34(17-11-23-63-51(57)58)69-42(79)30(5)67-40(77)28(3)66-41(78)29(4)68-48(85)37-20-14-26-75(37)49(86)38(56)31(6)76/h27-39,76H,7-26,54-56H2,1-6H3,(H,66,78)(H,67,77)(H,68,85)(H,69,79)(H,70,80)(H,71,83)(H,72,82)(H,73,81)(H,74,84)(H,87,88)(H4,57,58,63)(H4,59,60,64)(H4,61,62,65)/t28-,29-,30-,31+,32-,33-,34-,35-,36-,37-,38-,39-/s2
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>100n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50270101
PNG
(CHEMBL504714 | TPAAARRKKR)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1/C48H91N21O12/c1-25(61-37(72)26(2)63-43(78)34-18-12-24-69(34)44(79)35(51)28(4)70)36(71)62-27(3)38(73)64-31(15-9-21-58-46(52)53)40(75)67-32(16-10-22-59-47(54)55)41(76)65-29(13-5-7-19-49)39(74)66-30(14-6-8-20-50)42(77)68-33(45(80)81)17-11-23-60-48(56)57/h25-35,70H,5-24,49-51H2,1-4H3,(H,61,72)(H,62,71)(H,63,78)(H,64,73)(H,65,76)(H,66,74)(H,67,75)(H,68,77)(H,80,81)(H4,52,53,58)(H4,54,55,59)(H4,56,57,60)/t25-,26-,27-,28+,29-,30-,31-,32-,33-,34-,35-/s2
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>100n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50270094
PNG
(CHEMBL526689 | TPRAARRKKR)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1/C51H98N24O12/c1-27(68-40(79)32(15-8-22-63-48(55)56)73-45(84)36-19-12-26-75(36)46(85)37(54)29(3)76)38(77)67-28(2)39(78)69-33(16-9-23-64-49(57)58)42(81)72-34(17-10-24-65-50(59)60)43(82)70-30(13-4-6-20-52)41(80)71-31(14-5-7-21-53)44(83)74-35(47(86)87)18-11-25-66-51(61)62/h27-37,76H,4-26,52-54H2,1-3H3,(H,67,77)(H,68,79)(H,69,78)(H,70,82)(H,71,80)(H,72,81)(H,73,84)(H,74,83)(H,86,87)(H4,55,56,63)(H4,57,58,64)(H4,59,60,65)(H4,61,62,66)/t27-,28-,29+,30-,31-,32-,33-,34-,35-,36-,37-/s2
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>100n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50270093
PNG
(CHEMBL503701 | TPAARRRKKR)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1/C51H98N24O12/c1-27(68-45(84)36-19-12-26-75(36)46(85)37(54)29(3)76)38(77)67-28(2)39(78)69-32(15-8-22-63-48(55)56)41(80)72-34(17-10-24-65-50(59)60)43(82)73-33(16-9-23-64-49(57)58)42(81)70-30(13-4-6-20-52)40(79)71-31(14-5-7-21-53)44(83)74-35(47(86)87)18-11-25-66-51(61)62/h27-37,76H,4-26,52-54H2,1-3H3,(H,67,77)(H,68,84)(H,69,78)(H,70,81)(H,71,79)(H,72,80)(H,73,82)(H,74,83)(H,86,87)(H4,55,56,63)(H4,57,58,64)(H4,59,60,65)(H4,61,62,66)/t27-,28-,29+,30-,31-,32-,33-,34-,35-,36-,37-/s2
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>100n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50270133
PNG
(CHEMBL498821 | TPRARRRKKRs)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N(C)CC(O)=O
Show InChI InChI=1/C57H110N28O13/c1-31(76-44(90)35(16-8-24-71-53(61)62)82-50(96)40-21-13-29-85(40)52(98)42(60)32(2)86)43(89)77-36(17-9-25-72-54(63)64)46(92)80-38(19-11-27-74-56(67)68)48(94)81-37(18-10-26-73-55(65)66)47(93)78-33(14-4-6-22-58)45(91)79-34(15-5-7-23-59)49(95)83-39(20-12-28-75-57(69)70)51(97)84(3)30-41(87)88/h31-40,42,86H,4-30,58-60H2,1-3H3,(H,76,90)(H,77,89)(H,78,93)(H,79,91)(H,80,92)(H,81,94)(H,82,96)(H,83,95)(H,87,88)(H4,61,62,71)(H4,63,64,72)(H4,65,66,73)(H4,67,68,74)(H4,69,70,75)/t31-,32+,33-,34-,35-,36-,37-,38-,39-,40-,42-/s2
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>100n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50270084
PNG
(CHEMBL507627 | TPRARRRKKR)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1/C54H105N27O12/c1-29(73-41(84)33(15-7-23-68-50(58)59)79-47(90)38-20-12-28-81(38)48(91)39(57)30(2)82)40(83)74-34(16-8-24-69-51(60)61)43(86)77-36(18-10-26-71-53(64)65)45(88)78-35(17-9-25-70-52(62)63)44(87)75-31(13-3-5-21-55)42(85)76-32(14-4-6-22-56)46(89)80-37(49(92)93)19-11-27-72-54(66)67/h29-39,82H,3-28,55-57H2,1-2H3,(H,73,84)(H,74,83)(H,75,87)(H,76,85)(H,77,86)(H,78,88)(H,79,90)(H,80,89)(H,92,93)(H4,58,59,68)(H4,60,61,69)(H4,62,63,70)(H4,64,65,71)(H4,66,67,72)/t29-,30+,31-,32-,33-,34-,35-,36-,37-,38-,39-/s2
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138n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Subtilisin/kexin type 5


(Homo sapiens (Human))
BDBM50270060
PNG
(CHEMBL455792 | TPQRARRRKKRT)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1/C63H120N30O16/c1-32(83-48(98)37(16-8-26-78-59(68)69)87-54(104)42(22-23-44(66)96)91-56(106)43-21-13-31-93(43)57(107)45(67)33(2)94)47(97)84-38(17-9-27-79-60(70)71)51(101)88-40(19-11-29-81-62(74)75)53(103)89-39(18-10-28-80-61(72)73)52(102)86-35(14-4-6-24-64)49(99)85-36(15-5-7-25-65)50(100)90-41(20-12-30-82-63(76)77)55(105)92-46(34(3)95)58(108)109/h32-43,45-46,94-95H,4-31,64-65,67H2,1-3H3,(H2,66,96)(H,83,98)(H,84,97)(H,85,99)(H,86,102)(H,87,104)(H,88,101)(H,89,103)(H,90,100)(H,91,106)(H,92,105)(H,108,109)(H4,68,69,78)(H4,70,71,79)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)/t32-,33+,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,45-,46-/s2
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188n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PC5/6 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Subtilisin/kexin type 7


(Homo sapiens (Human))
BDBM50270060
PNG
(CHEMBL455792 | TPQRARRRKKRT)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1/C63H120N30O16/c1-32(83-48(98)37(16-8-26-78-59(68)69)87-54(104)42(22-23-44(66)96)91-56(106)43-21-13-31-93(43)57(107)45(67)33(2)94)47(97)84-38(17-9-27-79-60(70)71)51(101)88-40(19-11-29-81-62(74)75)53(103)89-39(18-10-28-80-61(72)73)52(102)86-35(14-4-6-24-64)49(99)85-36(15-5-7-25-65)50(100)90-41(20-12-30-82-63(76)77)55(105)92-46(34(3)95)58(108)109/h32-43,45-46,94-95H,4-31,64-65,67H2,1-3H3,(H2,66,96)(H,83,98)(H,84,97)(H,85,99)(H,86,102)(H,87,104)(H,88,101)(H,89,103)(H,90,100)(H,91,106)(H,92,105)(H,108,109)(H4,68,69,78)(H4,70,71,79)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)/t32-,33+,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,45-,46-/s2
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206n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PC7 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 6


(Rattus norvegicus)
BDBM50270060
PNG
(CHEMBL455792 | TPQRARRRKKRT)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1/C63H120N30O16/c1-32(83-48(98)37(16-8-26-78-59(68)69)87-54(104)42(22-23-44(66)96)91-56(106)43-21-13-31-93(43)57(107)45(67)33(2)94)47(97)84-38(17-9-27-79-60(70)71)51(101)88-40(19-11-29-81-62(74)75)53(103)89-39(18-10-28-80-61(72)73)52(102)86-35(14-4-6-24-64)49(99)85-36(15-5-7-25-65)50(100)90-41(20-12-30-82-63(76)77)55(105)92-46(34(3)95)58(108)109/h32-43,45-46,94-95H,4-31,64-65,67H2,1-3H3,(H2,66,96)(H,83,98)(H,84,97)(H,85,99)(H,86,102)(H,87,104)(H,88,101)(H,89,103)(H,90,100)(H,91,106)(H,92,105)(H,108,109)(H4,68,69,78)(H4,70,71,79)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)/t32-,33+,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,45-,46-/s2
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296n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of rat PACE4 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair
Subtilisin/kexin type 4


(Homo sapiens (Human))
BDBM50270060
PNG
(CHEMBL455792 | TPQRARRRKKRT)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1/C63H120N30O16/c1-32(83-48(98)37(16-8-26-78-59(68)69)87-54(104)42(22-23-44(66)96)91-56(106)43-21-13-31-93(43)57(107)45(67)33(2)94)47(97)84-38(17-9-27-79-60(70)71)51(101)88-40(19-11-29-81-62(74)75)53(103)89-39(18-10-28-80-61(72)73)52(102)86-35(14-4-6-24-64)49(99)85-36(15-5-7-25-65)50(100)90-41(20-12-30-82-63(76)77)55(105)92-46(34(3)95)58(108)109/h32-43,45-46,94-95H,4-31,64-65,67H2,1-3H3,(H2,66,96)(H,83,98)(H,84,97)(H,85,99)(H,86,102)(H,87,104)(H,88,101)(H,89,103)(H,90,100)(H,91,106)(H,92,105)(H,108,109)(H4,68,69,78)(H4,70,71,79)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)/t32-,33+,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,45-,46-/s2
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515n/an/an/an/an/an/an/an/a



Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PC4 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage


J Biol Chem 282: 20847-53 (2007)


Article DOI: 10.1074/jbc.M703847200
BindingDB Entry DOI: 10.7270/Q2057FPB
More data for this
Ligand-Target Pair