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4 similar compounds to monomer 50270556

Wt: 215.2
BDBM50270560
Wt: 215.2
BDBM50271293
Wt: 201.2
BDBM50271255
Wt: 215.2
BDBM50271296

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50270560,50271293,50271255,50271296   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Imidazoline I1


(RAT)
BDBM50271255
PNG
(1-[(Imidazolidin-2-yl)imino]indazole hydrochloride...)
Show SMILES C1CNC(N1)=Nn1ncc2ccccc12
Show InChI InChI=1S/C10H11N5/c1-2-4-9-8(3-1)7-13-15(9)14-10-11-5-6-12-10/h1-4,7H,5-6H2,(H2,11,12,14)
UniProtKB/SwissProt

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PubMed
n/an/a 5.45E+4n/an/an/an/an/an/a



Medical University of Gda£?sk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline 1 receptor in Sprague-Dawley rat kidney


J Med Chem 51: 3599-608 (2008)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50270560
PNG
(2-[(Imidazolidin-2-yl)imino]-5-methylindazole hydr...)
Show SMILES Cc1ccc2nn(cc2c1)N=C1NCCN1
Show InChI InChI=1S/C11H13N5/c1-8-2-3-10-9(6-8)7-16(14-10)15-11-12-4-5-13-11/h2-3,6-7H,4-5H2,1H3,(H2,12,13,15)
UniProtKB/SwissProt

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Article
PubMed
n/an/a 1.34E+4n/an/an/an/an/an/a



Medical University of Gda£?sk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline 1 receptor in Sprague-Dawley rat kidney


J Med Chem 51: 3599-608 (2008)

More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50271255
PNG
(1-[(Imidazolidin-2-yl)imino]indazole hydrochloride...)
Show SMILES C1CNC(N1)=Nn1ncc2ccccc12
Show InChI InChI=1S/C10H11N5/c1-2-4-9-8(3-1)7-13-15(9)14-10-11-5-6-12-10/h1-4,7H,5-6H2,(H2,11,12,14)
UniProtKB/SwissProt

antibodypedia
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PubMed
n/an/an/an/a 160n/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...


Bioorg Med Chem 19: 321-9 (2011)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50271293
PNG
(1-[(Imidazolidin-2-yl)imino]-4-methylindazole hydr...)
Show SMILES Cc1cccc2n(N=C3NCCN3)ncc12
Show InChI InChI=1S/C11H13N5/c1-8-3-2-4-10-9(8)7-14-16(10)15-11-12-5-6-13-11/h2-4,7H,5-6H2,1H3,(H2,12,13,15)
UniProtKB/SwissProt

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PubMed
n/an/a 3.85E+4n/an/an/an/an/an/a



Medical University of Gda£?sk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline 1 receptor in Sprague-Dawley rat kidney


J Med Chem 51: 3599-608 (2008)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50271296
PNG
(1-[(Imidazolidin-2-yl)imino]-5-methylindazole hydr...)
Show SMILES Cc1ccc2n(N=C3NCCN3)ncc2c1
Show InChI InChI=1S/C11H13N5/c1-8-2-3-10-9(6-8)7-14-16(10)15-11-12-4-5-13-11/h2-3,6-7H,4-5H2,1H3,(H2,12,13,15)
UniProtKB/SwissProt

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Article
PubMed
n/an/a 2.03E+4n/an/an/an/an/an/a



Medical University of Gda£?sk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline 1 receptor in Sprague-Dawley rat kidney


J Med Chem 51: 3599-608 (2008)

More data for this
Ligand-Target Pair