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5 similar compounds to monomer 50393083

Wt: 354.4
BDBM50272919
Wt: 358.4
BDBM50272873
Wt: 396.5
BDBM50272874
Wt: 399.8
BDBM50393081
Wt: 399.8
BDBM50393082

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50272919,50272873,50272874,50393081,50393082   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tau


(Homo sapiens (Human))
BDBM50393081
PNG
(CHEMBL2152857)
Show SMILES Clc1ccc2[nH]cc(CCNC(=O)c3cccc(c3)-c3ccccc3C#N)c2c1
Show InChI InChI=1S/C24H18ClN3O/c25-20-8-9-23-22(13-20)19(15-28-23)10-11-27-24(29)17-6-3-5-16(12-17)21-7-2-1-4-18(21)14-26/h1-9,12-13,15,28H,10-11H2,(H,27,29)
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n/an/an/an/a 169n/an/an/an/a


TBA

Assay Description
Inhibition of Tau phosphorylation by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50393082
PNG
(CHEMBL2152858)
Show SMILES Clc1ccc2[nH]cc(CCNC(=O)c3ccc(cc3)-c3cccc(c3)C#N)c2c1
Show InChI InChI=1S/C24H18ClN3O/c25-21-8-9-23-22(13-21)20(15-28-23)10-11-27-24(29)18-6-4-17(5-7-18)19-3-1-2-16(12-19)14-26/h1-9,12-13,15,28H,10-11H2,(H,27,29)
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Article
n/an/an/an/a 24n/an/an/an/a


TBA

Assay Description
Inhibition of Tau phosphorylation by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-dependent kinase


(Homo sapiens (human))
BDBM50272919
PNG
(CHEMBL456121 | N-(2-(1H-Indol-3-yl)ethyl)-3'-methy...)
Show SMILES Cc1cccc(c1)-c1ccccc1C(=O)NCCc1c[nH]c2ccccc12
Show InChI InChI=1S/C24H22N2O/c1-17-7-6-8-18(15-17)20-9-2-3-11-22(20)24(27)25-14-13-19-16-26-23-12-5-4-10-21(19)23/h2-12,15-16,26H,13-14H2,1H3,(H,25,27)
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PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



University of Leicester

Curated by ChEMBL


Assay Description
Inhibition of human CDK4/GST-cyclin D1 expressed in Sf9 cells assessed as retinoblastoma GST-RB152 phosphorylation


Bioorg Med Chem 16: 7728-39 (2008)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase


(Homo sapiens (human))
BDBM50272873
PNG
(CHEMBL497454 | N-(2-(1H-Indol-3-yl)ethyl)-4'-fluor...)
Show SMILES Fc1ccc(cc1)-c1ccccc1C(=O)NCCc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H19FN2O/c24-18-11-9-16(10-12-18)19-5-1-2-7-21(19)23(27)25-14-13-17-15-26-22-8-4-3-6-20(17)22/h1-12,15,26H,13-14H2,(H,25,27)
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n/an/a 1.22E+6n/an/an/an/an/an/a



University of Leicester

Curated by ChEMBL


Assay Description
Inhibition of human CDK2/GST-cyclin A expressed in Sf9 cells assessed as histone phosphorylation


Bioorg Med Chem 16: 7728-39 (2008)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase


(Homo sapiens (human))
BDBM50272873
PNG
(CHEMBL497454 | N-(2-(1H-Indol-3-yl)ethyl)-4'-fluor...)
Show SMILES Fc1ccc(cc1)-c1ccccc1C(=O)NCCc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H19FN2O/c24-18-11-9-16(10-12-18)19-5-1-2-7-21(19)23(27)25-14-13-17-15-26-22-8-4-3-6-20(17)22/h1-12,15,26H,13-14H2,(H,25,27)
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n/an/a 3.80E+4n/an/an/an/an/an/a



University of Leicester

Curated by ChEMBL


Assay Description
Inhibition of human CDK4/GST-cyclin D1 expressed in Sf9 cells assessed as retinoblastoma GST-RB152 phosphorylation


Bioorg Med Chem 16: 7728-39 (2008)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase


(Homo sapiens (human))
BDBM50272919
PNG
(CHEMBL456121 | N-(2-(1H-Indol-3-yl)ethyl)-3'-methy...)
Show SMILES Cc1cccc(c1)-c1ccccc1C(=O)NCCc1c[nH]c2ccccc12
Show InChI InChI=1S/C24H22N2O/c1-17-7-6-8-18(15-17)20-9-2-3-11-22(20)24(27)25-14-13-19-16-26-23-12-5-4-10-21(19)23/h2-12,15-16,26H,13-14H2,1H3,(H,25,27)
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n/an/a 4.06E+5n/an/an/an/an/an/a



University of Leicester

Curated by ChEMBL


Assay Description
Inhibition of human CDK2/GST-cyclin A expressed in Sf9 cells assessed as histone phosphorylation


Bioorg Med Chem 16: 7728-39 (2008)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase


(Homo sapiens (human))
BDBM50272874
PNG
(CHEMBL525530 | N-(2-(1H-Indol-3-yl)ethyl)-4'-tert-...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccccc1C(=O)NCCc1c[nH]c2ccccc12
Show InChI InChI=1S/C27H28N2O/c1-27(2,3)21-14-12-19(13-15-21)22-8-4-5-10-24(22)26(30)28-17-16-20-18-29-25-11-7-6-9-23(20)25/h4-15,18,29H,16-17H2,1-3H3,(H,28,30)
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n/an/a 2.62E+5n/an/an/an/an/an/a



University of Leicester

Curated by ChEMBL


Assay Description
Inhibition of human CDK2/GST-cyclin A expressed in Sf9 cells assessed as histone phosphorylation


Bioorg Med Chem 16: 7728-39 (2008)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase


(Homo sapiens (human))
BDBM50272874
PNG
(CHEMBL525530 | N-(2-(1H-Indol-3-yl)ethyl)-4'-tert-...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccccc1C(=O)NCCc1c[nH]c2ccccc12
Show InChI InChI=1S/C27H28N2O/c1-27(2,3)21-14-12-19(13-15-21)22-8-4-5-10-24(22)26(30)28-17-16-20-18-29-25-11-7-6-9-23(20)25/h4-15,18,29H,16-17H2,1-3H3,(H,28,30)
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PubMed
n/an/a 3.80E+4n/an/an/an/an/an/a



University of Leicester

Curated by ChEMBL


Assay Description
Inhibition of human CDK4/GST-cyclin D1 expressed in Sf9 cells assessed as retinoblastoma GST-RB152 phosphorylation


Bioorg Med Chem 16: 7728-39 (2008)

More data for this
Ligand-Target Pair