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1 similar compounds to monomer 50273571

Compile data set for download or QSAR
Wt: 409.5
BDBM50279121

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50279121   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50279121
PNG
((Z)-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)...)
Show SMILES O=C1Nc2ccccc2C1C(=Nc1ccc(CN2CCCCC2)cc1)c1ccccc1
Show InChI InChI=1S/C27H27N3O/c31-27-25(23-11-5-6-12-24(23)29-27)26(21-9-3-1-4-10-21)28-22-15-13-20(14-16-22)19-30-17-7-2-8-18-30/h1,3-6,9-16,25H,2,7-8,17-19H2,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.11E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 expressed in Sf9 cells


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50279121
PNG
((Z)-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)...)
Show SMILES O=C1Nc2ccccc2C1C(=Nc1ccc(CN2CCCCC2)cc1)c1ccccc1
Show InChI InChI=1S/C27H27N3O/c31-27-25(23-11-5-6-12-24(23)29-27)26(21-9-3-1-4-10-21)28-22-15-13-20(14-16-22)19-30-17-7-2-8-18-30/h1,3-6,9-16,25H,2,7-8,17-19H2,(H,29,31)
PDB

KEGG

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.46E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH& Co KG

Curated by ChEMBL


Assay Description
Inhibition of TGFbeta receptor


J Med Chem 53: 7287-95 (2010)


Article DOI: 10.1021/jm100812a
BindingDB Entry DOI: 10.7270/Q2F47PCW
More data for this
Ligand-Target Pair