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6 similar compounds to monomer 50286905

Compile data set for download or QSAR
Wt: 461.5
BDBM50286906		Wt: 461.5
BDBM50286908		Wt: 475.5
BDBM50286909		Wt: 535.6
BDBM50286910		Wt: 501.5
BDBM50286912
Wt: 385.4
BDBM50286915

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50286906,50286908,50286909,50286910,50286912,50286915   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))		BDBM50286909
PNG
((S)-5-Biphenyl-4-yl-4-((R)-1-carboxy-ethylcarbamoy...)
Show SMILES C[C@@H](NC(=O)[C@@H](CC(COc1ccccc1)C(O)=O)Cc1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C28H29NO6/c1-19(27(31)32)29-26(30)23(17-24(28(33)34)18-35-25-10-6-3-7-11-25)16-20-12-14-22(15-13-20)21-8-4-2-5-9-21/h2-15,19,23-24H,16-18H2,1H3,(H,29,30)(H,31,32)(H,33,34)/t19-,23-,24?/m1/s1
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n/an/a 13n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase from rat kidney.

Bioorg Med Chem Lett 6: 65-70 (1996)


Article DOI: 10.1016/0960-894X(95)00551-4
BindingDB Entry DOI: 10.7270/Q2BZ66J9
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))		BDBM50286906
PNG
((2S,4S)-5-Biphenyl-4-yl-4-(carboxymethyl-carbamoyl...)
Show SMILES OC(=O)CNC(=O)[C@@H](C[C@@H](COc1ccccc1)C(O)=O)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H27NO6/c29-25(30)17-28-26(31)22(16-23(27(32)33)18-34-24-9-5-2-6-10-24)15-19-11-13-21(14-12-19)20-7-3-1-4-8-20/h1-14,22-23H,15-18H2,(H,28,31)(H,29,30)(H,32,33)/t22-,23+/m1/s1
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase from rat kidney.

Bioorg Med Chem Lett 6: 65-70 (1996)


Article DOI: 10.1016/0960-894X(95)00551-4
BindingDB Entry DOI: 10.7270/Q2BZ66J9
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))		BDBM50286908
PNG
((2R,4S)-5-Biphenyl-4-yl-4-(carboxymethyl-carbamoyl...)
Show SMILES OC(=O)CNC(=O)[C@@H](C[C@H](COc1ccccc1)C(O)=O)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H27NO6/c29-25(30)17-28-26(31)22(16-23(27(32)33)18-34-24-9-5-2-6-10-24)15-19-11-13-21(14-12-19)20-7-3-1-4-8-20/h1-14,22-23H,15-18H2,(H,28,31)(H,29,30)(H,32,33)/t22-,23-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase from rat kidney.

Bioorg Med Chem Lett 6: 65-70 (1996)


Article DOI: 10.1016/0960-894X(95)00551-4
BindingDB Entry DOI: 10.7270/Q2BZ66J9
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))		BDBM50286910
PNG
((S)-5-Biphenyl-4-yl-4-(1-carboxy-3-methylsulfanyl-...)
Show SMILES CSCCC(NC(=O)[C@@H](CC(COc1ccccc1)C(O)=O)Cc1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C30H33NO6S/c1-38-17-16-27(30(35)36)31-28(32)24(19-25(29(33)34)20-37-26-10-6-3-7-11-26)18-21-12-14-23(15-13-21)22-8-4-2-5-9-22/h2-15,24-25,27H,16-20H2,1H3,(H,31,32)(H,33,34)(H,35,36)/t24-,25?,27?/m1/s1
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n/an/a 101n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase from rat kidney.

Bioorg Med Chem Lett 6: 65-70 (1996)


Article DOI: 10.1016/0960-894X(95)00551-4
BindingDB Entry DOI: 10.7270/Q2BZ66J9
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))		BDBM50286912
PNG
(1-((S)-2-Biphenyl-4-ylmethyl-4-carboxy-5-phenoxy-p...)
Show SMILES OC(=O)C(COc1ccccc1)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCCC1C(O)=O
Show InChI InChI=1S/C30H31NO6/c32-28(31-17-7-12-27(31)30(35)36)24(19-25(29(33)34)20-37-26-10-5-2-6-11-26)18-21-13-15-23(16-14-21)22-8-3-1-4-9-22/h1-6,8-11,13-16,24-25,27H,7,12,17-20H2,(H,33,34)(H,35,36)/t24-,25?,27?/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase from rat kidney.

Bioorg Med Chem Lett 6: 65-70 (1996)


Article DOI: 10.1016/0960-894X(95)00551-4
BindingDB Entry DOI: 10.7270/Q2BZ66J9
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))		BDBM50286915
PNG
(4-(Carboxymethyl-carbamoyl)-2-phenoxymethyl-5-phen...)
Show SMILES OC(=O)CNC(=O)C(CC(COc1ccccc1)C(O)=O)Cc1ccccc1
Show InChI InChI=1S/C21H23NO6/c23-19(24)13-22-20(25)16(11-15-7-3-1-4-8-15)12-17(21(26)27)14-28-18-9-5-2-6-10-18/h1-10,16-17H,11-14H2,(H,22,25)(H,23,24)(H,26,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase from rat kidney.

Bioorg Med Chem Lett 6: 65-70 (1996)


Article DOI: 10.1016/0960-894X(95)00551-4
BindingDB Entry DOI: 10.7270/Q2BZ66J9
More data for this
Ligand-Target Pair
Neprilysin


(Rattus norvegicus (Rat))		BDBM50286912
PNG
(1-((S)-2-Biphenyl-4-ylmethyl-4-carboxy-5-phenoxy-p...)
Show SMILES OC(=O)C(COc1ccccc1)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCCC1C(O)=O
Show InChI InChI=1S/C30H31NO6/c32-28(31-17-7-12-27(31)30(35)36)24(19-25(29(33)34)20-37-26-10-5-2-6-11-26)18-21-13-15-23(16-14-21)22-8-3-1-4-9-22/h1-6,8-11,13-16,24-25,27H,7,12,17-20H2,(H,33,34)(H,35,36)/t24-,25?,27?/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Vascular endothelial growth factor receptor 2 (KDR)

Bioorg Med Chem Lett 6: 65-70 (1996)


Article DOI: 10.1016/0960-894X(95)00551-4
BindingDB Entry DOI: 10.7270/Q2BZ66J9
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))		BDBM50286906
PNG
((2S,4S)-5-Biphenyl-4-yl-4-(carboxymethyl-carbamoyl...)
Show SMILES OC(=O)CNC(=O)[C@@H](C[C@@H](COc1ccccc1)C(O)=O)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H27NO6/c29-25(30)17-28-26(31)22(16-23(27(32)33)18-34-24-9-5-2-6-10-24)15-19-11-13-21(14-12-19)20-7-3-1-4-8-20/h1-14,22-23H,15-18H2,(H,28,31)(H,29,30)(H,32,33)/t22-,23+/m1/s1
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Neutral Endopeptidase

Bioorg Med Chem Lett 6: 1487-1490 (1996)


Article DOI: 10.1016/S0960-894X(96)00255-7
BindingDB Entry DOI: 10.7270/Q2B27VSQ
More data for this
Ligand-Target Pair
Neprilysin


(Rattus norvegicus (Rat))		BDBM50286906
PNG
((2S,4S)-5-Biphenyl-4-yl-4-(carboxymethyl-carbamoyl...)
Show SMILES OC(=O)CNC(=O)[C@@H](C[C@@H](COc1ccccc1)C(O)=O)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H27NO6/c29-25(30)17-28-26(31)22(16-23(27(32)33)18-34-24-9-5-2-6-10-24)15-19-11-13-21(14-12-19)20-7-3-1-4-8-20/h1-14,22-23H,15-18H2,(H,28,31)(H,29,30)(H,32,33)/t22-,23+/m1/s1
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase from rat kidney.

Bioorg Med Chem Lett 6: 65-70 (1996)


Article DOI: 10.1016/0960-894X(95)00551-4
BindingDB Entry DOI: 10.7270/Q2BZ66J9
More data for this
Ligand-Target Pair
Neprilysin


(Rattus norvegicus (Rat))		BDBM50286909
PNG
((S)-5-Biphenyl-4-yl-4-((R)-1-carboxy-ethylcarbamoy...)
Show SMILES C[C@@H](NC(=O)[C@@H](CC(COc1ccccc1)C(O)=O)Cc1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C28H29NO6/c1-19(27(31)32)29-26(30)23(17-24(28(33)34)18-35-25-10-6-3-7-11-25)16-20-12-14-22(15-13-20)21-8-4-2-5-9-21/h2-15,19,23-24H,16-18H2,1H3,(H,29,30)(H,31,32)(H,33,34)/t19-,23-,24?/m1/s1
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase from rat kidney.

Bioorg Med Chem Lett 6: 65-70 (1996)


Article DOI: 10.1016/0960-894X(95)00551-4
BindingDB Entry DOI: 10.7270/Q2BZ66J9
More data for this
Ligand-Target Pair
Neprilysin


(Rattus norvegicus (Rat))		BDBM50286915
PNG
(4-(Carboxymethyl-carbamoyl)-2-phenoxymethyl-5-phen...)
Show SMILES OC(=O)CNC(=O)C(CC(COc1ccccc1)C(O)=O)Cc1ccccc1
Show InChI InChI=1S/C21H23NO6/c23-19(24)13-22-20(25)16(11-15-7-3-1-4-8-15)12-17(21(26)27)14-28-18-9-5-2-6-10-18/h1-10,16-17H,11-14H2,(H,22,25)(H,23,24)(H,26,27)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of neutral endopeptidase from rat kidney.

Bioorg Med Chem Lett 6: 65-70 (1996)


Article DOI: 10.1016/0960-894X(95)00551-4
BindingDB Entry DOI: 10.7270/Q2BZ66J9
More data for this
Ligand-Target Pair
Neprilysin


(Rattus norvegicus (Rat))		BDBM50286906
PNG
((2S,4S)-5-Biphenyl-4-yl-4-(carboxymethyl-carbamoyl...)
Show SMILES OC(=O)CNC(=O)[C@@H](C[C@@H](COc1ccccc1)C(O)=O)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H27NO6/c29-25(30)17-28-26(31)22(16-23(27(32)33)18-34-24-9-5-2-6-10-24)15-19-11-13-21(14-12-19)20-7-3-1-4-8-20/h1-14,22-23H,15-18H2,(H,28,31)(H,29,30)(H,32,33)/t22-,23+/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibition of Vascular endothelial growth factor receptor 2 (KDR)

Bioorg Med Chem Lett 6: 65-70 (1996)


Article DOI: 10.1016/0960-894X(95)00551-4
BindingDB Entry DOI: 10.7270/Q2BZ66J9
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))		BDBM50286908
PNG
((2R,4S)-5-Biphenyl-4-yl-4-(carboxymethyl-carbamoyl...)
Show SMILES OC(=O)CNC(=O)[C@@H](C[C@H](COc1ccccc1)C(O)=O)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H27NO6/c29-25(30)17-28-26(31)22(16-23(27(32)33)18-34-24-9-5-2-6-10-24)15-19-11-13-21(14-12-19)20-7-3-1-4-8-20/h1-14,22-23H,15-18H2,(H,28,31)(H,29,30)(H,32,33)/t22-,23-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of Neutral Endopeptidase

Bioorg Med Chem Lett 6: 1487-1490 (1996)


Article DOI: 10.1016/S0960-894X(96)00255-7
BindingDB Entry DOI: 10.7270/Q2B27VSQ
More data for this
Ligand-Target Pair