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3 similar compounds to monomer 50289373

Compile data set for download or QSAR
Wt: 459.5
BDBM50289375
Wt: 509.6
BDBM50289376
Wt: 509.6
BDBM50289378

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50289375,50289376,50289378   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM50289376
PNG
(2-(Naphthalene-2-sulfonylamino)-N-[(R)-1-(piperidi...)
Show SMILES O=C(CNS(=O)(=O)c1ccc2ccccc2c1)N[C@H](CCNc1ccncc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C26H31N5O4S/c32-25(19-29-36(34,35)23-9-8-20-6-2-3-7-21(20)18-23)30-24(26(33)31-16-4-1-5-17-31)12-15-28-22-10-13-27-14-11-22/h2-3,6-11,13-14,18,24,29H,1,4-5,12,15-17,19H2,(H,27,28)(H,30,32)/t24-/m1/s1
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200n/an/an/an/an/an/a7.5n/a



TBA

Curated by ChEMBL


Assay Description
Tested for the Inhibition of the catalytic activity of human Thrombin at 25 degree C and pH 7.5.


Bioorg Med Chem Lett 7: 1283-1288 (1997)


Article DOI: 10.1016/S0960-894X(97)00210-2
BindingDB Entry DOI: 10.7270/Q29W0FZ9
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM50289375
PNG
(2-Benzenesulfonylamino-N-[(R)-1-(piperidine-1-carb...)
Show SMILES O=C(CNS(=O)(=O)c1ccccc1)N[C@H](CCNc1ccncc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C22H29N5O4S/c28-21(17-25-32(30,31)19-7-3-1-4-8-19)26-20(22(29)27-15-5-2-6-16-27)11-14-24-18-9-12-23-13-10-18/h1,3-4,7-10,12-13,20,25H,2,5-6,11,14-17H2,(H,23,24)(H,26,28)/t20-/m1/s1
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1.00E+4n/an/an/an/an/an/a7.5n/a



TBA

Curated by ChEMBL


Assay Description
Tested for the Inhibition of the catalytic activity of human Thrombin at 25 degree C and pH 7.5.


Bioorg Med Chem Lett 7: 1283-1288 (1997)


Article DOI: 10.1016/S0960-894X(97)00210-2
BindingDB Entry DOI: 10.7270/Q29W0FZ9
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM50289378
PNG
(2-(Naphthalene-2-sulfonylamino)-N-[(S)-1-(piperidi...)
Show SMILES O=C(CNS(=O)(=O)c1ccc2ccccc2c1)N[C@@H](CCNc1ccncc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C26H31N5O4S/c32-25(19-29-36(34,35)23-9-8-20-6-2-3-7-21(20)18-23)30-24(26(33)31-16-4-1-5-17-31)12-15-28-22-10-13-27-14-11-22/h2-3,6-11,13-14,18,24,29H,1,4-5,12,15-17,19H2,(H,27,28)(H,30,32)/t24-/m0/s1
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3.00E+5n/an/an/an/an/an/a7.5n/a



TBA

Curated by ChEMBL


Assay Description
Tested for the Inhibition of the catalytic activity of human Thrombin at 25 degree C and pH 7.5.


Bioorg Med Chem Lett 7: 1283-1288 (1997)


Article DOI: 10.1016/S0960-894X(97)00210-2
BindingDB Entry DOI: 10.7270/Q29W0FZ9
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50289375
PNG
(2-Benzenesulfonylamino-N-[(R)-1-(piperidine-1-carb...)
Show SMILES O=C(CNS(=O)(=O)c1ccccc1)N[C@H](CCNc1ccncc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C22H29N5O4S/c28-21(17-25-32(30,31)19-7-3-1-4-8-19)26-20(22(29)27-15-5-2-6-16-27)11-14-24-18-9-12-23-13-10-18/h1,3-4,7-10,12-13,20,25H,2,5-6,11,14-17H2,(H,23,24)(H,26,28)/t20-/m1/s1
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>5.00E+5n/an/an/an/an/an/a7.5n/a



TBA

Curated by ChEMBL


Assay Description
Tested for the Inhibition of the catalytic activity of human plasmin at 25 degree C and pH 7.5.


Bioorg Med Chem Lett 7: 1283-1288 (1997)


Article DOI: 10.1016/S0960-894X(97)00210-2
BindingDB Entry DOI: 10.7270/Q29W0FZ9
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50289376
PNG
(2-(Naphthalene-2-sulfonylamino)-N-[(R)-1-(piperidi...)
Show SMILES O=C(CNS(=O)(=O)c1ccc2ccccc2c1)N[C@H](CCNc1ccncc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C26H31N5O4S/c32-25(19-29-36(34,35)23-9-8-20-6-2-3-7-21(20)18-23)30-24(26(33)31-16-4-1-5-17-31)12-15-28-22-10-13-27-14-11-22/h2-3,6-11,13-14,18,24,29H,1,4-5,12,15-17,19H2,(H,27,28)(H,30,32)/t24-/m1/s1
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>5.00E+5n/an/an/an/an/an/a7.5n/a



TBA

Curated by ChEMBL


Assay Description
Tested for the Inhibition of the catalytic activity of human plasmin at 25 degree C and pH 7.5.


Bioorg Med Chem Lett 7: 1283-1288 (1997)


Article DOI: 10.1016/S0960-894X(97)00210-2
BindingDB Entry DOI: 10.7270/Q29W0FZ9
More data for this
Ligand-Target Pair
Trypsin


(Bos taurus (bovine))
BDBM50289375
PNG
(2-Benzenesulfonylamino-N-[(R)-1-(piperidine-1-carb...)
Show SMILES O=C(CNS(=O)(=O)c1ccccc1)N[C@H](CCNc1ccncc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C22H29N5O4S/c28-21(17-25-32(30,31)19-7-3-1-4-8-19)26-20(22(29)27-15-5-2-6-16-27)11-14-24-18-9-12-23-13-10-18/h1,3-4,7-10,12-13,20,25H,2,5-6,11,14-17H2,(H,23,24)(H,26,28)/t20-/m1/s1
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>5.00E+5n/an/an/an/an/an/a7.5n/a



TBA

Curated by ChEMBL


Assay Description
Tested for the Inhibition of the catalytic activity of bovine trypsin at 25 degree C and pH 7.5.


Bioorg Med Chem Lett 7: 1283-1288 (1997)


Article DOI: 10.1016/S0960-894X(97)00210-2
BindingDB Entry DOI: 10.7270/Q29W0FZ9
More data for this
Ligand-Target Pair
Trypsin


(Bos taurus (bovine))
BDBM50289376
PNG
(2-(Naphthalene-2-sulfonylamino)-N-[(R)-1-(piperidi...)
Show SMILES O=C(CNS(=O)(=O)c1ccc2ccccc2c1)N[C@H](CCNc1ccncc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C26H31N5O4S/c32-25(19-29-36(34,35)23-9-8-20-6-2-3-7-21(20)18-23)30-24(26(33)31-16-4-1-5-17-31)12-15-28-22-10-13-27-14-11-22/h2-3,6-11,13-14,18,24,29H,1,4-5,12,15-17,19H2,(H,27,28)(H,30,32)/t24-/m1/s1
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Article
>5.00E+5n/an/an/an/an/an/a7.5n/a



TBA

Curated by ChEMBL


Assay Description
Tested for the Inhibition of the catalytic activity of bovine trypsin at 25 degree C and pH 7.5.


Bioorg Med Chem Lett 7: 1283-1288 (1997)


Article DOI: 10.1016/S0960-894X(97)00210-2
BindingDB Entry DOI: 10.7270/Q29W0FZ9
More data for this
Ligand-Target Pair
Trypsin


(Bos taurus (bovine))
BDBM50289378
PNG
(2-(Naphthalene-2-sulfonylamino)-N-[(S)-1-(piperidi...)
Show SMILES O=C(CNS(=O)(=O)c1ccc2ccccc2c1)N[C@@H](CCNc1ccncc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C26H31N5O4S/c32-25(19-29-36(34,35)23-9-8-20-6-2-3-7-21(20)18-23)30-24(26(33)31-16-4-1-5-17-31)12-15-28-22-10-13-27-14-11-22/h2-3,6-11,13-14,18,24,29H,1,4-5,12,15-17,19H2,(H,27,28)(H,30,32)/t24-/m0/s1
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Article
>5.00E+5n/an/an/an/an/an/a7.5n/a



TBA

Curated by ChEMBL


Assay Description
Tested for the Inhibition of the catalytic activity of bovine trypsin at 25 degree C and pH 7.5.


Bioorg Med Chem Lett 7: 1283-1288 (1997)


Article DOI: 10.1016/S0960-894X(97)00210-2
BindingDB Entry DOI: 10.7270/Q29W0FZ9
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50289378
PNG
(2-(Naphthalene-2-sulfonylamino)-N-[(S)-1-(piperidi...)
Show SMILES O=C(CNS(=O)(=O)c1ccc2ccccc2c1)N[C@@H](CCNc1ccncc1)C(=O)N1CCCCC1
Show InChI InChI=1S/C26H31N5O4S/c32-25(19-29-36(34,35)23-9-8-20-6-2-3-7-21(20)18-23)30-24(26(33)31-16-4-1-5-17-31)12-15-28-22-10-13-27-14-11-22/h2-3,6-11,13-14,18,24,29H,1,4-5,12,15-17,19H2,(H,27,28)(H,30,32)/t24-/m0/s1
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Article
>5.00E+5n/an/an/an/an/an/a7.5n/a



TBA

Curated by ChEMBL


Assay Description
Tested for the Inhibition of the catalytic activity of human plasmin at 25 degree C and pH 7.5.


Bioorg Med Chem Lett 7: 1283-1288 (1997)


Article DOI: 10.1016/S0960-894X(97)00210-2
BindingDB Entry DOI: 10.7270/Q29W0FZ9
More data for this
Ligand-Target Pair