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1 similar compounds to monomer 50293549

Compile data set for download or QSAR
Wt: 551.6
BDBM50293551

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50293551   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50293551
PNG
(3-{3-[3-(3-Biphenyl-2-yl-ureido)-phenyl]-1H-pyrrol...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cnc2[nH]cc(-c3cccc(NC(=O)Nc4ccccc4-c4ccccc4)c3)c2c1
Show InChI InChI=1S/C35H29N5O2/c1-40(2)34(41)26-14-8-12-24(18-26)27-20-30-31(22-37-33(30)36-21-27)25-13-9-15-28(19-25)38-35(42)39-32-17-7-6-16-29(32)23-10-4-3-5-11-23/h3-22H,1-2H3,(H,36,37)(H2,38,39,42)
PDB
MMDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 385n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of IGF1-induced human IGF1R phosphorylation expressed in mouse NIH-3T3 cells treated 2 hrs prior to IGF1 challenge by DELFIA


Bioorg Med Chem Lett 19: 3136-40 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.110
BindingDB Entry DOI: 10.7270/Q2DV1KSP
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50293551
PNG
(3-{3-[3-(3-Biphenyl-2-yl-ureido)-phenyl]-1H-pyrrol...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cnc2[nH]cc(-c3cccc(NC(=O)Nc4ccccc4-c4ccccc4)c3)c2c1
Show InChI InChI=1S/C35H29N5O2/c1-40(2)34(41)26-14-8-12-24(18-26)27-20-30-31(22-37-33(30)36-21-27)25-13-9-15-28(19-25)38-35(42)39-32-17-7-6-16-29(32)23-10-4-3-5-11-23/h3-22H,1-2H3,(H,36,37)(H2,38,39,42)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 64n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human IGF1R expressed in Sf9-baculovirus system


Bioorg Med Chem Lett 19: 3136-40 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.110
BindingDB Entry DOI: 10.7270/Q2DV1KSP
More data for this
Ligand-Target Pair