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10 similar compounds to monomer 50300101

Compile data set for download or QSAR
Wt: 365.4
BDBM50300100
Wt: 377.4
BDBM50300102
Wt: 391.5
BDBM50300103
Wt: 393.4
BDBM50300107
Wt: 411.4
BDBM50397844
Wt: 411.4
BDBM50397845
Wt: 411.4
BDBM50397846
Wt: 407.5
BDBM50397848
Wt: 393.4
BDBM50397849
Wt: 393.4
BDBM50397851
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50300100,50300102,50300103,50300107,50397844,50397845,50397846,50397848,50397849,50397851   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50300100
PNG
(CHEMBL576952 | trans-6-(1-benzyl-4-methylpyrrolidi...)
Show SMILES CC(C)Cn1ncc2c1nc([nH]c2=O)[C@@H]1CN(Cc2ccccc2)C[C@H]1C
Show InChI InChI=1S/C21H27N5O/c1-14(2)10-26-20-17(9-22-26)21(27)24-19(23-20)18-13-25(11-15(18)3)12-16-7-5-4-6-8-16/h4-9,14-15,18H,10-13H2,1-3H3,(H,23,24,27)/t15-,18-/m1/s1
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n/an/a 150n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM50397851
PNG
(CHEMBL2179094)
Show SMILES C[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H27N5O2/c1-15-12-26(13-16-5-3-2-4-6-16)14-19(15)20-24-21-18(22(28)25-20)11-23-27(21)17-7-9-29-10-8-17/h2-6,11,15,17,19H,7-10,12-14H2,1H3,(H,24,25,28)/t15-,19-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells using [3H]cAMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)


Article DOI: 10.1021/jm3007799
BindingDB Entry DOI: 10.7270/Q24J0G79
More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50300102
PNG
(CHEMBL572747 | trans-6-(1-benzyl-4-methylpyrrolidi...)
Show SMILES C[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCCC1
Show InChI InChI=1S/C22H27N5O/c1-15-12-26(13-16-7-3-2-4-8-16)14-19(15)20-24-21-18(22(28)25-20)11-23-27(21)17-9-5-6-10-17/h2-4,7-8,11,15,17,19H,5-6,9-10,12-14H2,1H3,(H,24,25,28)/t15-,19-/m1/s1
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n/an/a 63n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50300103
PNG
(CHEMBL575745 | trans-1-cyclopentyl-6-(4-methyl-1-(...)
Show SMILES C[C@@H]1CN(Cc2cccc(C)c2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCCC1
Show InChI InChI=1S/C23H29N5O/c1-15-6-5-7-17(10-15)13-27-12-16(2)20(14-27)21-25-22-19(23(29)26-21)11-24-28(22)18-8-3-4-9-18/h5-7,10-11,16,18,20H,3-4,8-9,12-14H2,1-2H3,(H,25,26,29)/t16-,20-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50300100
PNG
(CHEMBL576952 | trans-6-(1-benzyl-4-methylpyrrolidi...)
Show SMILES CC(C)Cn1ncc2c1nc([nH]c2=O)[C@@H]1CN(Cc2ccccc2)C[C@H]1C
Show InChI InChI=1S/C21H27N5O/c1-14(2)10-26-20-17(9-22-26)21(27)24-19(23-20)18-13-25(11-15(18)3)12-16-7-5-4-6-8-16/h4-9,14-15,18H,10-13H2,1-3H3,(H,23,24,27)/t15-,18-/m1/s1
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n/an/a 150n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM50300102
PNG
(CHEMBL572747 | trans-6-(1-benzyl-4-methylpyrrolidi...)
Show SMILES C[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCCC1
Show InChI InChI=1S/C22H27N5O/c1-15-12-26(13-16-7-3-2-4-8-16)14-19(15)20-24-21-18(22(28)25-20)11-23-27(21)17-9-5-6-10-17/h2-4,7-8,11,15,17,19H,5-6,9-10,12-14H2,1H3,(H,24,25,28)/t15-,19-/m1/s1
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n/an/a 970n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM50300103
PNG
(CHEMBL575745 | trans-1-cyclopentyl-6-(4-methyl-1-(...)
Show SMILES C[C@@H]1CN(Cc2cccc(C)c2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCCC1
Show InChI InChI=1S/C23H29N5O/c1-15-6-5-7-17(10-15)13-27-12-16(2)20(14-27)21-25-22-19(23(29)26-21)11-24-28(22)18-8-3-4-9-18/h5-7,10-11,16,18,20H,3-4,8-9,12-14H2,1-2H3,(H,25,26,29)/t16-,20-/m1/s1
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n/an/a 563n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50300102
PNG
(CHEMBL572747 | trans-6-(1-benzyl-4-methylpyrrolidi...)
Show SMILES C[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCCC1
Show InChI InChI=1S/C22H27N5O/c1-15-12-26(13-16-7-3-2-4-8-16)14-19(15)20-24-21-18(22(28)25-20)11-23-27(21)17-9-5-6-10-17/h2-4,7-8,11,15,17,19H,5-6,9-10,12-14H2,1H3,(H,24,25,28)/t15-,19-/m1/s1
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n/an/a 63n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50300103
PNG
(CHEMBL575745 | trans-1-cyclopentyl-6-(4-methyl-1-(...)
Show SMILES C[C@@H]1CN(Cc2cccc(C)c2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCCC1
Show InChI InChI=1S/C23H29N5O/c1-15-6-5-7-17(10-15)13-27-12-16(2)20(14-27)21-25-22-19(23(29)26-21)11-24-28(22)18-8-3-4-9-18/h5-7,10-11,16,18,20H,3-4,8-9,12-14H2,1-2H3,(H,25,26,29)/t16-,20-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50300107
PNG
(CHEMBL578033 | trans-1-cyclopentyl-6-(4-methyl-1-(...)
Show SMILES C[C@@H]1CN(Cc2cnc(C)nc2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCCC1
Show InChI InChI=1S/C21H27N7O/c1-13-10-27(11-15-7-22-14(2)23-8-15)12-18(13)19-25-20-17(21(29)26-19)9-24-28(20)16-5-3-4-6-16/h7-9,13,16,18H,3-6,10-12H2,1-2H3,(H,25,26,29)/t13-,18-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM50300107
PNG
(CHEMBL578033 | trans-1-cyclopentyl-6-(4-methyl-1-(...)
Show SMILES C[C@@H]1CN(Cc2cnc(C)nc2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCCC1
Show InChI InChI=1S/C21H27N7O/c1-13-10-27(11-15-7-22-14(2)23-8-15)12-18(13)19-25-20-17(21(29)26-19)9-24-28(20)16-5-3-4-6-16/h7-9,13,16,18H,3-6,10-12H2,1-2H3,(H,25,26,29)/t13-,18-/m1/s1
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n/an/a 407n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM50300100
PNG
(CHEMBL576952 | trans-6-(1-benzyl-4-methylpyrrolidi...)
Show SMILES CC(C)Cn1ncc2c1nc([nH]c2=O)[C@@H]1CN(Cc2ccccc2)C[C@H]1C
Show InChI InChI=1S/C21H27N5O/c1-14(2)10-26-20-17(9-22-26)21(27)24-19(23-20)18-13-25(11-15(18)3)12-16-7-5-4-6-8-16/h4-9,14-15,18H,10-13H2,1-3H3,(H,23,24,27)/t15-,18-/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM50300100
PNG
(CHEMBL576952 | trans-6-(1-benzyl-4-methylpyrrolidi...)
Show SMILES CC(C)Cn1ncc2c1nc([nH]c2=O)[C@@H]1CN(Cc2ccccc2)C[C@H]1C
Show InChI InChI=1S/C21H27N5O/c1-14(2)10-26-20-17(9-22-26)21(27)24-19(23-20)18-13-25(11-15(18)3)12-16-7-5-4-6-8-16/h4-9,14-15,18H,10-13H2,1-3H3,(H,23,24,27)/t15-,18-/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM50300103
PNG
(CHEMBL575745 | trans-1-cyclopentyl-6-(4-methyl-1-(...)
Show SMILES C[C@@H]1CN(Cc2cccc(C)c2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCCC1
Show InChI InChI=1S/C23H29N5O/c1-15-6-5-7-17(10-15)13-27-12-16(2)20(14-27)21-25-22-19(23(29)26-21)11-24-28(22)18-8-3-4-9-18/h5-7,10-11,16,18,20H,3-4,8-9,12-14H2,1-2H3,(H,25,26,29)/t16-,20-/m1/s1
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n/an/a 563n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM50397844
PNG
(CHEMBL2179099)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H26FN5O2/c1-14-11-27(12-15-2-4-16(23)5-3-15)13-19(14)20-25-21-18(22(29)26-20)10-24-28(21)17-6-8-30-9-7-17/h2-5,10,14,17,19H,6-9,11-13H2,1H3,(H,25,26,29)/t14-,19-/m1/s1
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n/an/a 165n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells using [3H]cAMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)


Article DOI: 10.1021/jm3007799
BindingDB Entry DOI: 10.7270/Q24J0G79
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM50397845
PNG
(CHEMBL2177125)
Show SMILES C[C@@H]1CN(Cc2cccc(F)c2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H26FN5O2/c1-14-11-27(12-15-3-2-4-16(23)9-15)13-19(14)20-25-21-18(22(29)26-20)10-24-28(21)17-5-7-30-8-6-17/h2-4,9-10,14,17,19H,5-8,11-13H2,1H3,(H,25,26,29)/t14-,19-/m1/s1
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n/an/a 693n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells using [3H]cAMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)


Article DOI: 10.1021/jm3007799
BindingDB Entry DOI: 10.7270/Q24J0G79
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM50397846
PNG
(CHEMBL2179098)
Show SMILES C[C@@H]1CN(Cc2ccccc2F)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H26FN5O2/c1-14-11-27(12-15-4-2-3-5-19(15)23)13-18(14)20-25-21-17(22(29)26-20)10-24-28(21)16-6-8-30-9-7-16/h2-5,10,14,16,18H,6-9,11-13H2,1H3,(H,25,26,29)/t14-,18-/m1/s1
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n/an/a 889n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells using [3H]cAMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)


Article DOI: 10.1021/jm3007799
BindingDB Entry DOI: 10.7270/Q24J0G79
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM50397848
PNG
(CHEMBL2179096)
Show SMILES CC[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C23H29N5O2/c1-2-17-14-27(13-16-6-4-3-5-7-16)15-20(17)21-25-22-19(23(29)26-21)12-24-28(22)18-8-10-30-11-9-18/h3-7,12,17-18,20H,2,8-11,13-15H2,1H3,(H,25,26,29)/t17-,20-/m1/s1
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n/an/a 431n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells using [3H]cAMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)


Article DOI: 10.1021/jm3007799
BindingDB Entry DOI: 10.7270/Q24J0G79
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM50397849
PNG
(CHEMBL2179095)
Show SMILES C[C@H]1CN(Cc2ccccc2)C[C@@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H27N5O2/c1-15-12-26(13-16-5-3-2-4-6-16)14-19(15)20-24-21-18(22(28)25-20)11-23-27(21)17-7-9-29-10-8-17/h2-6,11,15,17,19H,7-10,12-14H2,1H3,(H,24,25,28)/t15-,19-/m0/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells using [3H]cAMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)


Article DOI: 10.1021/jm3007799
BindingDB Entry DOI: 10.7270/Q24J0G79
More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50397844
PNG
(CHEMBL2179099)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H26FN5O2/c1-14-11-27(12-15-2-4-16(23)5-3-15)13-19(14)20-25-21-18(22(29)26-20)10-24-28(21)17-6-8-30-9-7-17/h2-5,10,14,17,19H,6-9,11-13H2,1H3,(H,25,26,29)/t14-,19-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)


Article DOI: 10.1021/jm3007799
BindingDB Entry DOI: 10.7270/Q24J0G79
More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50397845
PNG
(CHEMBL2177125)
Show SMILES C[C@@H]1CN(Cc2cccc(F)c2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H26FN5O2/c1-14-11-27(12-15-3-2-4-16(23)9-15)13-19(14)20-25-21-18(22(29)26-20)10-24-28(21)17-5-7-30-8-6-17/h2-4,9-10,14,17,19H,5-8,11-13H2,1H3,(H,25,26,29)/t14-,19-/m1/s1
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n/an/a 1.20n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)


Article DOI: 10.1021/jm3007799
BindingDB Entry DOI: 10.7270/Q24J0G79
More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50397846
PNG
(CHEMBL2179098)
Show SMILES C[C@@H]1CN(Cc2ccccc2F)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H26FN5O2/c1-14-11-27(12-15-4-2-3-5-19(15)23)13-18(14)20-25-21-17(22(29)26-20)10-24-28(21)16-6-8-30-9-7-16/h2-5,10,14,16,18H,6-9,11-13H2,1H3,(H,25,26,29)/t14-,18-/m1/s1
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n/an/a 4.60n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)


Article DOI: 10.1021/jm3007799
BindingDB Entry DOI: 10.7270/Q24J0G79
More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50397848
PNG
(CHEMBL2179096)
Show SMILES CC[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C23H29N5O2/c1-2-17-14-27(13-16-6-4-3-5-7-16)15-20(17)21-25-22-19(23(29)26-21)12-24-28(22)18-8-10-30-11-9-18/h3-7,12,17-18,20H,2,8-11,13-15H2,1H3,(H,25,26,29)/t17-,20-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)


Article DOI: 10.1021/jm3007799
BindingDB Entry DOI: 10.7270/Q24J0G79
More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50397849
PNG
(CHEMBL2179095)
Show SMILES C[C@H]1CN(Cc2ccccc2)C[C@@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H27N5O2/c1-15-12-26(13-16-5-3-2-4-6-16)14-19(15)20-24-21-18(22(28)25-20)11-23-27(21)17-7-9-29-10-8-17/h2-6,11,15,17,19H,7-10,12-14H2,1H3,(H,24,25,28)/t15-,19-/m0/s1
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n/an/a 152n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)


Article DOI: 10.1021/jm3007799
BindingDB Entry DOI: 10.7270/Q24J0G79
More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (Human))
BDBM50397851
PNG
(CHEMBL2179094)
Show SMILES C[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1
Show InChI InChI=1S/C22H27N5O2/c1-15-12-26(13-16-5-3-2-4-6-16)14-19(15)20-24-21-18(22(28)25-20)11-23-27(21)17-7-9-29-10-8-17/h2-6,11,15,17,19H,7-10,12-14H2,1H3,(H,24,25,28)/t15-,19-/m1/s1
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n/an/a 4.90n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assay


J Med Chem 55: 9045-54 (2012)


Article DOI: 10.1021/jm3007799
BindingDB Entry DOI: 10.7270/Q24J0G79
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C


(Homo sapiens (Human))
BDBM50300102
PNG
(CHEMBL572747 | trans-6-(1-benzyl-4-methylpyrrolidi...)
Show SMILES C[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCCC1
Show InChI InChI=1S/C22H27N5O/c1-15-12-26(13-16-7-3-2-4-8-16)14-19(15)20-24-21-18(22(28)25-20)11-23-27(21)17-9-5-6-10-17/h2-4,7-8,11,15,17,19H,5-6,9-10,12-14H2,1H3,(H,24,25,28)/t15-,19-/m1/s1
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n/an/a 970n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE1C expressed in Sf9 cells by SPA


J Med Chem 52: 7946-9 (2009)


Article DOI: 10.1021/jm9015334
BindingDB Entry DOI: 10.7270/Q2RV0NRS
More data for this
Ligand-Target Pair