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20 similar compounds to monomer 50303738

Compile data set for download or QSAR
Wt: 405.4
BDBM50303716
Wt: 404.4
BDBM50303717
Wt: 386.4
BDBM50303719
Wt: 400.4
BDBM50303720
Wt: 440.5
BDBM50303724
Wt: 411.4
BDBM50303725
Wt: 386.4
BDBM50303726
Wt: 422.4
BDBM50303727
Wt: 402.4
BDBM50303733
Wt: 397.4
BDBM50303736
Wt: 387.4
BDBM50303739
Wt: 390.4
BDBM50303745
Wt: 422.4
BDBM50303747
Wt: 444.3
BDBM50303757
Wt: 384.4
BDBM50303758
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 88 hits for monomerid = 50303716,50303717,50303719,50303720,50303724,50303725,50303726,50303727,50303733,50303736,50303739,50303745,50303747,50303757,50303758   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303736
PNG
(5-(2-amino-1-methyl-5-oxo-4-(3-(pyridin-3-yl)pheny...)
Show SMILES COc1ccc(cc1C#N)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C23H19N5O2/c1-28-21(29)23(27-22(28)25,19-8-9-20(30-2)17(12-19)13-24)18-7-3-5-15(11-18)16-6-4-10-26-14-16/h3-12,14H,1-2H3,(H2,25,27)
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n/an/an/an/a 4.50E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303727
PNG
((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Show SMILES COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F
Show InChI InChI=1/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/s2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303757
PNG
(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methy...)
Show SMILES CN1C(N)=NC(C1=O)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F
Show InChI InChI=1/C22H16F4N4O2/c1-30-19(31)21(29-20(30)27,14-7-9-16(10-8-14)32-22(24,25)26)15-5-2-4-13(12-15)17-6-3-11-28-18(17)23/h2-12H,1H3,(H2,27,29)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303736
PNG
(5-(2-amino-1-methyl-5-oxo-4-(3-(pyridin-3-yl)pheny...)
Show SMILES COc1ccc(cc1C#N)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C23H19N5O2/c1-28-21(29)23(27-22(28)25,19-8-9-20(30-2)17(12-19)13-24)18-7-3-5-15(11-18)16-6-4-10-26-14-16/h3-12,14H,1-2H3,(H2,25,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303716
PNG
(2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4-(4...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cncnc1
Show InChI InChI=1/C22H20FN5O2/c1-13-8-15(5-7-19(13)30-3)22(20(29)28(2)21(24)27-22)16-4-6-18(23)17(9-16)14-10-25-12-26-11-14/h4-12H,1-3H3,(H2,24,27)
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n/an/a 20n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303716
PNG
(2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4-(4...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cncnc1
Show InChI InChI=1/C22H20FN5O2/c1-13-8-15(5-7-19(13)30-3)22(20(29)28(2)21(24)27-22)16-4-6-18(23)17(9-16)14-10-25-12-26-11-14/h4-12H,1-3H3,(H2,24,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303719
PNG
(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C23H22N4O2/c1-15-12-19(9-10-20(15)29-3)23(21(28)27(2)22(24)26-23)18-8-4-6-16(13-18)17-7-5-11-25-14-17/h4-14H,1-3H3,(H2,24,26)
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n/an/an/an/a 120n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303733
PNG
(2-amino-4-(3,4-dimethoxyphenyl)-1-methyl-4-(3-(pyr...)
Show SMILES COc1ccc(cc1OC)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C23H22N4O3/c1-27-21(28)23(26-22(27)24,18-9-10-19(29-2)20(13-18)30-3)17-8-4-6-15(12-17)16-7-5-11-25-14-16/h4-14H,1-3H3,(H2,24,26)
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n/an/an/an/a 900n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303757
PNG
(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methy...)
Show SMILES CN1C(N)=NC(C1=O)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F
Show InChI InChI=1/C22H16F4N4O2/c1-30-19(31)21(29-20(30)27,14-7-9-16(10-8-14)32-22(24,25)26)15-5-2-4-13(12-15)17-6-3-11-28-18(17)23/h2-12H,1H3,(H2,27,29)
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n/an/a 60n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303727
PNG
((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Show SMILES COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F
Show InChI InChI=1/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/s2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303717
PNG
(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(4-me...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F
Show InChI InChI=1/C23H21FN4O2/c1-14-12-17(9-10-19(14)30-3)23(21(29)28(2)22(25)27-23)16-7-4-6-15(13-16)18-8-5-11-26-20(18)24/h4-13H,1-3H3,(H2,25,27)
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n/an/an/an/a 110n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303739
PNG
(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1
Show InChI InChI=1/C22H21N5O2/c1-14-9-18(7-8-19(14)29-3)22(20(28)27(2)21(23)26-22)17-6-4-5-15(10-17)16-11-24-13-25-12-16/h4-13H,1-3H3,(H2,23,26)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303717
PNG
(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(4-me...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F
Show InChI InChI=1/C23H21FN4O2/c1-14-12-17(9-10-19(14)30-3)23(21(29)28(2)22(25)27-23)16-7-4-6-15(13-16)18-8-5-11-26-20(18)24/h4-13H,1-3H3,(H2,25,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303739
PNG
(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1
Show InChI InChI=1/C22H21N5O2/c1-14-9-18(7-8-19(14)29-3)22(20(28)27(2)21(23)26-22)17-6-4-5-15(10-17)16-11-24-13-25-12-16/h4-13H,1-3H3,(H2,23,26)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303720
PNG
(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(4...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1ccc(C)c(c1)-c1cccnc1
Show InChI InChI=1/C24H24N4O2/c1-15-7-8-19(13-20(15)17-6-5-11-26-14-17)24(22(29)28(3)23(25)27-24)18-9-10-21(30-4)16(2)12-18/h5-14H,1-4H3,(H2,25,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303725
PNG
(4-(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-5...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1ccc(C#N)c(c1)-c1cccnc1
Show InChI InChI=1/C24H21N5O2/c1-15-11-18(8-9-21(15)31-3)24(22(30)29(2)23(26)28-24)19-7-6-16(13-25)20(12-19)17-5-4-10-27-14-17/h4-12,14H,1-3H3,(H2,26,28)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303724
PNG
(2-amino-4-(3-cyclopentyl-4-methoxyphenyl)-1-methyl...)
Show SMILES COc1ccc(cc1C1CCCC1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C27H28N4O2/c1-31-25(32)27(30-26(31)28,21-11-5-9-19(15-21)20-10-6-14-29-17-20)22-12-13-24(33-2)23(16-22)18-7-3-4-8-18/h5-6,9-18H,3-4,7-8H2,1-2H3,(H2,28,30)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 2


(Homo sapiens (Human))
BDBM50303727
PNG
((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Show SMILES COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F
Show InChI InChI=1/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/s2
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n/an/a 1.64E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE2 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303758
PNG
(2-amino-4-(2,3-dihydrobenzofuran-5-yl)-1-methyl-4-...)
Show SMILES CN1C(N)=NC(C1=O)(c1ccc2OCCc2c1)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C23H20N4O2/c1-27-21(28)23(26-22(27)24,19-7-8-20-16(13-19)9-11-29-20)18-6-2-4-15(12-18)17-5-3-10-25-14-17/h2-8,10,12-14H,9,11H2,1H3,(H2,24,26)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303726
PNG
(2-amino-4-(benzo[d][1,3]dioxol-5-yl)-1-methyl-4-(3...)
Show SMILES CN1C(N)=NC(C1=O)(c1ccc2OCOc2c1)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C22H18N4O3/c1-26-20(27)22(25-21(26)23,17-7-8-18-19(11-17)29-13-28-18)16-6-2-4-14(10-16)15-5-3-9-24-12-15/h2-12H,13H2,1H3,(H2,23,25)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303758
PNG
(2-amino-4-(2,3-dihydrobenzofuran-5-yl)-1-methyl-4-...)
Show SMILES CN1C(N)=NC(C1=O)(c1ccc2OCCc2c1)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C23H20N4O2/c1-27-21(28)23(26-22(27)24,19-7-8-20-16(13-19)9-11-29-20)18-6-2-4-15(12-18)17-5-3-10-25-14-17/h2-8,10,12-14H,9,11H2,1H3,(H2,24,26)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303726
PNG
(2-amino-4-(benzo[d][1,3]dioxol-5-yl)-1-methyl-4-(3...)
Show SMILES CN1C(N)=NC(C1=O)(c1ccc2OCOc2c1)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C22H18N4O3/c1-26-20(27)22(25-21(26)23,17-7-8-18-19(11-17)29-13-28-18)16-6-2-4-14(10-16)15-5-3-9-24-12-15/h2-12H,13H2,1H3,(H2,23,25)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303720
PNG
(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(4...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1ccc(C)c(c1)-c1cccnc1
Show InChI InChI=1/C24H24N4O2/c1-15-7-8-19(13-20(15)17-6-5-11-26-14-17)24(22(29)28(3)23(25)27-24)18-9-10-21(30-4)16(2)12-18/h5-14H,1-4H3,(H2,25,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303725
PNG
(4-(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-5...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1ccc(C#N)c(c1)-c1cccnc1
Show InChI InChI=1/C24H21N5O2/c1-15-11-18(8-9-21(15)31-3)24(22(30)29(2)23(26)28-24)19-7-6-16(13-25)20(12-19)17-5-4-10-27-14-17/h4-12,14H,1-3H3,(H2,26,28)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303727
PNG
((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Show SMILES COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F
Show InChI InChI=1/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/s2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Cathepsin D


(Homo sapiens (Human))
BDBM50303727
PNG
((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Show SMILES COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F
Show InChI InChI=1/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/s2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin D by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303747
PNG
((4S)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Show SMILES COc1ccc(cc1C)[C@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F
Show InChI InChI=1/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/s2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303724
PNG
(2-amino-4-(3-cyclopentyl-4-methoxyphenyl)-1-methyl...)
Show SMILES COc1ccc(cc1C1CCCC1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C27H28N4O2/c1-31-25(32)27(30-26(31)28,21-11-5-9-19(15-21)20-10-6-14-29-17-20)22-12-13-24(33-2)23(16-22)18-7-3-4-8-18/h5-6,9-18H,3-4,7-8H2,1-2H3,(H2,28,30)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303745
PNG
(2-amino-4-(3-fluoro-4-methoxyphenyl)-1-methyl-4-(3...)
Show SMILES COc1ccc(cc1F)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C22H19FN4O2/c1-27-20(28)22(26-21(27)24,17-8-9-19(29-2)18(23)12-17)16-7-3-5-14(11-16)15-6-4-10-25-13-15/h3-13H,1-2H3,(H2,24,26)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303745
PNG
(2-amino-4-(3-fluoro-4-methoxyphenyl)-1-methyl-4-(3...)
Show SMILES COc1ccc(cc1F)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C22H19FN4O2/c1-27-20(28)22(26-21(27)24,17-8-9-19(29-2)18(23)12-17)16-7-3-5-14(11-16)15-6-4-10-25-13-15/h3-13H,1-2H3,(H2,24,26)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303719
PNG
(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C23H22N4O2/c1-15-12-19(9-10-20(15)29-3)23(21(28)27(2)22(24)26-23)18-8-4-6-16(13-18)17-7-5-11-25-14-17/h4-14H,1-3H3,(H2,24,26)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303733
PNG
(2-amino-4-(3,4-dimethoxyphenyl)-1-methyl-4-(3-(pyr...)
Show SMILES COc1ccc(cc1OC)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C23H22N4O3/c1-27-21(28)23(26-22(27)24,18-9-10-19(29-2)20(13-18)30-3)17-8-4-6-15(12-17)16-7-5-11-25-14-16/h4-14H,1-3H3,(H2,24,26)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET based peptide cleavage assay


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303747
PNG
((4S)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Show SMILES COc1ccc(cc1C)[C@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F
Show InChI InChI=1/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/s2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303727
PNG
((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Show SMILES COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F
Show InChI InChI=1/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/s2
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA


J Med Chem 53: 1146-58 (2010)


Article DOI: 10.1021/jm901414e
BindingDB Entry DOI: 10.7270/Q2SX6DBS
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303727
PNG
((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Show SMILES COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F
Show InChI InChI=1/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/s2
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Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of BACE1 by cell-based assay


Bioorg Med Chem Lett 20: 6597-605 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.029
BindingDB Entry DOI: 10.7270/Q2C829JF
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303727
PNG
((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Show SMILES COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F
Show InChI InChI=1/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/s2
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Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET assay


Bioorg Med Chem Lett 20: 6597-605 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.029
BindingDB Entry DOI: 10.7270/Q2C829JF
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303719
PNG
(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C23H22N4O2/c1-15-12-19(9-10-20(15)29-3)23(21(28)27(2)22(24)26-23)18-8-4-6-16(13-18)17-7-5-11-25-14-17/h4-14H,1-3H3,(H2,24,26)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET assay


Bioorg Med Chem 18: 630-9 (2010)


Article DOI: 10.1016/j.bmc.2009.12.007
BindingDB Entry DOI: 10.7270/Q2DV1KT4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303717
PNG
(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(4-me...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F
Show InChI InChI=1/C23H21FN4O2/c1-14-12-17(9-10-19(14)30-3)23(21(29)28(2)22(25)27-23)16-7-4-6-15(13-16)18-8-5-11-26-20(18)24/h4-13H,1-3H3,(H2,25,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human BACE1 by FRET assay


Bioorg Med Chem 18: 630-9 (2010)


Article DOI: 10.1016/j.bmc.2009.12.007
BindingDB Entry DOI: 10.7270/Q2DV1KT4
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303758
PNG
(2-amino-4-(2,3-dihydrobenzofuran-5-yl)-1-methyl-4-...)
Show SMILES CN1C(N)=NC(C1=O)(c1ccc2OCCc2c1)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C23H20N4O2/c1-27-21(28)23(26-22(27)24,19-7-8-20-16(13-19)9-11-29-20)18-6-2-4-15(12-18)17-5-3-10-25-14-17/h2-8,10,12-14H,9,11H2,1H3,(H2,24,26)
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n/an/a 120n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human BACE1


Eur J Med Chem 46: 58-64 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.014
BindingDB Entry DOI: 10.7270/Q2P55PRK
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303716
PNG
(2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4-(4...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cncnc1
Show InChI InChI=1/C22H20FN5O2/c1-13-8-15(5-7-19(13)30-3)22(20(29)28(2)21(24)27-22)16-4-6-18(23)17(9-16)14-10-25-12-26-11-14/h4-12H,1-3H3,(H2,24,27)
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n/an/a 20n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human BACE1


Eur J Med Chem 46: 58-64 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.014
BindingDB Entry DOI: 10.7270/Q2P55PRK
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303720
PNG
(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(4...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1ccc(C)c(c1)-c1cccnc1
Show InChI InChI=1/C24H24N4O2/c1-15-7-8-19(13-20(15)17-6-5-11-26-14-17)24(22(29)28(3)23(25)27-24)18-9-10-21(30-4)16(2)12-18/h5-14H,1-4H3,(H2,25,27)
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n/an/a 130n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human BACE1


Eur J Med Chem 46: 58-64 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.014
BindingDB Entry DOI: 10.7270/Q2P55PRK
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303733
PNG
(2-amino-4-(3,4-dimethoxyphenyl)-1-methyl-4-(3-(pyr...)
Show SMILES COc1ccc(cc1OC)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C23H22N4O3/c1-27-21(28)23(26-22(27)24,18-9-10-19(29-2)20(13-18)30-3)17-8-4-6-15(12-17)16-7-5-11-25-14-16/h4-14H,1-3H3,(H2,24,26)
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n/an/a 90n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human BACE1


Eur J Med Chem 46: 58-64 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.014
BindingDB Entry DOI: 10.7270/Q2P55PRK
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303719
PNG
(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C23H22N4O2/c1-15-12-19(9-10-20(15)29-3)23(21(28)27(2)22(24)26-23)18-8-4-6-16(13-18)17-7-5-11-25-14-17/h4-14H,1-3H3,(H2,24,26)
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n/an/a 40n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human BACE1


Eur J Med Chem 46: 58-64 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.014
BindingDB Entry DOI: 10.7270/Q2P55PRK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303724
PNG
(2-amino-4-(3-cyclopentyl-4-methoxyphenyl)-1-methyl...)
Show SMILES COc1ccc(cc1C1CCCC1)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C27H28N4O2/c1-31-25(32)27(30-26(31)28,21-11-5-9-19(15-21)20-10-6-14-29-17-20)22-12-13-24(33-2)23(16-22)18-7-3-4-8-18/h5-6,9-18H,3-4,7-8H2,1-2H3,(H2,28,30)
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n/an/a 120n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human BACE1


Eur J Med Chem 46: 58-64 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.014
BindingDB Entry DOI: 10.7270/Q2P55PRK
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303739
PNG
(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cncnc1
Show InChI InChI=1/C22H21N5O2/c1-14-9-18(7-8-19(14)29-3)22(20(28)27(2)21(23)26-22)17-6-4-5-15(10-17)16-11-24-13-25-12-16/h4-13H,1-3H3,(H2,23,26)
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n/an/a 30n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human BACE1


Eur J Med Chem 46: 58-64 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.014
BindingDB Entry DOI: 10.7270/Q2P55PRK
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303717
PNG
(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(4-me...)
Show SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F
Show InChI InChI=1/C23H21FN4O2/c1-14-12-17(9-10-19(14)30-3)23(21(29)28(2)22(25)27-23)16-7-4-6-15(13-16)18-8-5-11-26-20(18)24/h4-13H,1-3H3,(H2,25,27)
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n/an/a 20n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human BACE1


Eur J Med Chem 46: 58-64 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.014
BindingDB Entry DOI: 10.7270/Q2P55PRK
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303745
PNG
(2-amino-4-(3-fluoro-4-methoxyphenyl)-1-methyl-4-(3...)
Show SMILES COc1ccc(cc1F)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C22H19FN4O2/c1-27-20(28)22(26-21(27)24,17-8-9-19(29-2)18(23)12-17)16-7-3-5-14(11-16)15-6-4-10-25-13-15/h3-13H,1-2H3,(H2,24,26)
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n/an/a 50n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human BACE1


Eur J Med Chem 46: 58-64 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.014
BindingDB Entry DOI: 10.7270/Q2P55PRK
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303736
PNG
(5-(2-amino-1-methyl-5-oxo-4-(3-(pyridin-3-yl)pheny...)
Show SMILES COc1ccc(cc1C#N)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1
Show InChI InChI=1/C23H19N5O2/c1-28-21(29)23(27-22(28)25,19-8-9-20(30-2)17(12-19)13-24)18-7-3-5-15(11-18)16-6-4-10-26-14-16/h3-12,14H,1-2H3,(H2,25,27)
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n/an/a 150n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human BACE1


Eur J Med Chem 46: 58-64 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.014
BindingDB Entry DOI: 10.7270/Q2P55PRK
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303727
PNG
((4R)-2-amino-4-(4-fluoro-3-(2-fluoropyridin-3-yl)p...)
Show SMILES COc1ccc(cc1C)[C@@]1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F
Show InChI InChI=1/C23H20F2N4O2/c1-13-11-14(7-9-19(13)31-3)23(21(30)29(2)22(26)28-23)15-6-8-18(24)17(12-15)16-5-4-10-27-20(16)25/h4-12H,1-3H3,(H2,26,28)/t23-/s2
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n/an/a 10n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human BACE1


Eur J Med Chem 46: 58-64 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.014
BindingDB Entry DOI: 10.7270/Q2P55PRK
More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM50303757
PNG
(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methy...)
Show SMILES CN1C(N)=NC(C1=O)(c1ccc(OC(F)(F)F)cc1)c1cccc(c1)-c1cccnc1F
Show InChI InChI=1/C22H16F4N4O2/c1-30-19(31)21(29-20(30)27,14-7-9-16(10-8-14)32-22(24,25)26)15-5-2-4-13(12-15)17-6-3-11-28-18(17)23/h2-12H,1H3,(H2,27,29)
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n/an/a 60n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human BACE1


Eur J Med Chem 46: 58-64 (2010)


Article DOI: 10.1016/j.ejmech.2010.10.014
BindingDB Entry DOI: 10.7270/Q2P55PRK
More data for this
Ligand-Target Pair
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