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23 similar compounds to monomer 50346048

Compile data set for download or QSAR
Wt: 319.4
BDBM50305261
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Wt: 304.4
BDBM50305263
Wt: 358.4
BDBM50305265
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Wt: 334.4
BDBM50305269
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Wt: 372.4
BDBM50305270
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Wt: 322.4
BDBM50305271
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Wt: 318.4
BDBM50305272
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Wt: 291.3
BDBM50346053
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Wt: 388.5
BDBM50346055
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Wt: 305.4
BDBM50346059
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Wt: 305.4
BDBM50346061
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Wt: 359.3
BDBM50346062
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Wt: 388.5
BDBM50346064
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Wt: 359.3
BDBM50346043
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Wt: 291.3
BDBM50346044
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Displayed 1 to 15 (of 23 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 54 hits for monomerid = 50305261,50305263,50305265,50305269,50305270,50305271,50305272,50346053,50346055,50346059,50346061,50346062,50346064,50346043,50346044   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50305263
PNG
(2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1
Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3
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1.20n/an/an/an/an/an/an/an/a



Universit£ di Catania

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT2c receptor (unknown origin)


J Med Chem 61: 8475-8503 (2018)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50305263
PNG
(2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1
Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3
PDB
MMDB

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1.20n/an/an/an/an/an/an/an/a



Universit£ di Catania

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT2A receptor (unknown origin)


J Med Chem 61: 8475-8503 (2018)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305263
PNG
(2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1
Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3
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1.20n/an/an/an/an/an/an/an/a



Universit£ di Catania

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT6 receptor (unknown origin)


J Med Chem 61: 8475-8503 (2018)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305263
PNG
(2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1
Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3
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3n/an/an/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells


J Med Chem 57: 7160-81 (2014)


Article DOI: 10.1021/jm5003952
BindingDB Entry DOI: 10.7270/Q2X92CZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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PubMed
8n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to 5HT7 receptor by radioligand displacement assay


Eur J Med Chem 45: 782-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.10.035
BindingDB Entry DOI: 10.7270/Q2542NR1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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26n/an/an/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells


J Med Chem 57: 7160-81 (2014)


Article DOI: 10.1021/jm5003952
BindingDB Entry DOI: 10.7270/Q2X92CZZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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26n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant 5HT6 receptor


Eur J Med Chem 45: 782-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.10.035
BindingDB Entry DOI: 10.7270/Q2542NR1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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34n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant 5HT6 receptor by radioligand displacement assay


Eur J Med Chem 45: 782-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.10.035
BindingDB Entry DOI: 10.7270/Q2542NR1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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76n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to 5HT2C receptor by radioligand displacement assay


Eur J Med Chem 45: 782-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.10.035
BindingDB Entry DOI: 10.7270/Q2542NR1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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>100n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to 5HT1A receptor by radioligand displacement assay


Eur J Med Chem 45: 782-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.10.035
BindingDB Entry DOI: 10.7270/Q2542NR1
More data for this
Ligand-Target Pair
HTR6


(RAT)
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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PubMed
119n/an/an/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Binding affinity to rat recombinant 5HT6 receptor


Eur J Med Chem 45: 782-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.10.035
BindingDB Entry DOI: 10.7270/Q2542NR1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50305263
PNG
(2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1
Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3
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153n/an/an/an/an/an/an/an/a



Universit£ di Catania

Curated by ChEMBL


Assay Description
Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)


J Med Chem 61: 8475-8503 (2018)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305265
PNG
(2-Methyl-5-phenethyl-8-trifluoromethyl-2,3,4,5-tet...)
Show SMILES CN1CCc2c(C1)c1cc(ccc1n2CCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C21H21F3N2/c1-25-11-10-20-18(14-25)17-13-16(21(22,23)24)7-8-19(17)26(20)12-9-15-5-3-2-4-6-15/h2-8,13H,9-12,14H2,1H3
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n/an/a 974n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...


Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305269
PNG
(5-[2-(4-Methoxyphenyl)ethyl]-2,8-dimethyl-2,3,4,5-...)
Show SMILES COc1ccc(CCn2c3CCN(C)Cc3c3cc(C)ccc23)cc1
Show InChI InChI=1S/C22H26N2O/c1-16-4-9-21-19(14-16)20-15-23(2)12-11-22(20)24(21)13-10-17-5-7-18(25-3)8-6-17/h4-9,14H,10-13,15H2,1-3H3
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n/an/a 666n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...


Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305270
PNG
(2,8-Dimethyl-5-[2-(4-trifluoromethylphenyl)ethyl]-...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N2/c1-15-3-8-20-18(13-15)19-14-26(2)11-10-21(19)27(20)12-9-16-4-6-17(7-5-16)22(23,24)25/h3-8,13H,9-12,14H2,1-2H3
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n/an/a 4.07E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...


Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305271
PNG
(5-[2-(4-Fluorophenyl)ethyl]-2,8-dimethyl-2,3,4,5-t...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(F)cc1
Show InChI InChI=1S/C21H23FN2/c1-15-3-8-20-18(13-15)19-14-23(2)11-10-21(19)24(20)12-9-16-4-6-17(22)7-5-16/h3-8,13H,9-12,14H2,1-2H3
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PubMed
n/an/a 977n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...


Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305272
PNG
(2,8-Dimethyl-5-(2-p-tolylethyl)-2,3,4,5-tetrahydro...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)cc1
Show InChI InChI=1S/C22H26N2/c1-16-4-7-18(8-5-16)10-13-24-21-9-6-17(2)14-19(21)20-15-23(3)12-11-22(20)24/h4-9,14H,10-13,15H2,1-3H3
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n/an/a 276n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...


Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305263
PNG
(2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1
Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3
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n/an/a 158n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...


Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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n/an/a 890n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production by LANCE...


Eur J Med Chem 45: 782-9 (2010)


Article DOI: 10.1016/j.ejmech.2009.10.035
BindingDB Entry DOI: 10.7270/Q2542NR1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50346043
PNG
(2-methyl-5-(2-(pyridin-3-yl)ethyl)-8-(trifluoromet...)
Show SMILES CN1CCc2c(C1)c1cc(ccc1n2CCc1cccnc1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N3/c1-25-9-7-19-17(13-25)16-11-15(20(21,22)23)4-5-18(16)26(19)10-6-14-3-2-8-24-12-14/h2-5,8,11-12H,6-7,9-10,13H2,1H3
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n/an/a 5.80E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular cAMP accu...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50346044
PNG
(2-methyl-5-(2-(pyridin-3-yl)ethyl)-2,3,4,5-tetrahy...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2CCc1cccnc1
Show InChI InChI=1S/C19H21N3/c1-21-11-9-19-17(14-21)16-6-2-3-7-18(16)22(19)12-8-15-5-4-10-20-13-15/h2-7,10,13H,8-9,11-12,14H2,1H3
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n/an/a 5.99E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular cAMP accu...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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MMDB

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n/an/a 7.90E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Inhibition of BuChE


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50346053
PNG
(2-methyl-5-(2-(pyridin-2-yl)ethyl)-2,3,4,5-tetrahy...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2CCc1ccccn1
Show InChI InChI=1S/C19H21N3/c1-21-12-10-19-17(14-21)16-7-2-3-8-18(16)22(19)13-9-15-6-4-5-11-20-15/h2-8,11H,9-10,12-14H2,1H3
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n/an/a 1.58E+4n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular cAMP accu...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Cholinesterases


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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n/an/a 4.50E+4n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Inhibition of AChE


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50346043
PNG
(2-methyl-5-(2-(pyridin-3-yl)ethyl)-8-(trifluoromet...)
Show SMILES CN1CCc2c(C1)c1cc(ccc1n2CCc1cccnc1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N3/c1-25-9-7-19-17(13-25)16-11-15(20(21,22)23)4-5-18(16)26(19)10-6-14-3-2-8-24-12-14/h2-5,8,11-12H,6-7,9-10,13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50346055
PNG
(8-methyl-2-(1-methylpiperidin-4-yl)-5-(2-(pyridin-...)
Show SMILES CN1CCC(CC1)N1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccn1
Show InChI InChI=1S/C25H32N4/c1-19-6-7-24-22(17-19)23-18-28(21-9-13-27(2)14-10-21)15-11-25(23)29(24)16-8-20-5-3-4-12-26-20/h3-7,12,17,21H,8-11,13-16,18H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50346044
PNG
(2-methyl-5-(2-(pyridin-3-yl)ethyl)-2,3,4,5-tetrahy...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2CCc1cccnc1
Show InChI InChI=1S/C19H21N3/c1-21-11-9-19-17(14-21)16-6-2-3-7-18(16)22(19)12-8-15-5-4-10-20-13-15/h2-7,10,13H,8-9,11-12,14H2,1H3
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n/an/a 100n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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n/an/a 160n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50346059
PNG
(2,8-dimethyl-5-(2-(pyridin-4-yl)ethyl)-2,3,4,5-tet...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccncc1
Show InChI InChI=1S/C20H23N3/c1-15-3-4-19-17(13-15)18-14-22(2)11-8-20(18)23(19)12-7-16-5-9-21-10-6-16/h3-6,9-10,13H,7-8,11-12,14H2,1-2H3
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n/an/a 160n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50346059
PNG
(2,8-dimethyl-5-(2-(pyridin-4-yl)ethyl)-2,3,4,5-tet...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccncc1
Show InChI InChI=1S/C20H23N3/c1-15-3-4-19-17(13-15)18-14-22(2)11-8-20(18)23(19)12-7-16-5-9-21-10-6-16/h3-6,9-10,13H,7-8,11-12,14H2,1-2H3
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n/an/a 370n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular cAMP accu...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50346044
PNG
(2-methyl-5-(2-(pyridin-3-yl)ethyl)-2,3,4,5-tetrahy...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2CCc1cccnc1
Show InChI InChI=1S/C19H21N3/c1-21-11-9-19-17(14-21)16-6-2-3-7-18(16)22(19)12-8-15-5-4-10-20-13-15/h2-7,10,13H,8-9,11-12,14H2,1H3
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n/an/a 410n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50346061
PNG
(2,8-dimethyl-5-(2-(pyridin-3-yl)ethyl)-2,3,4,5-tet...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1cccnc1
Show InChI InChI=1S/C20H23N3/c1-15-5-6-19-17(12-15)18-14-22(2)10-8-20(18)23(19)11-7-16-4-3-9-21-13-16/h3-6,9,12-13H,7-8,10-11,14H2,1-2H3
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n/an/a 440n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular cAMP accu...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50346061
PNG
(2,8-dimethyl-5-(2-(pyridin-3-yl)ethyl)-2,3,4,5-tet...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1cccnc1
Show InChI InChI=1S/C20H23N3/c1-15-5-6-19-17(12-15)18-14-22(2)10-8-20(18)23(19)11-7-16-4-3-9-21-13-16/h3-6,9,12-13H,7-8,10-11,14H2,1-2H3
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n/an/a 500n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50346062
PNG
(2-methyl-5-(2-(pyridin-2-yl)ethyl)-8-(trifluoromet...)
Show SMILES CN1CCc2c(C1)c1cc(ccc1n2CCc1ccccn1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N3/c1-25-10-8-19-17(13-25)16-12-14(20(21,22)23)5-6-18(16)26(19)11-7-15-4-2-3-9-24-15/h2-6,9,12H,7-8,10-11,13H2,1H3
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n/an/a 560n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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n/an/a 890n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular cAMP accu...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50346053
PNG
(2-methyl-5-(2-(pyridin-2-yl)ethyl)-2,3,4,5-tetrahy...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2CCc1ccccn1
Show InChI InChI=1S/C19H21N3/c1-21-12-10-19-17(14-21)16-7-2-3-8-18(16)22(19)13-9-15-6-4-5-11-20-15/h2-8,11H,9-10,12-14H2,1H3
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n/an/a 930n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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n/an/a 1.58E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50346062
PNG
(2-methyl-5-(2-(pyridin-2-yl)ethyl)-8-(trifluoromet...)
Show SMILES CN1CCc2c(C1)c1cc(ccc1n2CCc1ccccn1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N3/c1-25-10-8-19-17(13-25)16-12-14(20(21,22)23)5-6-18(16)26(19)11-7-15-4-2-3-9-24-15/h2-6,9,12H,7-8,10-11,13H2,1H3
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n/an/a 1.59E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50346062
PNG
(2-methyl-5-(2-(pyridin-2-yl)ethyl)-8-(trifluoromet...)
Show SMILES CN1CCc2c(C1)c1cc(ccc1n2CCc1ccccn1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N3/c1-25-10-8-19-17(13-25)16-12-14(20(21,22)23)5-6-18(16)26(19)11-7-15-4-2-3-9-24-15/h2-6,9,12H,7-8,10-11,13H2,1H3
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n/an/a 1.59E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular cAMP accu...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50346053
PNG
(2-methyl-5-(2-(pyridin-2-yl)ethyl)-2,3,4,5-tetrahy...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2CCc1ccccn1
Show InChI InChI=1S/C19H21N3/c1-21-12-10-19-17(14-21)16-7-2-3-8-18(16)22(19)13-9-15-6-4-5-11-20-15/h2-8,11H,9-10,12-14H2,1H3
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n/an/a 1.82E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50346064
PNG
(8-methyl-2-(1-methylpiperidin-4-yl)-5-(2-(pyridin-...)
Show SMILES CN1CCC(CC1)N1CCc2c(C1)c1cc(C)ccc1n2CCc1cccnc1
Show InChI InChI=1S/C25H32N4/c1-19-5-6-24-22(16-19)23-18-28(21-8-12-27(2)13-9-21)14-10-25(23)29(24)15-7-20-4-3-11-26-17-20/h3-6,11,16-17,21H,7-10,12-15,18H2,1-2H3
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n/an/a 2.79E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50346061
PNG
(2,8-dimethyl-5-(2-(pyridin-3-yl)ethyl)-2,3,4,5-tet...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1cccnc1
Show InChI InChI=1S/C20H23N3/c1-15-5-6-19-17(12-15)18-14-22(2)10-8-20(18)23(19)11-7-16-4-3-9-21-13-16/h3-6,9,12-13H,7-8,10-11,14H2,1-2H3
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n/an/a 3.16E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50346059
PNG
(2,8-dimethyl-5-(2-(pyridin-4-yl)ethyl)-2,3,4,5-tet...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccncc1
Show InChI InChI=1S/C20H23N3/c1-15-3-4-19-17(13-15)18-14-22(2)11-8-20(18)23(19)12-7-16-5-9-21-10-6-16/h3-6,9-10,13H,7-8,11-12,14H2,1-2H3
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n/an/a 3.98E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound...


Bioorg Med Chem Lett 19: 3183-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.128
BindingDB Entry DOI: 10.7270/Q2FJ2H4X
More data for this
Ligand-Target Pair
Bile salt export pump


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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n/an/a 1.36E+5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...


Drug Metab Dispos 40: 2332-41 (2012)


Article DOI: 10.1124/dmd.112.047068
BindingDB Entry DOI: 10.7270/Q2ZP488M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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n/an/a 1.16E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...


Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50305263
PNG
(2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1
Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3
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n/an/a 40n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...


Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50305272
PNG
(2,8-Dimethyl-5-(2-p-tolylethyl)-2,3,4,5-tetrahydro...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)cc1
Show InChI InChI=1S/C22H26N2/c1-16-4-7-18(8-5-16)10-13-24-21-9-6-17(2)14-19(21)20-15-23(3)12-11-22(20)24/h4-9,14H,10-13,15H2,1-3H3
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n/an/a 112n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...


Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50305271
PNG
(5-[2-(4-Fluorophenyl)ethyl]-2,8-dimethyl-2,3,4,5-t...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(F)cc1
Show InChI InChI=1S/C21H23FN2/c1-15-3-8-20-18(13-15)19-14-23(2)11-10-21(19)24(20)12-9-16-4-6-17(22)7-5-16/h3-8,13H,9-12,14H2,1-2H3
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n/an/a 30n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...


Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50305270
PNG
(2,8-Dimethyl-5-[2-(4-trifluoromethylphenyl)ethyl]-...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N2/c1-15-3-8-20-18(13-15)19-14-26(2)11-10-21(19)27(20)12-9-16-4-6-17(7-5-16)22(23,24)25/h3-8,13H,9-12,14H2,1-2H3
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n/an/a 98n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...


Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50305269
PNG
(5-[2-(4-Methoxyphenyl)ethyl]-2,8-dimethyl-2,3,4,5-...)
Show SMILES COc1ccc(CCn2c3CCN(C)Cc3c3cc(C)ccc23)cc1
Show InChI InChI=1S/C22H26N2O/c1-16-4-9-21-19(14-16)20-15-23(2)12-11-22(20)24(21)13-10-17-5-7-18(25-3)8-6-17/h4-9,14H,10-13,15H2,1-3H3
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n/an/a 66n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...


Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
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