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9 similar compounds to monomer 50310810

Compile data set for download or QSAR
Wt: 372.8
BDBM50310793
Wt: 386.8
BDBM50310808
Wt: 454.8
BDBM50310809
Wt: 387.8
BDBM50310812
Wt: 454.8
BDBM50310816
Wt: 372.8
BDBM50310819
Wt: 400.8
BDBM50310820
Wt: 414.9
BDBM50310821
Wt: 400.8
BDBM50310822

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 63 hits for monomerid = 50310793,50310808,50310809,50310812,50310816,50310819,50310820,50310821,50310822   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
EBifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50310793
PNG
(CHEMBL1079291 | N-(4-chlorophenyl)-3-(3-hydroxypro...)
Show SMILES OCCCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H25ClN2O2/c22-18-8-10-19(11-9-18)23-20(26)24-14-4-12-21(16-24,13-5-15-25)17-6-2-1-3-7-17/h1-3,6-11,25H,4-5,12-16H2,(H,23,26)
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n/an/a 1.30n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310822
PNG
(CHEMBL1078754 | methyl 3-(1-(4-chlorophenylcarbamo...)
Show SMILES COC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C22H25ClN2O3/c1-28-20(26)12-14-22(17-6-3-2-4-7-17)13-5-15-25(16-22)21(27)24-19-10-8-18(23)9-11-19/h2-4,6-11H,5,12-16H2,1H3,(H,24,27)
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n/an/a 3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Epoxide hydrolase 1


(Homo sapiens (Human))
BDBM50310793
PNG
(CHEMBL1079291 | N-(4-chlorophenyl)-3-(3-hydroxypro...)
Show SMILES OCCCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H25ClN2O2/c22-18-8-10-19(11-9-18)23-20(26)24-14-4-12-21(16-24,13-5-15-25)17-6-2-1-3-7-17/h1-3,6-11,25H,4-5,12-16H2,(H,23,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human microsomal epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50310793
PNG
(CHEMBL1079291 | N-(4-chlorophenyl)-3-(3-hydroxypro...)
Show SMILES OCCCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H25ClN2O2/c22-18-8-10-19(11-9-18)23-20(26)24-14-4-12-21(16-24,13-5-15-25)17-6-2-1-3-7-17/h1-3,6-11,25H,4-5,12-16H2,(H,23,26)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50310793
PNG
(CHEMBL1079291 | N-(4-chlorophenyl)-3-(3-hydroxypro...)
Show SMILES OCCCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H25ClN2O2/c22-18-8-10-19(11-9-18)23-20(26)24-14-4-12-21(16-24,13-5-15-25)17-6-2-1-3-7-17/h1-3,6-11,25H,4-5,12-16H2,(H,23,26)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Nav1.5 channel


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
EBifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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n/an/a 5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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n/an/a 69n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
EBifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Nav1.5 channel


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
EBifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50310809
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(2-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-15-6-8-16(9-7-15)27-20(31)28-13-3-11-21(14-28,12-10-19(29)30)17-4-1-2-5-18(17)22(24,25)26/h1-2,4-9H,3,10-14H2,(H,27,31)(H,29,30)
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n/an/a 16n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310809
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(2-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-15-6-8-16(9-7-15)27-20(31)28-13-3-11-21(14-28,12-10-19(29)30)17-4-1-2-5-18(17)22(24,25)26/h1-2,4-9H,3,10-14H2,(H,27,31)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Epoxide hydrolase 1


(Homo sapiens (Human))
BDBM50310809
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(2-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-15-6-8-16(9-7-15)27-20(31)28-13-3-11-21(14-28,12-10-19(29)30)17-4-1-2-5-18(17)22(24,25)26/h1-2,4-9H,3,10-14H2,(H,27,31)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human microsomal epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50310809
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(2-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-15-6-8-16(9-7-15)27-20(31)28-13-3-11-21(14-28,12-10-19(29)30)17-4-1-2-5-18(17)22(24,25)26/h1-2,4-9H,3,10-14H2,(H,27,31)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50310809
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(2-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-15-6-8-16(9-7-15)27-20(31)28-13-3-11-21(14-28,12-10-19(29)30)17-4-1-2-5-18(17)22(24,25)26/h1-2,4-9H,3,10-14H2,(H,27,31)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50310809
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(2-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-15-6-8-16(9-7-15)27-20(31)28-13-3-11-21(14-28,12-10-19(29)30)17-4-1-2-5-18(17)22(24,25)26/h1-2,4-9H,3,10-14H2,(H,27,31)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
EBifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50310812
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(pyridin-3-yl)pip...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1/C20H22ClN3O3/c21-16-4-6-17(7-5-16)23-19(27)24-12-2-9-20(14-24,10-8-18(25)26)15-3-1-11-22-13-15/h1,3-7,11,13H,2,8-10,12,14H2,(H,23,27)(H,25,26)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310812
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(pyridin-3-yl)pip...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1/C20H22ClN3O3/c21-16-4-6-17(7-5-16)23-19(27)24-12-2-9-20(14-24,10-8-18(25)26)15-3-1-11-22-13-15/h1,3-7,11,13H,2,8-10,12,14H2,(H,23,27)(H,25,26)
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n/an/a 331n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50310812
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(pyridin-3-yl)pip...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1/C20H22ClN3O3/c21-16-4-6-17(7-5-16)23-19(27)24-12-2-9-20(14-24,10-8-18(25)26)15-3-1-11-22-13-15/h1,3-7,11,13H,2,8-10,12,14H2,(H,23,27)(H,25,26)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50310812
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(pyridin-3-yl)pip...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1/C20H22ClN3O3/c21-16-4-6-17(7-5-16)23-19(27)24-12-2-9-20(14-24,10-8-18(25)26)15-3-1-11-22-13-15/h1,3-7,11,13H,2,8-10,12,14H2,(H,23,27)(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50310812
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(pyridin-3-yl)pip...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1/C20H22ClN3O3/c21-16-4-6-17(7-5-16)23-19(27)24-12-2-9-20(14-24,10-8-18(25)26)15-3-1-11-22-13-15/h1,3-7,11,13H,2,8-10,12,14H2,(H,23,27)(H,25,26)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50310812
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(pyridin-3-yl)pip...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1/C20H22ClN3O3/c21-16-4-6-17(7-5-16)23-19(27)24-12-2-9-20(14-24,10-8-18(25)26)15-3-1-11-22-13-15/h1,3-7,11,13H,2,8-10,12,14H2,(H,23,27)(H,25,26)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Nav1.5 channel


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2C8


(Homo sapiens (Human))
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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n/an/a 6.50E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2C8


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50310809
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(2-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-15-6-8-16(9-7-15)27-20(31)28-13-3-11-21(14-28,12-10-19(29)30)17-4-1-2-5-18(17)22(24,25)26/h1-2,4-9H,3,10-14H2,(H,27,31)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Nav1.5 channel


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
EBifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50310816
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(3-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-17-5-7-18(8-6-17)27-20(31)28-12-2-10-21(14-28,11-9-19(29)30)15-3-1-4-16(13-15)22(24,25)26/h1,3-8,13H,2,9-12,14H2,(H,27,31)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310816
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(3-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-17-5-7-18(8-6-17)27-20(31)28-12-2-10-21(14-28,11-9-19(29)30)15-3-1-4-16(13-15)22(24,25)26/h1,3-8,13H,2,9-12,14H2,(H,27,31)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Epoxide hydrolase 1


(Homo sapiens (Human))
BDBM50310816
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(3-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-17-5-7-18(8-6-17)27-20(31)28-12-2-10-21(14-28,11-9-19(29)30)15-3-1-4-16(13-15)22(24,25)26/h1,3-8,13H,2,9-12,14H2,(H,27,31)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human microsomal epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50310816
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(3-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-17-5-7-18(8-6-17)27-20(31)28-12-2-10-21(14-28,11-9-19(29)30)15-3-1-4-16(13-15)22(24,25)26/h1,3-8,13H,2,9-12,14H2,(H,27,31)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50310816
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(3-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-17-5-7-18(8-6-17)27-20(31)28-12-2-10-21(14-28,11-9-19(29)30)15-3-1-4-16(13-15)22(24,25)26/h1,3-8,13H,2,9-12,14H2,(H,27,31)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50310816
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(3-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-17-5-7-18(8-6-17)27-20(31)28-12-2-10-21(14-28,11-9-19(29)30)15-3-1-4-16(13-15)22(24,25)26/h1,3-8,13H,2,9-12,14H2,(H,27,31)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50310816
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-(3-(trifluorometh...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1/C22H22ClF3N2O3/c23-17-5-7-18(8-6-17)27-20(31)28-12-2-10-21(14-28,11-9-19(29)30)15-3-1-4-16(13-15)22(24,25)26/h1,3-8,13H,2,9-12,14H2,(H,27,31)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Nav1.5 channel


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
EBifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50310819
PNG
(2-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C20H21ClN2O3/c21-16-7-9-17(10-8-16)22-19(26)23-12-4-11-20(14-23,13-18(24)25)15-5-2-1-3-6-15/h1-3,5-10H,4,11-14H2,(H,22,26)(H,24,25)
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n/an/a 52n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310819
PNG
(2-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C20H21ClN2O3/c21-16-7-9-17(10-8-16)22-19(26)23-12-4-11-20(14-23,13-18(24)25)15-5-2-1-3-6-15/h1-3,5-10H,4,11-14H2,(H,22,26)(H,24,25)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
EBifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50310819
PNG
(2-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C20H21ClN2O3/c21-16-7-9-17(10-8-16)22-19(26)23-12-4-11-20(14-23,13-18(24)25)15-5-2-1-3-6-15/h1-3,5-10H,4,11-14H2,(H,22,26)(H,24,25)
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n/an/a 3.80E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Epoxide hydrolase 1


(Homo sapiens (Human))
BDBM50310819
PNG
(2-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C20H21ClN2O3/c21-16-7-9-17(10-8-16)22-19(26)23-12-4-11-20(14-23,13-18(24)25)15-5-2-1-3-6-15/h1-3,5-10H,4,11-14H2,(H,22,26)(H,24,25)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human microsomal epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50310819
PNG
(2-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C20H21ClN2O3/c21-16-7-9-17(10-8-16)22-19(26)23-12-4-11-20(14-23,13-18(24)25)15-5-2-1-3-6-15/h1-3,5-10H,4,11-14H2,(H,22,26)(H,24,25)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50310819
PNG
(2-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C20H21ClN2O3/c21-16-7-9-17(10-8-16)22-19(26)23-12-4-11-20(14-23,13-18(24)25)15-5-2-1-3-6-15/h1-3,5-10H,4,11-14H2,(H,22,26)(H,24,25)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50310819
PNG
(2-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C20H21ClN2O3/c21-16-7-9-17(10-8-16)22-19(26)23-12-4-11-20(14-23,13-18(24)25)15-5-2-1-3-6-15/h1-3,5-10H,4,11-14H2,(H,22,26)(H,24,25)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50310819
PNG
(2-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C20H21ClN2O3/c21-16-7-9-17(10-8-16)22-19(26)23-12-4-11-20(14-23,13-18(24)25)15-5-2-1-3-6-15/h1-3,5-10H,4,11-14H2,(H,22,26)(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Nav1.5 channel


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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n/an/a 76n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
EBifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Epoxide hydrolase 1


(Homo sapiens (Human))
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human microsomal epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50310808
PNG
(3-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C21H23ClN2O3/c22-17-7-9-18(10-8-17)23-20(27)24-14-4-12-21(15-24,13-11-19(25)26)16-5-2-1-3-6-16/h1-3,5-10H,4,11-15H2,(H,23,27)(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
EBifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50310820
PNG
(4-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C22H25ClN2O3/c23-18-9-11-19(12-10-18)24-21(28)25-15-5-14-22(16-25,13-4-8-20(26)27)17-6-2-1-3-7-17/h1-3,6-7,9-12H,4-5,8,13-16H2,(H,24,28)(H,26,27)
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n/an/a 12n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310820
PNG
(4-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C22H25ClN2O3/c23-18-9-11-19(12-10-18)24-21(28)25-15-5-14-22(16-25,13-4-8-20(26)27)17-6-2-1-3-7-17/h1-3,6-7,9-12H,4-5,8,13-16H2,(H,24,28)(H,26,27)
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n/an/a 176n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
EBifunctional epoxide hydrolase 2


(Homo sapiens (Human))
BDBM50310820
PNG
(4-(1-(4-chlorophenylcarbamoyl)-3-phenylpiperidin-3...)
Show SMILES OC(=O)CCCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1/C22H25ClN2O3/c23-18-9-11-19(12-10-18)24-21(28)25-15-5-14-22(16-25,13-4-8-20(26)27)17-6-2-1-3-7-17/h1-3,6-7,9-12H,4-5,8,13-16H2,(H,24,28)(H,26,27)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production


Bioorg Med Chem Lett 19: 5314-20 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.138
BindingDB Entry DOI: 10.7270/Q2S75GFP
More data for this
Ligand-Target Pair
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