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4 similar compounds to monomer 50312950

Wt: 339.7
BDBM50312949
Wt: 319.3
BDBM50312951
Wt: 279.2
BDBM50312964
Wt: 305.3
BDBM50312965

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50312949,50312951,50312964,50312965   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A2b


(Homo sapiens (Human))
BDBM50312965
PNG
(CHEMBL1081812 | N-(2-(furan-2-yl)-3,4'-bipyridin-6...)
Show SMILES O=C(Nc1ccc(-c2ccncc2)c(n1)-c1ccco1)C1CC1
Show InChI InChI=1S/C18H15N3O2/c22-18(13-3-4-13)21-16-6-5-14(12-7-9-19-10-8-12)17(20-16)15-2-1-11-23-15/h1-2,5-11,13H,3-4H2,(H,20,21,22)
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1n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))
BDBM50312949
PNG
(CHEMBL1079803 | N-(3'-chloro-2-(furan-2-yl)-3,4'-b...)
Show SMILES Clc1cnccc1-c1ccc(NC(=O)C2CC2)nc1-c1ccco1
Show InChI InChI=1S/C18H14ClN3O2/c19-14-10-20-8-7-12(14)13-5-6-16(22-18(23)11-3-4-11)21-17(13)15-2-1-9-24-15/h1-2,5-11H,3-4H2,(H,21,22,23)
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5n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))
BDBM50312951
PNG
(CHEMBL1082005 | N-(2-(5-methylfuran-2-yl)-3,4'-bip...)
Show SMILES Cc1ccc(o1)-c1nc(NC(=O)C2CC2)ccc1-c1ccncc1
Show InChI InChI=1S/C19H17N3O2/c1-12-2-6-16(24-12)18-15(13-8-10-20-11-9-13)5-7-17(21-18)22-19(23)14-3-4-14/h2,5-11,14H,3-4H2,1H3,(H,21,22,23)
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5n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))
BDBM50312964
PNG
(CHEMBL1081811 | N-(2-(furan-2-yl)-3,4'-bipyridin-6...)
Show SMILES CC(=O)Nc1ccc(-c2ccncc2)c(n1)-c1ccco1
Show InChI InChI=1S/C16H13N3O2/c1-11(20)18-15-5-4-13(12-6-8-17-9-7-12)16(19-15)14-3-2-10-21-14/h2-10H,1H3,(H,18,19,20)
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7n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins by filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50312951
PNG
(CHEMBL1082005 | N-(2-(5-methylfuran-2-yl)-3,4'-bip...)
Show SMILES Cc1ccc(o1)-c1nc(NC(=O)C2CC2)ccc1-c1ccncc1
Show InChI InChI=1S/C19H17N3O2/c1-12-2-6-16(24-12)18-15(13-8-10-20-11-9-13)5-7-17(21-18)22-19(23)14-3-4-14/h2,5-11,14H,3-4H2,1H3,(H,21,22,23)
PDB
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11n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in human HeLa cells after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine Receptor A1


(Homo sapiens (human))
BDBM50312951
PNG
(CHEMBL1082005 | N-(2-(5-methylfuran-2-yl)-3,4'-bip...)
Show SMILES Cc1ccc(o1)-c1nc(NC(=O)C2CC2)ccc1-c1ccncc1
Show InChI InChI=1S/C19H17N3O2/c1-12-2-6-16(24-12)18-15(13-8-10-20-11-9-13)5-7-17(21-18)22-19(23)14-3-4-14/h2,5-11,14H,3-4H2,1H3,(H,21,22,23)
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25n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 90 mins by filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50312965
PNG
(CHEMBL1081812 | N-(2-(furan-2-yl)-3,4'-bipyridin-6...)
Show SMILES O=C(Nc1ccc(-c2ccncc2)c(n1)-c1ccco1)C1CC1
Show InChI InChI=1S/C18H15N3O2/c22-18(13-3-4-13)21-16-6-5-14(12-7-9-19-10-8-12)17(20-16)15-2-1-11-23-15/h1-2,5-11,13H,3-4H2,(H,20,21,22)
PDB
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30n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in human HeLa cells after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine Receptor A1


(Homo sapiens (human))
BDBM50312965
PNG
(CHEMBL1081812 | N-(2-(furan-2-yl)-3,4'-bipyridin-6...)
Show SMILES O=C(Nc1ccc(-c2ccncc2)c(n1)-c1ccco1)C1CC1
Show InChI InChI=1S/C18H15N3O2/c22-18(13-3-4-13)21-16-6-5-14(12-7-9-19-10-8-12)17(20-16)15-2-1-11-23-15/h1-2,5-11,13H,3-4H2,(H,20,21,22)
PDB

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82n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 90 mins by filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50312949
PNG
(CHEMBL1079803 | N-(3'-chloro-2-(furan-2-yl)-3,4'-b...)
Show SMILES Clc1cnccc1-c1ccc(NC(=O)C2CC2)nc1-c1ccco1
Show InChI InChI=1S/C18H14ClN3O2/c19-14-10-20-8-7-12(14)13-5-6-16(22-18(23)11-3-4-11)21-17(13)15-2-1-9-24-15/h1-2,5-11H,3-4H2,(H,21,22,23)
PDB
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147n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in human HeLa cells after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50312951
PNG
(CHEMBL1082005 | N-(2-(5-methylfuran-2-yl)-3,4'-bip...)
Show SMILES Cc1ccc(o1)-c1nc(NC(=O)C2CC2)ccc1-c1ccncc1
Show InChI InChI=1S/C19H17N3O2/c1-12-2-6-16(24-12)18-15(13-8-10-20-11-9-13)5-7-17(21-18)22-19(23)14-3-4-14/h2,5-11,14H,3-4H2,1H3,(H,21,22,23)
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189n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NECA from human adenosine A3 receptor expressed in human HeLa cells after 3 hrs by filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50312964
PNG
(CHEMBL1081811 | N-(2-(furan-2-yl)-3,4'-bipyridin-6...)
Show SMILES CC(=O)Nc1ccc(-c2ccncc2)c(n1)-c1ccco1
Show InChI InChI=1S/C16H13N3O2/c1-11(20)18-15-5-4-13(12-6-8-17-9-7-12)16(19-15)14-3-2-10-21-14/h2-10H,1H3,(H,18,19,20)
PDB
MMDB

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209n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in human HeLa cells after 1 hr by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine Receptor A1


(Homo sapiens (human))
BDBM50312949
PNG
(CHEMBL1079803 | N-(3'-chloro-2-(furan-2-yl)-3,4'-b...)
Show SMILES Clc1cnccc1-c1ccc(NC(=O)C2CC2)nc1-c1ccco1
Show InChI InChI=1S/C18H14ClN3O2/c19-14-10-20-8-7-12(14)13-5-6-16(22-18(23)11-3-4-11)21-17(13)15-2-1-9-24-15/h1-2,5-11H,3-4H2,(H,21,22,23)
PDB

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250n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 90 mins by filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50312964
PNG
(CHEMBL1081811 | N-(2-(furan-2-yl)-3,4'-bipyridin-6...)
Show SMILES CC(=O)Nc1ccc(-c2ccncc2)c(n1)-c1ccco1
Show InChI InChI=1S/C16H13N3O2/c1-11(20)18-15-5-4-13(12-6-8-17-9-7-12)16(19-15)14-3-2-10-21-14/h2-10H,1H3,(H,18,19,20)
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333n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NECA from human adenosine A3 receptor expressed in human HeLa cells after 3 hrs by filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine Receptor A1


(Homo sapiens (human))
BDBM50312964
PNG
(CHEMBL1081811 | N-(2-(furan-2-yl)-3,4'-bipyridin-6...)
Show SMILES CC(=O)Nc1ccc(-c2ccncc2)c(n1)-c1ccco1
Show InChI InChI=1S/C16H13N3O2/c1-11(20)18-15-5-4-13(12-6-8-17-9-7-12)16(19-15)14-3-2-10-21-14/h2-10H,1H3,(H,18,19,20)
PDB

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358n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 90 mins by filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50312965
PNG
(CHEMBL1081812 | N-(2-(furan-2-yl)-3,4'-bipyridin-6...)
Show SMILES O=C(Nc1ccc(-c2ccncc2)c(n1)-c1ccco1)C1CC1
Show InChI InChI=1S/C18H15N3O2/c22-18(13-3-4-13)21-16-6-5-14(12-7-9-19-10-8-12)17(20-16)15-2-1-11-23-15/h1-2,5-11,13H,3-4H2,(H,20,21,22)
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PubMed
1.34E+3n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NECA from human adenosine A3 receptor expressed in human HeLa cells after 3 hrs by filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50312949
PNG
(CHEMBL1079803 | N-(3'-chloro-2-(furan-2-yl)-3,4'-b...)
Show SMILES Clc1cnccc1-c1ccc(NC(=O)C2CC2)nc1-c1ccco1
Show InChI InChI=1S/C18H14ClN3O2/c19-14-10-20-8-7-12(14)13-5-6-16(22-18(23)11-3-4-11)21-17(13)15-2-1-9-24-15/h1-2,5-11H,3-4H2,(H,21,22,23)
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1.87E+3n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Displacement of [3H]NECA from human adenosine A3 receptor expressed in human HeLa cells after 3 hrs by filtration binding assay


Citation and Details
More data for this
Ligand-Target Pair