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18 similar compounds to monomer 50356817

Compile data set for download or QSAR
Wt: 282.3
BDBM50315332
Wt: 336.3
BDBM50315333
Wt: 344.4
BDBM50315334
Wt: 293.3
BDBM50315336
Wt: 351.3
BDBM50356786
Wt: 351.3
BDBM50356788
Wt: 337.2
BDBM50356804
Wt: 337.2
BDBM50356806
Wt: 283.3
BDBM50356810
Wt: 351.3
BDBM50356813
Wt: 362.2
BDBM50356815
Wt: 301.3
BDBM50356816
Wt: 313.3
BDBM50356818
Wt: 351.3
BDBM50356835
Wt: 351.3
BDBM50356837
Displayed 1 to 15 (of 18 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50315332,50315333,50315334,50315336,50356786,50356788,50356804,50356806,50356810,50356813,50356815,50356816,50356818,50356835,50356837   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356815
PNG
(CHEMBL1914781)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(Br)ccc3oc12
Show InChI InChI=1S/C15H16BrN5O/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m1/s1
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PubMed
0.700n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356788
PNG
(CHEMBL1914755)
Show SMILES CN1CCN(CC1)c1nc(N)nc2c3cc(ccc3oc12)C(F)(F)F
Show InChI InChI=1S/C16H16F3N5O/c1-23-4-6-24(7-5-23)14-13-12(21-15(20)22-14)10-8-9(16(17,18)19)2-3-11(10)25-13/h2-3,8H,4-7H2,1H3,(H2,20,21,22)
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0.800n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356816
PNG
(CHEMBL1914782)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(F)ccc3oc12
Show InChI InChI=1S/C15H16FN5O/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m1/s1
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2n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356810
PNG
(CHEMBL1914776)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3ccccc3oc12
Show InChI InChI=1S/C15H17N5O/c1-17-9-6-7-20(8-9)14-13-12(18-15(16)19-14)10-4-2-3-5-11(10)21-13/h2-5,9,17H,6-8H2,1H3,(H2,16,18,19)/t9-/m1/s1
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3.40n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356818
PNG
(CHEMBL1914784)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(OC)ccc3oc12
Show InChI InChI=1S/C16H19N5O2/c1-18-9-5-6-21(8-9)15-14-13(19-16(17)20-15)11-7-10(22-2)3-4-12(11)23-14/h3-4,7,9,18H,5-6,8H2,1-2H3,(H2,17,19,20)/t9-/m1/s1
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11n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356806
PNG
(CHEMBL1914772)
Show SMILES Nc1nc(N2CCNCC2)c2oc3ccc(cc3c2n1)C(F)(F)F
Show InChI InChI=1S/C15H14F3N5O/c16-15(17,18)8-1-2-10-9(7-8)11-12(24-10)13(22-14(19)21-11)23-5-3-20-4-6-23/h1-2,7,20H,3-6H2,(H2,19,21,22)
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13n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356837
PNG
(CHEMBL1915026)
Show SMILES N[C@H]1CCCN(C1)c1nc(N)nc2c1oc1ccc(cc21)C(F)(F)F
Show InChI InChI=1S/C16H16F3N5O/c17-16(18,19)8-3-4-11-10(6-8)12-13(25-11)14(23-15(21)22-12)24-5-1-2-9(20)7-24/h3-4,6,9H,1-2,5,7,20H2,(H2,21,22,23)/t9-/m0/s1
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42n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356786
PNG
(CHEMBL1914753)
Show SMILES CN1CCN(CC1)c1nc(N)nc2c1oc1cccc(c21)C(F)(F)F
Show InChI InChI=1S/C16H16F3N5O/c1-23-5-7-24(8-6-23)14-13-12(21-15(20)22-14)11-9(16(17,18)19)3-2-4-10(11)25-13/h2-4H,5-8H2,1H3,(H2,20,21,22)
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50n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356804
PNG
(CHEMBL1914770)
Show SMILES Nc1nc(N2CCNCC2)c2oc3cccc(c3c2n1)C(F)(F)F
Show InChI InChI=1S/C15H14F3N5O/c16-15(17,18)8-2-1-3-9-10(8)11-12(24-9)13(22-14(19)21-11)23-6-4-20-5-7-23/h1-3,20H,4-7H2,(H2,19,21,22)
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121n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356813
PNG
(CHEMBL1914779)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c1oc1cccc(c21)C(F)(F)F
Show InChI InChI=1S/C16H16F3N5O/c1-21-8-5-6-24(7-8)14-13-12(22-15(20)23-14)11-9(16(17,18)19)3-2-4-10(11)25-13/h2-4,8,21H,5-7H2,1H3,(H2,20,22,23)/t8-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356835
PNG
(CHEMBL1915024)
Show SMILES N[C@H]1CCCN(C1)c1nc(N)nc2c1oc1cccc(c21)C(F)(F)F
Show InChI InChI=1S/C16H16F3N5O/c17-16(18,19)9-4-1-5-10-11(9)12-13(25-10)14(23-15(21)22-12)24-6-2-3-8(20)7-24/h1,4-5,8H,2-3,6-7,20H2,(H2,21,22,23)/t8-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315332
PNG
((R)-N-methyl-1-(8-methylbenzofuro[3,2-d]pyrimidin-...)
Show SMILES CN[C@@H]1CCN(C1)c1ncnc2c1oc1ccc(C)cc21
Show InChI InChI=1S/C16H18N4O/c1-10-3-4-13-12(7-10)14-15(21-13)16(19-9-18-14)20-6-5-11(8-20)17-2/h3-4,7,9,11,17H,5-6,8H2,1-2H3/t11-/m1/s1
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n/an/a 86n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315333
PNG
((R)-N-methyl-1-(8-(trifluoromethyl)benzofuro[3,2-d...)
Show SMILES CN[C@@H]1CCN(C1)c1ncnc2c3cc(ccc3oc12)C(F)(F)F
Show InChI InChI=1S/C16H15F3N4O/c1-20-10-4-5-23(7-10)15-14-13(21-8-22-15)11-6-9(16(17,18)19)2-3-12(11)24-14/h2-3,6,8,10,20H,4-5,7H2,1H3/t10-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315334
PNG
(CHEMBL1089166 | N-methyl-1-(8-phenylbenzofuro[3,2-...)
Show SMILES CNC1CCN(C1)c1ncnc2c1oc1ccc(cc21)-c1ccccc1
Show InChI InChI=1S/C21H20N4O/c1-22-16-9-10-25(12-16)21-20-19(23-13-24-21)17-11-15(7-8-18(17)26-20)14-5-3-2-4-6-14/h2-8,11,13,16,22H,9-10,12H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315336
PNG
(4-(3-(methylamino)pyrrolidin-1-yl)benzofuro[3,2-d]...)
Show SMILES CNC1CCN(C1)c1ncnc2c3cc(ccc3oc12)C#N
Show InChI InChI=1S/C16H15N5O/c1-18-11-4-5-21(8-11)16-15-14(19-9-20-16)12-6-10(7-17)2-3-13(12)22-15/h2-3,6,9,11,18H,4-5,8H2,1H3
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n/an/a 6.20E+3n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair