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9 similar compounds to monomer 50356788

Compile data set for download or QSAR
Wt: 336.3
BDBM50315333
Wt: 269.3
BDBM50356801
Wt: 351.3
BDBM50356786
Wt: 337.2
BDBM50356804
Wt: 337.2
BDBM50356806
Wt: 351.3
BDBM50356813
Wt: 351.3
BDBM50356817
Wt: 351.3
BDBM50356837
Wt: 349.3
BDBM50356845

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50315333,50356801,50356786,50356804,50356806,50356813,50356817,50356837,50356845   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356817
PNG
(CHEMBL1914783)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(ccc3oc12)C(F)(F)F
Show InChI InChI=1S/C16H16F3N5O/c1-21-9-4-5-24(7-9)14-13-12(22-15(20)23-14)10-6-8(16(17,18)19)2-3-11(10)25-13/h2-3,6,9,21H,4-5,7H2,1H3,(H2,20,22,23)/t9-/m1/s1
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PubMed
1n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356806
PNG
(CHEMBL1914772)
Show SMILES Nc1nc(N2CCNCC2)c2oc3ccc(cc3c2n1)C(F)(F)F
Show InChI InChI=1S/C15H14F3N5O/c16-15(17,18)8-1-2-10-9(7-8)11-12(24-10)13(22-14(19)21-11)23-5-3-20-4-6-23/h1-2,7,20H,3-6H2,(H2,19,21,22)
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13n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356801
PNG
(CHEMBL1914767)
Show SMILES Nc1nc(N2CCNCC2)c2oc3ccccc3c2n1
Show InChI InChI=1S/C14H15N5O/c15-14-17-11-9-3-1-2-4-10(9)20-12(11)13(18-14)19-7-5-16-6-8-19/h1-4,16H,5-8H2,(H2,15,17,18)
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21n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356837
PNG
(CHEMBL1915026)
Show SMILES N[C@H]1CCCN(C1)c1nc(N)nc2c1oc1ccc(cc21)C(F)(F)F
Show InChI InChI=1S/C16H16F3N5O/c17-16(18,19)8-3-4-11-10(6-8)12-13(25-11)14(23-15(21)22-12)24-5-1-2-9(20)7-24/h3-4,6,9H,1-2,5,7,20H2,(H2,21,22,23)/t9-/m0/s1
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42n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356786
PNG
(CHEMBL1914753)
Show SMILES CN1CCN(CC1)c1nc(N)nc2c1oc1cccc(c21)C(F)(F)F
Show InChI InChI=1S/C16H16F3N5O/c1-23-5-7-24(8-6-23)14-13-12(21-15(20)22-14)11-9(16(17,18)19)3-2-4-10(11)25-13/h2-4H,5-8H2,1H3,(H2,20,21,22)
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50n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356804
PNG
(CHEMBL1914770)
Show SMILES Nc1nc(N2CCNCC2)c2oc3cccc(c3c2n1)C(F)(F)F
Show InChI InChI=1S/C15H14F3N5O/c16-15(17,18)8-2-1-3-9-10(8)11-12(24-9)13(22-14(19)21-11)23-6-4-20-5-7-23/h1-3,20H,4-7H2,(H2,19,21,22)
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121n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356845
PNG
(CHEMBL1915034)
Show SMILES Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2oc3ccc(cc3c2n1)C(F)(F)F
Show InChI InChI=1S/C16H14F3N5O/c17-16(18,19)7-1-2-11-10(3-7)12-13(25-11)14(23-15(20)22-12)24-6-8-4-9(24)5-21-8/h1-3,8-9,21H,4-6H2,(H2,20,22,23)/t8-,9-/m0/s1
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272n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356813
PNG
(CHEMBL1914779)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c1oc1cccc(c21)C(F)(F)F
Show InChI InChI=1S/C16H16F3N5O/c1-21-8-5-6-24(7-8)14-13-12(22-15(20)23-14)11-9(16(17,18)19)3-2-4-10(11)25-13/h2-4,8,21H,5-7H2,1H3,(H2,20,22,23)/t8-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50315333
PNG
((R)-N-methyl-1-(8-(trifluoromethyl)benzofuro[3,2-d...)
Show SMILES CN[C@@H]1CCN(C1)c1ncnc2c3cc(ccc3oc12)C(F)(F)F
Show InChI InChI=1S/C16H15F3N4O/c1-20-10-4-5-23(7-10)15-14-13(21-8-22-15)11-6-9(16(17,18)19)2-3-12(11)24-14/h2-3,6,8,10,20H,4-5,7H2,1H3/t10-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assay


Bioorg Med Chem Lett 20: 2516-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.097
BindingDB Entry DOI: 10.7270/Q2CN74V3
More data for this
Ligand-Target Pair