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5 similar compounds to monomer 50316780

Compile data set for download or QSAR
Wt: 498.6
BDBM50316781
Wt: 536.6
BDBM50316782
Wt: 440.5
BDBM50316784
Wt: 468.6
BDBM50316788
Wt: 542.5
BDBM50316783

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50316781,50316782,50316784,50316788,50316783   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 1.20n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 250 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 1n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of EGFR after 30 mins by chemiluminescence ELISA in presence of 250 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50316784
PNG
(4-(2-(3-Amino-9-(3-phenylpropyl)-2,3,4,9-tetrahydr...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c30-23-10-14-28-26(19-23)27-20-25(33-18-16-22-8-11-24(32)12-9-22)13-15-29(27)31(28)17-4-7-21-5-2-1-3-6-21/h1-3,5-6,8-9,11-13,15,20,23,32H,4,7,10,14,16-19,30H2
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n/an/a 2.90n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 2.20n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA in presence of 250 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 1n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of EGFR after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 2.20n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 1.10n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 1n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 250 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 2.10n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 1.06E+3n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 0.980n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of EGFR after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 2.17E+3n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 1.01E+3n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 930n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of IGF1R after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50316783
PNG
(4-(2-(3-Amino-9-(5-(pyridine-2-yl)pentyl)-2,3,4,9-...)
Show SMILES Cl.Cl.NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccn1
Show InChI InChI=1S/C30H35N3O2/c31-23-10-14-29-27(20-23)28-21-26(35-19-16-22-8-11-25(34)12-9-22)13-15-30(28)33(29)18-5-1-2-6-24-7-3-4-17-32-24/h3-4,7-9,11-13,15,17,21,23,34H,1-2,5-6,10,14,16,18-20,31H2
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n/an/a 2.20n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50316781
PNG
(4-(2-(3-Amino-9-(5-(4-methoxyphenyl)pentyl)-2,3,4,...)
Show SMILES COc1ccc(CCCCCn2c3CCC(N)Cc3c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C32H38N2O3/c1-36-27-13-8-23(9-14-27)5-3-2-4-19-34-31-16-10-25(33)21-29(31)30-22-28(15-17-32(30)34)37-20-18-24-6-11-26(35)12-7-24/h6-9,11-15,17,22,25,35H,2-5,10,16,18-21,33H2,1H3
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n/an/a 1.80n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50316782
PNG
(4-(2-(3-Amino-9-(5-(4-(trifluoromethyl)phenyl)pent...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C32H35F3N2O2/c33-32(34,35)24-9-5-22(6-10-24)4-2-1-3-18-37-30-15-11-25(36)20-28(30)29-21-27(14-16-31(29)37)39-19-17-23-7-12-26(38)13-8-23/h5-10,12-14,16,21,25,38H,1-4,11,15,17-20,36H2
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n/an/a 2.30n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50316781
PNG
(4-(2-(3-Amino-9-(5-(4-methoxyphenyl)pentyl)-2,3,4,...)
Show SMILES COc1ccc(CCCCCn2c3CCC(N)Cc3c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C32H38N2O3/c1-36-27-13-8-23(9-14-27)5-3-2-4-19-34-31-16-10-25(33)21-29(31)30-22-28(15-17-32(30)34)37-20-18-24-6-11-26(35)12-7-24/h6-9,11-15,17,22,25,35H,2-5,10,16,18-21,33H2,1H3
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n/an/a 1.40n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50316782
PNG
(4-(2-(3-Amino-9-(5-(4-(trifluoromethyl)phenyl)pent...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C32H35F3N2O2/c33-32(34,35)24-9-5-22(6-10-24)4-2-1-3-18-37-30-15-11-25(36)20-28(30)29-21-27(14-16-31(29)37)39-19-17-23-7-12-26(38)13-8-23/h5-10,12-14,16,21,25,38H,1-4,11,15,17-20,36H2
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n/an/a 2.80n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50316783
PNG
(4-(2-(3-Amino-9-(5-(pyridine-2-yl)pentyl)-2,3,4,9-...)
Show SMILES Cl.Cl.NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccn1
Show InChI InChI=1S/C30H35N3O2/c31-23-10-14-29-27(20-23)28-21-26(35-19-16-22-8-11-25(34)12-9-22)13-15-30(28)33(29)18-5-1-2-6-24-7-3-4-17-32-24/h3-4,7-9,11-13,15,17,21,23,34H,1-2,5-6,10,14,16,18-20,31H2
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n/an/a 2.30n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50316784
PNG
(4-(2-(3-Amino-9-(3-phenylpropyl)-2,3,4,9-tetrahydr...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c30-23-10-14-28-26(19-23)27-20-25(33-18-16-22-8-11-24(32)12-9-22)13-15-29(27)31(28)17-4-7-21-5-2-1-3-6-21/h1-3,5-6,8-9,11-13,15,20,23,32H,4,7,10,14,16-19,30H2
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n/an/a 2.5n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 30 mins by chemiluminescence ELISA


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50316781
PNG
(4-(2-(3-Amino-9-(5-(4-methoxyphenyl)pentyl)-2,3,4,...)
Show SMILES COc1ccc(CCCCCn2c3CCC(N)Cc3c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C32H38N2O3/c1-36-27-13-8-23(9-14-27)5-3-2-4-19-34-31-16-10-25(33)21-29(31)30-22-28(15-17-32(30)34)37-20-18-24-6-11-26(35)12-7-24/h6-9,11-15,17,22,25,35H,2-5,10,16,18-21,33H2,1H3
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n/an/a 2.90n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50316782
PNG
(4-(2-(3-Amino-9-(5-(4-(trifluoromethyl)phenyl)pent...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C32H35F3N2O2/c33-32(34,35)24-9-5-22(6-10-24)4-2-1-3-18-37-30-15-11-25(36)20-28(30)29-21-27(14-16-31(29)37)39-19-17-23-7-12-26(38)13-8-23/h5-10,12-14,16,21,25,38H,1-4,11,15,17-20,36H2
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n/an/a 5.20n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50316783
PNG
(4-(2-(3-Amino-9-(5-(pyridine-2-yl)pentyl)-2,3,4,9-...)
Show SMILES Cl.Cl.NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccn1
Show InChI InChI=1S/C30H35N3O2/c31-23-10-14-29-27(20-23)28-21-26(35-19-16-22-8-11-25(34)12-9-22)13-15-30(28)33(29)18-5-1-2-6-24-7-3-4-17-32-24/h3-4,7-9,11-13,15,17,21,23,34H,1-2,5-6,10,14,16,18-20,31H2
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n/an/a 2.80n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50316784
PNG
(4-(2-(3-Amino-9-(3-phenylpropyl)-2,3,4,9-tetrahydr...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c30-23-10-14-28-26(19-23)27-20-25(33-18-16-22-8-11-24(32)12-9-22)13-15-29(27)31(28)17-4-7-21-5-2-1-3-6-21/h1-3,5-6,8-9,11-13,15,20,23,32H,4,7,10,14,16-19,30H2
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n/an/a 1.30n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50316781
PNG
(4-(2-(3-Amino-9-(5-(4-methoxyphenyl)pentyl)-2,3,4,...)
Show SMILES COc1ccc(CCCCCn2c3CCC(N)Cc3c3cc(OCCc4ccc(O)cc4)ccc23)cc1
Show InChI InChI=1S/C32H38N2O3/c1-36-27-13-8-23(9-14-27)5-3-2-4-19-34-31-16-10-25(33)21-29(31)30-22-28(15-17-32(30)34)37-20-18-24-6-11-26(35)12-7-24/h6-9,11-15,17,22,25,35H,2-5,10,16,18-21,33H2,1H3
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n/an/a 0.940n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50316782
PNG
(4-(2-(3-Amino-9-(5-(4-(trifluoromethyl)phenyl)pent...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C32H35F3N2O2/c33-32(34,35)24-9-5-22(6-10-24)4-2-1-3-18-37-30-15-11-25(36)20-28(30)29-21-27(14-16-31(29)37)39-19-17-23-7-12-26(38)13-8-23/h5-10,12-14,16,21,25,38H,1-4,11,15,17-20,36H2
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n/an/a 2.20n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50316783
PNG
(4-(2-(3-Amino-9-(5-(pyridine-2-yl)pentyl)-2,3,4,9-...)
Show SMILES Cl.Cl.NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccn1
Show InChI InChI=1S/C30H35N3O2/c31-23-10-14-29-27(20-23)28-21-26(35-19-16-22-8-11-25(34)12-9-22)13-15-30(28)33(29)18-5-1-2-6-24-7-3-4-17-32-24/h3-4,7-9,11-13,15,17,21,23,34H,1-2,5-6,10,14,16,18-20,31H2
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n/an/a 2.10n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50316784
PNG
(4-(2-(3-Amino-9-(3-phenylpropyl)-2,3,4,9-tetrahydr...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCc1ccccc1
Show InChI InChI=1S/C29H32N2O2/c30-23-10-14-28-26(19-23)27-20-25(33-18-16-22-8-11-24(32)12-9-22)13-15-29(27)31(28)17-4-7-21-5-2-1-3-6-21/h1-3,5-6,8-9,11-13,15,20,23,32H,4,7,10,14,16-19,30H2
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n/an/a 2.10n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 0.930n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 1.10n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50316788
PNG
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)
Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1
Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2
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n/an/a 0.990n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP


Bioorg Med Chem 18: 3387-402 (2010)


Article DOI: 10.1016/j.bmc.2010.04.001
BindingDB Entry DOI: 10.7270/Q21836NT
More data for this
Ligand-Target Pair