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22 similar compounds to monomer 50318312

Compile data set for download or QSAR
Wt: 263.3
BDBM50318332
Wt: 262.3
BDBM50318333
Wt: 262.3
BDBM50318334
Wt: 262.3
BDBM50318335
Wt: 275.3
BDBM50318342
Wt: 233.3
BDBM50318343
Wt: 219.2
BDBM50318344
Wt: 261.3
BDBM50318315
Wt: 261.3
BDBM50318316
Wt: 261.3
BDBM50318317
Wt: 265.3
BDBM50318318
Wt: 265.3
BDBM50318319
Wt: 265.3
BDBM50318320
Wt: 281.7
BDBM50318321
Wt: 281.7
BDBM50318322
Displayed 1 to 15 (of 22 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50318332,50318333,50318334,50318335,50318342,50318343,50318344,50318315,50318316,50318317,50318318,50318319,50318320,50318321,50318322   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318315
PNG
(5-hexyl-3-o-tolyloxazolidin-2-one | CHEMBL1096081)
Show SMILES CCCCCCC1CN(C(=O)O1)c1ccccc1C
Show InChI InChI=1/C16H23NO2/c1-3-4-5-6-10-14-12-17(16(18)19-14)15-11-8-7-9-13(15)2/h7-9,11,14H,3-6,10,12H2,1-2H3
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PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318344
PNG
(5-butyl-3-phenyloxazolidin-2-one | CHEMBL1095703)
Show SMILES CCCCC1CN(C(=O)O1)c1ccccc1
Show InChI InChI=1/C13H17NO2/c1-2-3-9-12-10-14(13(15)16-12)11-7-5-4-6-8-11/h4-8,12H,2-3,9-10H2,1H3
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n/an/an/an/a 1.30E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318317
PNG
(5-hexyl-3-p-tolyloxazolidin-2-one | CHEMBL1095638)
Show SMILES CCCCCCC1CN(C(=O)O1)c1ccc(C)cc1
Show InChI InChI=1/C16H23NO2/c1-3-4-5-6-7-15-12-17(16(18)19-15)14-10-8-13(2)9-11-14/h8-11,15H,3-7,12H2,1-2H3
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n/an/an/an/a 3.82E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318318
PNG
(3-(2-fluorophenyl)-5-hexyloxazolidin-2-one | CHEMB...)
Show SMILES CCCCCCC1CN(C(=O)O1)c1ccccc1F
Show InChI InChI=1/C15H20FNO2/c1-2-3-4-5-8-12-11-17(15(18)19-12)14-10-7-6-9-13(14)16/h6-7,9-10,12H,2-5,8,11H2,1H3
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PubMed
n/an/an/an/a 7.15E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318319
PNG
(3-(3-fluorophenyl)-5-hexyloxazolidin-2-one | CHEMB...)
Show SMILES CCCCCCC1CN(C(=O)O1)c1cccc(F)c1
Show InChI InChI=1/C15H20FNO2/c1-2-3-4-5-9-14-11-17(15(18)19-14)13-8-6-7-12(16)10-13/h6-8,10,14H,2-5,9,11H2,1H3
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PubMed
n/an/an/an/a 640n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318320
PNG
(3-(4-fluorophenyl)-5-hexyloxazolidin-2-one | CHEMB...)
Show SMILES CCCCCCC1CN(C(=O)O1)c1ccc(F)cc1
Show InChI InChI=1/C15H20FNO2/c1-2-3-4-5-6-14-11-17(15(18)19-14)13-9-7-12(16)8-10-13/h7-10,14H,2-6,11H2,1H3
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PubMed
n/an/an/an/a 790n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318321
PNG
(3-(2-chlorophenyl)-5-hexyloxazolidin-2-one | CHEMB...)
Show SMILES CCCCCCC1CN(C(=O)O1)c1ccccc1Cl
Show InChI InChI=1/C15H20ClNO2/c1-2-3-4-5-8-12-11-17(15(18)19-12)14-10-7-6-9-13(14)16/h6-7,9-10,12H,2-5,8,11H2,1H3
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PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318322
PNG
(3-(3-chlorophenyl)-5-hexyloxazolidin-2-one | CHEMB...)
Show SMILES CCCCCCC1CN(C(=O)O1)c1cccc(Cl)c1
Show InChI InChI=1/C15H20ClNO2/c1-2-3-4-5-9-14-11-17(15(18)19-14)13-8-6-7-12(16)10-13/h6-8,10,14H,2-5,9,11H2,1H3
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n/an/an/an/a 590n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318332
PNG
(5-hexyl-3-(4-hydroxyphenyl)oxazolidin-2-one | CHEM...)
Show SMILES CCCCCCC1CN(C(=O)O1)c1ccc(O)cc1
Show InChI InChI=1/C15H21NO3/c1-2-3-4-5-6-14-11-16(15(18)19-14)12-7-9-13(17)10-8-12/h7-10,14,17H,2-6,11H2,1H3
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PubMed
n/an/an/an/a 7.81E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318333
PNG
(3-(2-aminophenyl)-5-hexyloxazolidin-2-one | CHEMBL...)
Show SMILES CCCCCCC1CN(C(=O)O1)c1ccccc1N
Show InChI InChI=1/C15H22N2O2/c1-2-3-4-5-8-12-11-17(15(18)19-12)14-10-7-6-9-13(14)16/h6-7,9-10,12H,2-5,8,11,16H2,1H3
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PubMed
n/an/an/an/a>3.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318334
PNG
(3-(3-aminophenyl)-5-hexyloxazolidin-2-one | CHEMBL...)
Show SMILES CCCCCCC1CN(C(=O)O1)c1cccc(N)c1
Show InChI InChI=1/C15H22N2O2/c1-2-3-4-5-9-14-11-17(15(18)19-14)13-8-6-7-12(16)10-13/h6-8,10,14H,2-5,9,11,16H2,1H3
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PubMed
n/an/an/an/a 3.30E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318335
PNG
(3-(4-aminophenyl)-5-hexyloxazolidin-2-one | CHEMBL...)
Show SMILES CCCCCCC1CN(C(=O)O1)c1ccc(N)cc1
Show InChI InChI=1/C15H22N2O2/c1-2-3-4-5-6-14-11-17(15(18)19-14)13-9-7-12(16)8-10-13/h7-10,14H,2-6,11,16H2,1H3
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PubMed
n/an/an/an/a 5.87E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318342
PNG
(5-octyl-3-phenyloxazolidin-2-one | CHEMBL1095701)
Show SMILES CCCCCCCCC1CN(C(=O)O1)c1ccccc1
Show InChI InChI=1/C17H25NO2/c1-2-3-4-5-6-10-13-16-14-18(17(19)20-16)15-11-8-7-9-12-15/h7-9,11-12,16H,2-6,10,13-14H2,1H3
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PubMed
n/an/an/an/a 1.20E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318343
PNG
(5-pentyl-3-phenyloxazolidin-2-one | CHEMBL1095702)
Show SMILES CCCCCC1CN(C(=O)O1)c1ccccc1
Show InChI InChI=1/C14H19NO2/c1-2-3-5-10-13-11-15(14(16)17-13)12-8-6-4-7-9-12/h4,6-9,13H,2-3,5,10-11H2,1H3
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PubMed
n/an/an/an/a 790n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50318316
PNG
(5-hexyl-3-m-tolyloxazolidin-2-one | CHEMBL1096423)
Show SMILES CCCCCCC1CN(C(=O)O1)c1cccc(C)c1
Show InChI InChI=1/C16H23NO2/c1-3-4-5-6-10-15-12-17(16(18)19-15)14-9-7-8-13(2)11-14/h7-9,11,15H,3-6,10,12H2,1-2H3
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PubMed
n/an/an/an/a 640n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calc...


Bioorg Med Chem Lett 20: 3129-33 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.089
BindingDB Entry DOI: 10.7270/Q2Z038B7
More data for this
Ligand-Target Pair