BindingDB logo
myBDB logout

5 similar compounds to monomer 50319295

Compile data set for download or QSAR
Wt: 396.5
BDBM50319277
Wt: 404.4
BDBM50319296
Wt: 416.4
BDBM50319298
Wt: 405.4
BDBM50319299
Wt: 410.5
BDBM50319307

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50319277,50319296,50319298,50319299,50319307   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50319277
PNG
(5-fluoro-4-methyl-2-(2-methyl-4-(3-(4-methylpipera...)
Show SMILES CN1CCN(CCCOc2ccc(-c3nc4ccc(F)c(C)c4[nH]3)c(C)c2)CC1
Show InChI InChI=1S/C23H29FN4O/c1-16-15-18(29-14-4-9-28-12-10-27(3)11-13-28)5-6-19(16)23-25-21-8-7-20(24)17(2)22(21)26-23/h5-8,15H,4,9-14H2,1-3H3,(H,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
32n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 20: 3367-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.017
BindingDB Entry DOI: 10.7270/Q23J3D4Z
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50319298
PNG
(2-(4-(3-(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)propoxy...)
Show SMILES Cc1cc(OCCCN2Cc3cccnc3C2)ccc1-c1nc2ccc(F)c(C)c2[nH]1
Show InChI InChI=1S/C25H25FN4O/c1-16-13-19(31-12-4-11-30-14-18-5-3-10-27-23(18)15-30)6-7-20(16)25-28-22-9-8-21(26)17(2)24(22)29-25/h3,5-10,13H,4,11-12,14-15H2,1-2H3,(H,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
228n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 20: 3367-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.017
BindingDB Entry DOI: 10.7270/Q23J3D4Z
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50319299
PNG
(3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-2-yl)-...)
Show SMILES Cc1cc(OCCCNCc2cnccn2)ccc1-c1nc2ccc(F)c(C)c2[nH]1
Show InChI InChI=1S/C23H24FN5O/c1-15-12-18(30-11-3-8-25-13-17-14-26-9-10-27-17)4-5-19(15)23-28-21-7-6-20(24)16(2)22(21)29-23/h4-7,9-10,12,14,25H,3,8,11,13H2,1-2H3,(H,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 20: 3367-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.017
BindingDB Entry DOI: 10.7270/Q23J3D4Z
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50319296
PNG
(3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-2-yl)-...)
Show SMILES Cc1cc(OCCCNCc2ccccn2)ccc1-c1nc2ccc(F)c(C)c2[nH]1
Show InChI InChI=1S/C24H25FN4O/c1-16-14-19(30-13-5-11-26-15-18-6-3-4-12-27-18)7-8-20(16)24-28-22-10-9-21(25)17(2)23(22)29-24/h3-4,6-10,12,14,26H,5,11,13,15H2,1-2H3,(H,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 20: 3367-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.017
BindingDB Entry DOI: 10.7270/Q23J3D4Z
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50319307
PNG
((+/-)-3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-...)
Show SMILES Cc1cc(OCCCNCC2CCCNC2)ccc1-c1nc2ccc(F)c(C)c2[nH]1
Show InChI InChI=1S/C24H31FN4O/c1-16-13-19(30-12-4-11-27-15-18-5-3-10-26-14-18)6-7-20(16)24-28-22-9-8-21(25)17(2)23(22)29-24/h6-9,13,18,26-27H,3-5,10-12,14-15H2,1-2H3,(H,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.90n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forsko...


Bioorg Med Chem Lett 20: 3367-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.017
BindingDB Entry DOI: 10.7270/Q23J3D4Z
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50319277
PNG
(5-fluoro-4-methyl-2-(2-methyl-4-(3-(4-methylpipera...)
Show SMILES CN1CCN(CCCOc2ccc(-c3nc4ccc(F)c(C)c4[nH]3)c(C)c2)CC1
Show InChI InChI=1S/C23H29FN4O/c1-16-15-18(29-14-4-9-28-12-10-27(3)11-13-28)5-6-19(16)23-25-21-8-7-20(24)17(2)22(21)26-23/h5-8,15H,4,9-14H2,1-3H3,(H,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 50n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forsko...


Bioorg Med Chem Lett 20: 3367-71 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.017
BindingDB Entry DOI: 10.7270/Q23J3D4Z
More data for this
Ligand-Target Pair