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5 similar compounds to monomer 50327391

Compile data set for download or QSAR
Wt: 330.8
BDBM50327411
Wt: 345.8
BDBM50327412
Wt: 373.9
BDBM50327413
Wt: 389.9
BDBM50327414
Wt: 419.9
BDBM50327415

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50327411,50327412,50327413,50327414,50327415   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50327411
PNG
(5-(6-(2-chlorophenyl)pyrimidin-4-yl)-N-isopropylth...)
Show SMILES CC(C)Nc1ncc(s1)-c1cc(ncn1)-c1ccccc1Cl
Show InChI InChI=1S/C16H15ClN4S/c1-10(2)21-16-18-8-15(22-16)14-7-13(19-9-20-14)11-5-3-4-6-12(11)17/h3-10H,1-2H3,(H,18,21)
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Article
PubMed
n/an/a 46n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation counting


Bioorg Med Chem Lett 20: 5864-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.102
BindingDB Entry DOI: 10.7270/Q22F7NP6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50327412
PNG
(5-(2-amino-6-(2-chlorophenyl)pyrimidin-4-yl)-N-iso...)
Show SMILES CC(C)Nc1ncc(s1)-c1cc(nc(N)n1)-c1ccccc1Cl
Show InChI InChI=1S/C16H16ClN5S/c1-9(2)20-16-19-8-14(23-16)13-7-12(21-15(18)22-13)10-5-3-4-6-11(10)17/h3-9H,1-2H3,(H,19,20)(H2,18,21,22)
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Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation counting


Bioorg Med Chem Lett 20: 5864-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.102
BindingDB Entry DOI: 10.7270/Q22F7NP6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50327415
PNG
(3-(4-(2-chlorophenyl)-6-(2-(isopropylamino)thiazol...)
Show SMILES CC(C)Nc1ncc(s1)-c1cc(nc(NCC(O)CO)n1)-c1ccccc1Cl
Show InChI InChI=1S/C19H22ClN5O2S/c1-11(2)23-19-22-9-17(28-19)16-7-15(13-5-3-4-6-14(13)20)24-18(25-16)21-8-12(27)10-26/h3-7,9,11-12,26-27H,8,10H2,1-2H3,(H,22,23)(H,21,24,25)
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Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation counting


Bioorg Med Chem Lett 20: 5864-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.102
BindingDB Entry DOI: 10.7270/Q22F7NP6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50327414
PNG
(2-(4-(2-chlorophenyl)-6-(2-(isopropylamino)thiazol...)
Show SMILES CC(C)Nc1ncc(s1)-c1cc(nc(NCCO)n1)-c1ccccc1Cl
Show InChI InChI=1S/C18H20ClN5OS/c1-11(2)22-18-21-10-16(26-18)15-9-14(12-5-3-4-6-13(12)19)23-17(24-15)20-7-8-25/h3-6,9-11,25H,7-8H2,1-2H3,(H,21,22)(H,20,23,24)
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Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation counting


Bioorg Med Chem Lett 20: 5864-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.102
BindingDB Entry DOI: 10.7270/Q22F7NP6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50327413
PNG
(5-(6-(2-chlorophenyl)-2-(dimethylamino)pyrimidin-4...)
Show SMILES CC(C)Nc1ncc(s1)-c1cc(nc(n1)N(C)C)-c1ccccc1Cl
Show InChI InChI=1S/C18H20ClN5S/c1-11(2)21-18-20-10-16(25-18)15-9-14(22-17(23-15)24(3)4)12-7-5-6-8-13(12)19/h5-11H,1-4H3,(H,20,21)
PDB
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Article
PubMed
n/an/a 573n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation counting


Bioorg Med Chem Lett 20: 5864-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.102
BindingDB Entry DOI: 10.7270/Q22F7NP6
More data for this
Ligand-Target Pair