BindingDB logo
myBDB logout

6 similar compounds to monomer 50327451

Wt: 475.5
BDBM50327452
Wt: 477.5
BDBM50327453
Wt: 489.5
BDBM50327454
Wt: 476.5
BDBM50327455
Wt: 532.6
BDBM50327456
Wt: 490.6
BDBM50327457

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50327452,50327453,50327454,50327455,50327456,50327457   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50327452
PNG
(1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...)
Show SMILES CC(=NNC(=S)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc3CCCc3c2)c1=O
Show InChI InChI=1S/C25H25N5O3S/c1-14(26-27-25(34)29-11-10-18-12-19(24(32)33)7-9-21(18)29)22-15(2)28-30(23(22)31)20-8-6-16-4-3-5-17(16)13-20/h6-9,12-13,28H,3-5,10-11H2,1-2H3,(H,27,34)(H,32,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 3n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50327453
PNG
(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)
Show SMILES CC(=NNC(=S)N1CCCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O
Show InChI InChI=1S/C25H27N5O3S/c1-14-7-9-20(12-15(14)2)30-23(31)22(17(4)28-30)16(3)26-27-25(34)29-11-5-6-18-13-19(24(32)33)8-10-21(18)29/h7-10,12-13,28H,5-6,11H2,1-4H3,(H,27,34)(H,32,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 64n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50327457
PNG
(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)
Show SMILES CCNC(=O)c1ccc2N(CCc2c1)C(=S)NN=C(C)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O
Show InChI InChI=1S/C26H30N6O2S/c1-6-27-24(33)20-8-10-22-19(14-20)11-12-31(22)26(35)29-28-17(4)23-18(5)30-32(25(23)34)21-9-7-15(2)16(3)13-21/h7-10,13-14,30H,6,11-12H2,1-5H3,(H,27,33)(H,29,35)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 26n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50327455
PNG
(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)
Show SMILES CNC(=O)c1ccc2N(CCc2c1)C(=S)NN=C(C)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O
Show InChI InChI=1S/C25H28N6O2S/c1-14-6-8-20(12-15(14)2)31-24(33)22(17(4)29-31)16(3)27-28-25(34)30-11-10-18-13-19(23(32)26-5)7-9-21(18)30/h6-9,12-13,29H,10-11H2,1-5H3,(H,26,32)(H,28,34)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 22n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50327456
PNG
(CHEMBL1257847 | N'-(1-(1-(3,4-dimethylphenyl)-3-me...)
Show SMILES CC(=NNC(=S)N1CCc2cc(ccc12)C(=O)N1CCOCC1)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O
Show InChI InChI=1S/C28H32N6O3S/c1-17-5-7-23(15-18(17)2)34-27(36)25(20(4)31-34)19(3)29-30-28(38)33-10-9-21-16-22(6-8-24(21)33)26(35)32-11-13-37-14-12-32/h5-8,15-16,31H,9-14H2,1-4H3,(H,30,38)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 31n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50327454
PNG
(1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...)
Show SMILES CC(=NNC(=S)N1CCCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc3CCCc3c2)c1=O
Show InChI InChI=1S/C26H27N5O3S/c1-15(23-16(2)29-31(24(23)32)21-10-8-17-5-3-6-18(17)14-21)27-28-26(35)30-12-4-7-19-13-20(25(33)34)9-11-22(19)30/h8-11,13-14,29H,3-7,12H2,1-2H3,(H,28,35)(H,33,34)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 35n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair