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9 similar compounds to monomer 50328486

Wt: 387.5
BDBM50328487
Wt: 388.5
BDBM50328488
Wt: 386.5
BDBM50328489
Wt: 400.5
BDBM50328490
Wt: 400.5
BDBM50328491
Wt: 400.5
BDBM50328492
Wt: 414.6
BDBM50328493
Wt: 414.6
BDBM50328494
Wt: 428.6
BDBM50328495

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50328487,50328488,50328489,50328490,50328491,50328492,50328493,50328494,50328495   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ADRA1B


(C.H.O.)
BDBM50328488
PNG
(5-(11-(4-Methylpiperazin-1-yl)-10,11-dihydrodibenz...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1cncnc1
Show InChI InChI=1S/C23H24N4S/c1-26-8-10-27(11-9-26)21-13-18-4-2-3-5-22(18)28-23-7-6-17(12-20(21)23)19-14-24-16-25-15-19/h2-7,12,14-16,21H,8-11,13H2,1H3
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PubMed
0.170n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from hamster cloned alpha1b receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50328488
PNG
(5-(11-(4-Methylpiperazin-1-yl)-10,11-dihydrodibenz...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1cncnc1
Show InChI InChI=1S/C23H24N4S/c1-26-8-10-27(11-9-26)21-13-18-4-2-3-5-22(18)28-23-7-6-17(12-20(21)23)19-14-24-16-25-15-19/h2-7,12,14-16,21H,8-11,13H2,1H3
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0.200n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from bovine cloned alpha1a receptor expressed in BHK cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50328488
PNG
(5-(11-(4-Methylpiperazin-1-yl)-10,11-dihydrodibenz...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1cncnc1
Show InChI InChI=1S/C23H24N4S/c1-26-8-10-27(11-9-26)21-13-18-4-2-3-5-22(18)28-23-7-6-17(12-20(21)23)19-14-24-16-25-15-19/h2-7,12,14-16,21H,8-11,13H2,1H3
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0.240n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from rat cloned alpha1d receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
ADRA1B


(C.H.O.)
BDBM50328489
PNG
(1-Methyl-4-(8-phenyl-10,11-dihydrodibenzo[b,f]thie...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C25H26N2S/c1-26-13-15-27(16-14-26)23-18-21-9-5-6-10-24(21)28-25-12-11-20(17-22(23)25)19-7-3-2-4-8-19/h2-12,17,23H,13-16,18H2,1H3
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0.400n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from hamster cloned alpha1b receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50328489
PNG
(1-Methyl-4-(8-phenyl-10,11-dihydrodibenzo[b,f]thie...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C25H26N2S/c1-26-13-15-27(16-14-26)23-18-21-9-5-6-10-24(21)28-25-12-11-20(17-22(23)25)19-7-3-2-4-8-19/h2-12,17,23H,13-16,18H2,1H3
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0.5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from bovine cloned alpha1a receptor expressed in BHK cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50328487
PNG
(1-Methyl-4-(8-(pyridin-4-yl)-10,11-dihydrodibenzo[...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccncc1
Show InChI InChI=1S/C24H25N3S/c1-26-12-14-27(15-13-26)22-17-20-4-2-3-5-23(20)28-24-7-6-19(16-21(22)24)18-8-10-25-11-9-18/h2-11,16,22H,12-15,17H2,1H3
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0.660n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from rat cloned alpha1d receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50328488
PNG
(5-(11-(4-Methylpiperazin-1-yl)-10,11-dihydrodibenz...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1cncnc1
Show InChI InChI=1S/C23H24N4S/c1-26-8-10-27(11-9-26)21-13-18-4-2-3-5-22(18)28-23-7-6-17(12-20(21)23)19-14-24-16-25-15-19/h2-7,12,14-16,21H,8-11,13H2,1H3
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0.730n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
ADRA1B


(C.H.O.)
BDBM50328492
PNG
(1-Methyl-4-(8-p-tolyl-10,11-dihydrodibenzo[b,f]thi...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C26H28N2S/c1-19-7-9-20(10-8-19)21-11-12-26-23(17-21)24(28-15-13-27(2)14-16-28)18-22-5-3-4-6-25(22)29-26/h3-12,17,24H,13-16,18H2,1-2H3
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0.820n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from hamster cloned alpha1b receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50328490
PNG
(1-Methyl-4-(8-o-tolyl-10,11-dihydrodibenzo[b,f]thi...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccccc1C
Show InChI InChI=1S/C26H28N2S/c1-19-7-3-5-9-22(19)20-11-12-26-23(17-20)24(28-15-13-27(2)14-16-28)18-21-8-4-6-10-25(21)29-26/h3-12,17,24H,13-16,18H2,1-2H3
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0.870n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from bovine cloned alpha1a receptor expressed in BHK cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50328491
PNG
(1-Methyl-4-(8-m-tolyl-10,11-dihydrodibenzo[b,f]thi...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1cccc(C)c1
Show InChI InChI=1S/C26H28N2S/c1-19-6-5-8-20(16-19)21-10-11-26-23(17-21)24(28-14-12-27(2)13-15-28)18-22-7-3-4-9-25(22)29-26/h3-11,16-17,24H,12-15,18H2,1-2H3
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0.950n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from bovine cloned alpha1a receptor expressed in BHK cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
ADRA1B


(C.H.O.)
BDBM50328491
PNG
(1-Methyl-4-(8-m-tolyl-10,11-dihydrodibenzo[b,f]thi...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1cccc(C)c1
Show InChI InChI=1S/C26H28N2S/c1-19-6-5-8-20(16-19)21-10-11-26-23(17-21)24(28-14-12-27(2)13-15-28)18-22-7-3-4-9-25(22)29-26/h3-11,16-17,24H,12-15,18H2,1-2H3
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0.950n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from hamster cloned alpha1b receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50328494
PNG
(1-(8-(2,5-Dimethylphenyl)-10,11-dihydrodibenzo[b,f...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1c(C)cccc1C
Show InChI InChI=1S/C27H30N2S/c1-19-7-6-8-20(2)27(19)22-11-12-26-23(17-22)24(29-15-13-28(3)14-16-29)18-21-9-4-5-10-25(21)30-26/h4-12,17,24H,13-16,18H2,1-3H3
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1n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from bovine cloned alpha1a receptor expressed in BHK cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50328487
PNG
(1-Methyl-4-(8-(pyridin-4-yl)-10,11-dihydrodibenzo[...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccncc1
Show InChI InChI=1S/C24H25N3S/c1-26-12-14-27(15-13-26)22-17-20-4-2-3-5-23(20)28-24-7-6-19(16-21(22)24)18-8-10-25-11-9-18/h2-11,16,22H,12-15,17H2,1H3
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1.10n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50328492
PNG
(1-Methyl-4-(8-p-tolyl-10,11-dihydrodibenzo[b,f]thi...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C26H28N2S/c1-19-7-9-20(10-8-19)21-11-12-26-23(17-21)24(28-15-13-27(2)14-16-28)18-22-5-3-4-6-25(22)29-26/h3-12,17,24H,13-16,18H2,1-2H3
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1.10n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from bovine cloned alpha1a receptor expressed in BHK cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
ADRA1B


(C.H.O.)
BDBM50328493
PNG
(1-(8-(2,3-Dimethylphenyl)-10,11-dihydrodibenzo[b,f...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1cccc(C)c1C
Show InChI InChI=1S/C27H30N2S/c1-19-7-6-9-23(20(19)2)21-11-12-27-24(17-21)25(29-15-13-28(3)14-16-29)18-22-8-4-5-10-26(22)30-27/h4-12,17,25H,13-16,18H2,1-3H3
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1.20n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from hamster cloned alpha1b receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50328493
PNG
(1-(8-(2,3-Dimethylphenyl)-10,11-dihydrodibenzo[b,f...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1cccc(C)c1C
Show InChI InChI=1S/C27H30N2S/c1-19-7-6-9-23(20(19)2)21-11-12-27-24(17-21)25(29-15-13-28(3)14-16-29)18-22-8-4-5-10-26(22)30-27/h4-12,17,25H,13-16,18H2,1-3H3
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1.5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from bovine cloned alpha1a receptor expressed in BHK cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50328487
PNG
(1-Methyl-4-(8-(pyridin-4-yl)-10,11-dihydrodibenzo[...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccncc1
Show InChI InChI=1S/C24H25N3S/c1-26-12-14-27(15-13-26)22-17-20-4-2-3-5-23(20)28-24-7-6-19(16-21(22)24)18-8-10-25-11-9-18/h2-11,16,22H,12-15,17H2,1H3
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1.5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from bovine cloned alpha1a receptor expressed in BHK cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50328490
PNG
(1-Methyl-4-(8-o-tolyl-10,11-dihydrodibenzo[b,f]thi...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccccc1C
Show InChI InChI=1S/C26H28N2S/c1-19-7-3-5-9-22(19)20-11-12-26-23(17-20)24(28-15-13-27(2)14-16-28)18-21-8-4-6-10-25(21)29-26/h3-12,17,24H,13-16,18H2,1-2H3
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1.60n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
ADRA1B


(C.H.O.)
BDBM50328495
PNG
(1-(8-Mesityl-10,11-dihydrodibenzo[b,f]thiepin-10-y...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C28H32N2S/c1-19-15-20(2)28(21(3)16-19)23-9-10-27-24(17-23)25(30-13-11-29(4)12-14-30)18-22-7-5-6-8-26(22)31-27/h5-10,15-17,25H,11-14,18H2,1-4H3
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1.80n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from hamster cloned alpha1b receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50328489
PNG
(1-Methyl-4-(8-phenyl-10,11-dihydrodibenzo[b,f]thie...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C25H26N2S/c1-26-13-15-27(16-14-26)23-18-21-9-5-6-10-24(21)28-25-12-11-20(17-22(23)25)19-7-3-2-4-8-19/h2-12,17,23H,13-16,18H2,1H3
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1.80n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
ADRA1B


(C.H.O.)
BDBM50328487
PNG
(1-Methyl-4-(8-(pyridin-4-yl)-10,11-dihydrodibenzo[...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccncc1
Show InChI InChI=1S/C24H25N3S/c1-26-12-14-27(15-13-26)22-17-20-4-2-3-5-23(20)28-24-7-6-19(16-21(22)24)18-8-10-25-11-9-18/h2-11,16,22H,12-15,17H2,1H3
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1.90n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from hamster cloned alpha1b receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50328493
PNG
(1-(8-(2,3-Dimethylphenyl)-10,11-dihydrodibenzo[b,f...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1cccc(C)c1C
Show InChI InChI=1S/C27H30N2S/c1-19-7-6-9-23(20(19)2)21-11-12-27-24(17-21)25(29-15-13-28(3)14-16-29)18-22-8-4-5-10-26(22)30-27/h4-12,17,25H,13-16,18H2,1-3H3
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2n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50328495
PNG
(1-(8-Mesityl-10,11-dihydrodibenzo[b,f]thiepin-10-y...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C28H32N2S/c1-19-15-20(2)28(21(3)16-19)23-9-10-27-24(17-23)25(30-13-11-29(4)12-14-30)18-22-7-5-6-8-26(22)31-27/h5-10,15-17,25H,11-14,18H2,1-4H3
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2n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from bovine cloned alpha1a receptor expressed in BHK cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50328491
PNG
(1-Methyl-4-(8-m-tolyl-10,11-dihydrodibenzo[b,f]thi...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1cccc(C)c1
Show InChI InChI=1S/C26H28N2S/c1-19-6-5-8-20(16-19)21-10-11-26-23(17-21)24(28-14-12-27(2)13-15-28)18-22-7-3-4-9-25(22)29-26/h3-11,16-17,24H,12-15,18H2,1-2H3
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3.40n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50328494
PNG
(1-(8-(2,5-Dimethylphenyl)-10,11-dihydrodibenzo[b,f...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1c(C)cccc1C
Show InChI InChI=1S/C27H30N2S/c1-19-7-6-8-20(2)27(19)22-11-12-26-23(17-22)24(29-15-13-28(3)14-16-29)18-21-9-4-5-10-25(21)30-26/h4-12,17,24H,13-16,18H2,1-3H3
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4.60n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50328495
PNG
(1-(8-Mesityl-10,11-dihydrodibenzo[b,f]thiepin-10-y...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C28H32N2S/c1-19-15-20(2)28(21(3)16-19)23-9-10-27-24(17-23)25(30-13-11-29(4)12-14-30)18-22-7-5-6-8-26(22)31-27/h5-10,15-17,25H,11-14,18H2,1-4H3
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4.90n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
ADRA1B


(C.H.O.)
BDBM50328490
PNG
(1-Methyl-4-(8-o-tolyl-10,11-dihydrodibenzo[b,f]thi...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccccc1C
Show InChI InChI=1S/C26H28N2S/c1-19-7-3-5-9-22(19)20-11-12-26-23(17-20)24(28-15-13-27(2)14-16-28)18-21-8-4-6-10-25(21)29-26/h3-12,17,24H,13-16,18H2,1-2H3
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4.90n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from hamster cloned alpha1b receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50328492
PNG
(1-Methyl-4-(8-p-tolyl-10,11-dihydrodibenzo[b,f]thi...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C26H28N2S/c1-19-7-9-20(10-8-19)21-11-12-26-23(17-21)24(28-15-13-27(2)14-16-28)18-22-5-3-4-6-25(22)29-26/h3-12,17,24H,13-16,18H2,1-2H3
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5.90n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from rat cloned alpha1d receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50328492
PNG
(1-Methyl-4-(8-p-tolyl-10,11-dihydrodibenzo[b,f]thi...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccc(C)cc1
Show InChI InChI=1S/C26H28N2S/c1-19-7-9-20(10-8-19)21-11-12-26-23(17-21)24(28-15-13-27(2)14-16-28)18-22-5-3-4-6-25(22)29-26/h3-12,17,24H,13-16,18H2,1-2H3
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6.30n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cells


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50328489
PNG
(1-Methyl-4-(8-phenyl-10,11-dihydrodibenzo[b,f]thie...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C25H26N2S/c1-26-13-15-27(16-14-26)23-18-21-9-5-6-10-24(21)28-25-12-11-20(17-22(23)25)19-7-3-2-4-8-19/h2-12,17,23H,13-16,18H2,1H3
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6.60n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from rat cloned alpha1d receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
ADRA1B


(C.H.O.)
BDBM50328494
PNG
(1-(8-(2,5-Dimethylphenyl)-10,11-dihydrodibenzo[b,f...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1c(C)cccc1C
Show InChI InChI=1S/C27H30N2S/c1-19-7-6-8-20(2)27(19)22-11-12-26-23(17-22)24(29-15-13-28(3)14-16-29)18-21-9-4-5-10-25(21)30-26/h4-12,17,24H,13-16,18H2,1-3H3
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6.90n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from hamster cloned alpha1b receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50328491
PNG
(1-Methyl-4-(8-m-tolyl-10,11-dihydrodibenzo[b,f]thi...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1cccc(C)c1
Show InChI InChI=1S/C26H28N2S/c1-19-6-5-8-20(16-19)21-10-11-26-23(17-21)24(28-14-12-27(2)13-15-28)18-22-7-3-4-9-25(22)29-26/h3-11,16-17,24H,12-15,18H2,1-2H3
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9.40n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from rat cloned alpha1d receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50328495
PNG
(1-(8-Mesityl-10,11-dihydrodibenzo[b,f]thiepin-10-y...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C28H32N2S/c1-19-15-20(2)28(21(3)16-19)23-9-10-27-24(17-23)25(30-13-11-29(4)12-14-30)18-22-7-5-6-8-26(22)31-27/h5-10,15-17,25H,11-14,18H2,1-4H3
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13n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from rat cloned alpha1d receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50328493
PNG
(1-(8-(2,3-Dimethylphenyl)-10,11-dihydrodibenzo[b,f...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1cccc(C)c1C
Show InChI InChI=1S/C27H30N2S/c1-19-7-6-9-23(20(19)2)21-11-12-27-24(17-21)25(29-15-13-28(3)14-16-29)18-22-8-4-5-10-26(22)30-27/h4-12,17,25H,13-16,18H2,1-3H3
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16n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from rat cloned alpha1d receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50328494
PNG
(1-(8-(2,5-Dimethylphenyl)-10,11-dihydrodibenzo[b,f...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1c(C)cccc1C
Show InChI InChI=1S/C27H30N2S/c1-19-7-6-8-20(2)27(19)22-11-12-26-23(17-22)24(29-15-13-28(3)14-16-29)18-21-9-4-5-10-25(21)30-26/h4-12,17,24H,13-16,18H2,1-3H3
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25n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from rat cloned alpha1d receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair
Alpha-1D adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50328490
PNG
(1-Methyl-4-(8-o-tolyl-10,11-dihydrodibenzo[b,f]thi...)
Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(cc12)-c1ccccc1C
Show InChI InChI=1S/C26H28N2S/c1-19-7-3-5-9-22(19)20-11-12-26-23(17-20)24(28-15-13-27(2)14-16-28)18-21-8-4-6-10-25(21)29-26/h3-12,17,24H,13-16,18H2,1-2H3
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32n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]prozosin from rat cloned alpha1d receptor


J Med Chem 53: 7021-34 (2010)

More data for this
Ligand-Target Pair