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5 similar compounds to monomer 50334194

Wt: 215.2
BDBM50334204
Wt: 235.6
BDBM50334207
Wt: 215.2
BDBM50334208
Wt: 215.2
BDBM50334196
Wt: 235.6
BDBM50334203

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50334204,50334207,50334208,50334196,50334203   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Imidazoline I1


(RAT)
BDBM50334196
PNG
(3-[(Imidazolidin-2-yl)imino]-4-methylindazole hydr...)
Show SMILES Cc1cccc2n[nH]c(N=C3NCCN3)c12
Show InChI InChI=1S/C11H13N5/c1-7-3-2-4-8-9(7)10(16-15-8)14-11-12-5-6-13-11/h2-4H,5-6H2,1H3,(H3,12,13,14,15,16)
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133n/an/an/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting


Bioorg Med Chem 19: 321-9 (2011)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334204
PNG
(3-[(Imidazolidin-2-yl)imino]-6-methylindazole hydr...)
Show SMILES Cc1ccc2c(N=C3NCCN3)[nH]nc2c1
Show InChI InChI=1S/C11H13N5/c1-7-2-3-8-9(6-7)15-16-10(8)14-11-12-4-5-13-11/h2-3,6H,4-5H2,1H3,(H3,12,13,14,15,16)
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325n/an/an/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting


Bioorg Med Chem 19: 321-9 (2011)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334203
PNG
(6-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...)
Show SMILES Clc1ccc2c(N=C3NCCN3)[nH]nc2c1
Show InChI InChI=1S/C10H10ClN5/c11-6-1-2-7-8(5-6)15-16-9(7)14-10-12-3-4-13-10/h1-2,5H,3-4H2,(H3,12,13,14,15,16)
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410n/an/an/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting


Bioorg Med Chem 19: 321-9 (2011)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334208
PNG
(3-[(Imidazolidin-2-yl)imino]-5-methylindazole hydr...)
Show SMILES Cc1ccc2n[nH]c(N=C3NCCN3)c2c1
Show InChI InChI=1S/C11H13N5/c1-7-2-3-9-8(6-7)10(16-15-9)14-11-12-4-5-13-11/h2-3,6H,4-5H2,1H3,(H3,12,13,14,15,16)
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1.02E+4n/an/an/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting


Bioorg Med Chem 19: 321-9 (2011)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334207
PNG
(5-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...)
Show SMILES Clc1ccc2n[nH]c(N=C3NCCN3)c2c1
Show InChI InChI=1S/C10H10ClN5/c11-6-1-2-8-7(5-6)9(16-15-8)14-10-12-3-4-13-10/h1-2,5H,3-4H2,(H3,12,13,14,15,16)
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9.30E+4n/an/an/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting


Bioorg Med Chem 19: 321-9 (2011)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334204
PNG
(3-[(Imidazolidin-2-yl)imino]-6-methylindazole hydr...)
Show SMILES Cc1ccc2c(N=C3NCCN3)[nH]nc2c1
Show InChI InChI=1S/C11H13N5/c1-7-2-3-8-9(6-7)15-16-10(8)14-11-12-4-5-13-11/h2-3,6H,4-5H2,1H3,(H3,12,13,14,15,16)
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n/an/a 1.66E+4n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membrane after 45 mins by liquid scintillation counting


Bioorg Med Chem 19: 321-9 (2011)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334203
PNG
(6-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...)
Show SMILES Clc1ccc2c(N=C3NCCN3)[nH]nc2c1
Show InChI InChI=1S/C10H10ClN5/c11-6-1-2-7-8(5-6)15-16-9(7)14-10-12-3-4-13-10/h1-2,5H,3-4H2,(H3,12,13,14,15,16)
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n/an/a 2.01E+3n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membrane after 45 mins by liquid scintillation counting


Bioorg Med Chem 19: 321-9 (2011)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334207
PNG
(5-Chloro-3-[(imidazolidin-2-yl)imino]indazole hydr...)
Show SMILES Clc1ccc2n[nH]c(N=C3NCCN3)c2c1
Show InChI InChI=1S/C10H10ClN5/c11-6-1-2-8-7(5-6)9(16-15-8)14-10-12-3-4-13-10/h1-2,5H,3-4H2,(H3,12,13,14,15,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membrane after 45 mins by liquid scintillation counting


Bioorg Med Chem 19: 321-9 (2011)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334196
PNG
(3-[(Imidazolidin-2-yl)imino]-4-methylindazole hydr...)
Show SMILES Cc1cccc2n[nH]c(N=C3NCCN3)c12
Show InChI InChI=1S/C11H13N5/c1-7-3-2-4-8-9(7)10(16-15-8)14-11-12-5-6-13-11/h2-4H,5-6H2,1H3,(H3,12,13,14,15,16)
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n/an/a 3.25E+4n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membrane after 45 mins by liquid scintillation counting


Bioorg Med Chem 19: 321-9 (2011)

More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50334196
PNG
(3-[(Imidazolidin-2-yl)imino]-4-methylindazole hydr...)
Show SMILES Cc1cccc2n[nH]c(N=C3NCCN3)c12
Show InChI InChI=1S/C11H13N5/c1-7-3-2-4-8-9(7)10(16-15-8)14-11-12-5-6-13-11/h2-4H,5-6H2,1H3,(H3,12,13,14,15,16)
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antibodypedia
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n/an/an/an/a 14n/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...


Bioorg Med Chem 19: 321-9 (2011)

More data for this
Ligand-Target Pair
Imidazoline I1


(RAT)
BDBM50334208
PNG
(3-[(Imidazolidin-2-yl)imino]-5-methylindazole hydr...)
Show SMILES Cc1ccc2n[nH]c(N=C3NCCN3)c2c1
Show InChI InChI=1S/C11H13N5/c1-7-2-3-9-8(6-7)10(16-15-9)14-11-12-4-5-13-11/h2-3,6H,4-5H2,1H3,(H3,12,13,14,15,16)
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n/an/a 2.12E+4n/an/an/an/an/an/a



Medical University of Gdansk

Curated by ChEMBL


Assay Description
Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membrane after 45 mins by liquid scintillation counting


Bioorg Med Chem 19: 321-9 (2011)

More data for this
Ligand-Target Pair