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20 similar compounds to monomer 50334528

Compile data set for download or QSAR
Wt: 288.3
BDBM50334517
Wt: 322.8
BDBM50334518
Wt: 372.3
BDBM50334519
Wt: 357.2
BDBM50334520
Wt: 356.3
BDBM50334521
Wt: 357.2
BDBM50334522
Wt: 333.3
BDBM50334523
Wt: 302.4
BDBM50334524
Wt: 344.4
BDBM50334525
Wt: 322.8
BDBM50334526
Wt: 306.3
BDBM50334527
Wt: 318.4
BDBM50334529
Wt: 304.3
BDBM50334530
Wt: 322.8
BDBM50334531
Wt: 322.8
BDBM50334532
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50334517,50334518,50334519,50334520,50334521,50334522,50334523,50334524,50334525,50334526,50334527,50334529,50334530,50334531,50334532   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334524
PNG
(1-benzyl-3-p-tolyl-4,5,6,7-tetrahydro-1H-pyrrolo[3...)
Show SMILES Cc1ccc(cc1)-c1cn(Cc2ccccc2)c2CCNCc12
Show InChI InChI=1S/C21H22N2/c1-16-7-9-18(10-8-16)20-15-23(14-17-5-3-2-4-6-17)21-11-12-22-13-19(20)21/h2-10,15,22H,11-14H2,1H3
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35n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334518
PNG
(1-benzyl-3-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-...)
Show SMILES Clc1ccc(cc1)-c1cn(Cc2ccccc2)c2CCNCc12
Show InChI InChI=1S/C20H19ClN2/c21-17-8-6-16(7-9-17)19-14-23(13-15-4-2-1-3-5-15)20-10-11-22-12-18(19)20/h1-9,14,22H,10-13H2
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107n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334521
PNG
(1-benzyl-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tet...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cn(Cc2ccccc2)c2CCNCc12
Show InChI InChI=1S/C21H19F3N2/c22-21(23,24)17-8-6-16(7-9-17)19-14-26(13-15-4-2-1-3-5-15)20-10-11-25-12-18(19)20/h1-9,14,25H,10-13H2
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167n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334517
PNG
(1-benzyl-3-phenyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,...)
Show SMILES C(c1ccccc1)n1cc(c2CNCCc12)-c1ccccc1
Show InChI InChI=1S/C20H20N2/c1-3-7-16(8-4-1)14-22-15-19(17-9-5-2-6-10-17)18-13-21-12-11-20(18)22/h1-10,15,21H,11-14H2
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220n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334529
PNG
(1-benzyl-3-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1H...)
Show SMILES COc1ccc(cc1)-c1cn(Cc2ccccc2)c2CCNCc12
Show InChI InChI=1S/C21H22N2O/c1-24-18-9-7-17(8-10-18)20-15-23(14-16-5-3-2-4-6-16)21-11-12-22-13-19(20)21/h2-10,15,22H,11-14H2,1H3
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290n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334523
PNG
(1-benzyl-3-(4-nitrophenyl)-4,5,6,7-tetrahydro-1H-p...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cn(Cc2ccccc2)c2CCNCc12
Show InChI InChI=1S/C20H19N3O2/c24-23(25)17-8-6-16(7-9-17)19-14-22(13-15-4-2-1-3-5-15)20-10-11-21-12-18(19)20/h1-9,14,21H,10-13H2
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450n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334522
PNG
(1-benzyl-3-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro...)
Show SMILES Clc1ccc(-c2cn(Cc3ccccc3)c3CCNCc23)c(Cl)c1
Show InChI InChI=1S/C20H18Cl2N2/c21-15-6-7-16(19(22)10-15)18-13-24(12-14-4-2-1-3-5-14)20-8-9-23-11-17(18)20/h1-7,10,13,23H,8-9,11-12H2
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2.07E+3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334527
PNG
(1-benzyl-3-(3-fluorophenyl)-4,5,6,7-tetrahydro-1H-...)
Show SMILES Fc1cccc(c1)-c1cn(Cc2ccccc2)c2CCNCc12
Show InChI InChI=1S/C20H19FN2/c21-17-8-4-7-16(11-17)19-14-23(13-15-5-2-1-3-6-15)20-9-10-22-12-18(19)20/h1-8,11,14,22H,9-10,12-13H2
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2.73E+3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334520
PNG
(1-benzyl-3-(3,4-dichlorophenyl)-4,5,6,7-tetrahydro...)
Show SMILES Clc1ccc(cc1Cl)-c1cn(Cc2ccccc2)c2CCNCc12
Show InChI InChI=1S/C20H18Cl2N2/c21-18-7-6-15(10-19(18)22)17-13-24(12-14-4-2-1-3-5-14)20-8-9-23-11-16(17)20/h1-7,10,13,23H,8-9,11-12H2
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4.47E+3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334532
PNG
(1-(3-chlorobenzyl)-3-phenyl-4,5,6,7-tetrahydro-1H-...)
Show SMILES Clc1cccc(Cn2cc(c3CNCCc23)-c2ccccc2)c1
Show InChI InChI=1S/C20H19ClN2/c21-17-8-4-5-15(11-17)13-23-14-19(16-6-2-1-3-7-16)18-12-22-10-9-20(18)23/h1-8,11,14,22H,9-10,12-13H2
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6.60E+3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334530
PNG
(4-(1-benzyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]py...)
Show SMILES Oc1ccc(cc1)-c1cn(Cc2ccccc2)c2CCNCc12
Show InChI InChI=1S/C20H20N2O/c23-17-8-6-16(7-9-17)19-14-22(13-15-4-2-1-3-5-15)20-10-11-21-12-18(19)20/h1-9,14,21,23H,10-13H2
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1.00E+4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334526
PNG
(1-benzyl-3-(3-chlorophenyl)-4,5,6,7-tetrahydro-1H-...)
Show SMILES Clc1cccc(c1)-c1cn(Cc2ccccc2)c2CCNCc12
Show InChI InChI=1S/C20H19ClN2/c21-17-8-4-7-16(11-17)19-14-23(13-15-5-2-1-3-6-15)20-9-10-22-12-18(19)20/h1-8,11,14,22H,9-10,12-13H2
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1.00E+4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334519
PNG
(1-benzyl-3-(4-(trifluoromethoxy)phenyl)-4,5,6,7-te...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cn(Cc2ccccc2)c2CCNCc12
Show InChI InChI=1S/C21H19F3N2O/c22-21(23,24)27-17-8-6-16(7-9-17)19-14-26(13-15-4-2-1-3-5-15)20-10-11-25-12-18(19)20/h1-9,14,25H,10-13H2
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1.00E+4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334525
PNG
(1-benzyl-3-(4-tert-butylphenyl)-4,5,6,7-tetrahydro...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cn(Cc2ccccc2)c2CCNCc12
Show InChI InChI=1S/C24H28N2/c1-24(2,3)20-11-9-19(10-12-20)22-17-26(16-18-7-5-4-6-8-18)23-13-14-25-15-21(22)23/h4-12,17,25H,13-16H2,1-3H3
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1.00E+4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50334531
PNG
(1-(2-chlorobenzyl)-3-phenyl-4,5,6,7-tetrahydro-1H-...)
Show SMILES Clc1ccccc1Cn1cc(c2CNCCc12)-c1ccccc1
Show InChI InChI=1S/C20H19ClN2/c21-19-9-5-4-8-16(19)13-23-14-18(15-6-2-1-3-7-15)17-12-22-11-10-20(17)23/h1-9,14,22H,10-13H2
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2.29E+4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]5-CT from rat recombinant 5HT7 receptor expressed in HEK293 cells after 60 mins


Bioorg Med Chem Lett 21: 42-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.078
BindingDB Entry DOI: 10.7270/Q2M908Z5
More data for this
Ligand-Target Pair