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12 similar compounds to monomer 50341572

Compile data set for download or QSAR
Wt: 472.0
BDBM50341564
Wt: 488.0
BDBM50341565
Wt: 487.0
BDBM50341566
Wt: 502.0
BDBM50341567
Wt: 506.4
BDBM50341568
Wt: 490.0
BDBM50341569
Wt: 472.0
BDBM50341570
Wt: 487.0
BDBM50341571
Wt: 501.0
BDBM50341573
Wt: 514.0
BDBM50341574
Wt: 432.9
BDBM50341578
Purchase
Wt: 468.5
BDBM50341580

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50341564,50341565,50341566,50341567,50341568,50341569,50341570,50341571,50341573,50341574,50341578,50341580   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341578
PNG
(3-[4-(3-Aminopropoxy)-7-chloro-3-(3,5-dimethylphen...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCCCN)-c1cccc(O)c1
Show InChI InChI=1S/C26H25ClN2O2/c1-16-9-17(2)11-19(10-16)23-15-29-25-14-24(27)21(18-5-3-6-20(30)12-18)13-22(25)26(23)31-8-4-7-28/h3,5-6,9-15,30H,4,7-8,28H2,1-2H3
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0.0250n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341574
PNG
(3-{7-Chloro-3-(3,5-dimethylphenyl)-4-[2-(piperidin...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C31H32ClN3O2/c1-19-13-20(2)15-23(14-19)27-18-35-29-17-28(32)25(21-6-8-22(9-7-21)31(33)36)16-26(29)30(27)37-12-10-24-5-3-4-11-34-24/h6-9,13-18,24,34H,3-5,10-12H2,1-2H3,(H2,33,36)/t24-/m1/s1
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0.0380n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341571
PNG
(4-[7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-pipe...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(O)cc1
Show InChI InChI=1S/C30H31ClN2O2/c1-19-13-20(2)15-22(14-19)27-18-33-29-17-28(31)25(21-6-8-24(34)9-7-21)16-26(29)30(27)35-12-10-23-5-3-4-11-32-23/h6-9,13-18,23,32,34H,3-5,10-12H2,1-2H3/t23-/m1/s1
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0.0800n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341573
PNG
(CHEMBL1766098 | {4-[7-Chloro-3-(3,5-dimethylphenyl...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(CO)cc1
Show InChI InChI=1S/C31H33ClN2O2/c1-20-13-21(2)15-24(14-20)28-18-34-30-17-29(32)26(23-8-6-22(19-35)7-9-23)16-27(30)31(28)36-12-10-25-5-3-4-11-33-25/h6-9,13-18,25,33,35H,3-5,10-12,19H2,1-2H3/t25-/m1/s1
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0.100n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341570
PNG
(7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-piperid...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccncc1
Show InChI InChI=1S/C29H30ClN3O/c1-19-13-20(2)15-22(14-19)26-18-33-28-17-27(30)24(21-6-10-31-11-7-21)16-25(28)29(26)34-12-8-23-5-3-4-9-32-23/h6-7,10-11,13-18,23,32H,3-5,8-9,12H2,1-2H3/t23-/m1/s1
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0.110n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341569
PNG
(7-Chloro-3-(3,5-dimethylphenyl)-6-(6-fluoropyridin...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(F)nc1
Show InChI InChI=1S/C29H29ClFN3O/c1-18-11-19(2)13-21(12-18)25-17-33-27-15-26(30)23(20-6-7-28(31)34-16-20)14-24(27)29(25)35-10-8-22-5-3-4-9-32-22/h6-7,11-17,22,32H,3-5,8-10H2,1-2H3/t22-/m1/s1
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0.120n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341564
PNG
(7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-piperid...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1cccnc1
Show InChI InChI=1S/C29H30ClN3O/c1-19-12-20(2)14-22(13-19)26-18-33-28-16-27(30)24(21-6-5-9-31-17-21)15-25(28)29(26)34-11-8-23-7-3-4-10-32-23/h5-6,9,12-18,23,32H,3-4,7-8,10-11H2,1-2H3/t23-/m1/s1
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0.130n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341580
PNG
(CHEMBL1766105 | [(4-{2-[(2R)-Piperidin-2-yl]ethoxy...)
Show SMILES OCc1cccc(c1)-c1ccc2ncc(-c3cccc(CO)c3)c(OCC[C@H]3CCCCN3)c2c1
Show InChI InChI=1S/C30H32N2O3/c33-19-21-5-3-7-23(15-21)24-10-11-29-27(17-24)30(35-14-12-26-9-1-2-13-31-26)28(18-32-29)25-8-4-6-22(16-25)20-34/h3-8,10-11,15-18,26,31,33-34H,1-2,9,12-14,19-20H2/t26-/m1/s1
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0.130n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341568
PNG
(7-Chloro-6-(6-chloropyridin-3-yl)-3-(3,5-dimethylp...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(Cl)nc1
Show InChI InChI=1S/C29H29Cl2N3O/c1-18-11-19(2)13-21(12-18)25-17-33-27-15-26(30)23(20-6-7-28(31)34-16-20)14-24(27)29(25)35-10-8-22-5-3-4-9-32-22/h6-7,11-17,22,32H,3-5,8-10H2,1-2H3/t22-/m1/s1
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0.130n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341565
PNG
(5-[7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-pipe...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(=O)[nH]c1
Show InChI InChI=1S/C29H30ClN3O2/c1-18-11-19(2)13-21(12-18)25-17-32-27-15-26(30)23(20-6-7-28(34)33-16-20)14-24(27)29(25)35-10-8-22-5-3-4-9-31-22/h6-7,11-17,22,31H,3-5,8-10H2,1-2H3,(H,33,34)/t22-/m1/s1
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0.270n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341566
PNG
(5-[7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-pipe...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(N)nc1
Show InChI InChI=1S/C29H31ClN4O/c1-18-11-19(2)13-21(12-18)25-17-33-27-15-26(30)23(20-6-7-28(31)34-16-20)14-24(27)29(25)35-10-8-22-5-3-4-9-32-22/h6-7,11-17,22,32H,3-5,8-10H2,1-2H3,(H2,31,34)/t22-/m1/s1
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0.600n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341567
PNG
(7-Chloro-3-(3,5-dimethylphenyl)-6-(6-methoxypyridi...)
Show SMILES COc1ccc(cn1)-c1cc2c(OCC[C@H]3CCCCN3)c(cnc2cc1Cl)-c1cc(C)cc(C)c1
Show InChI InChI=1S/C30H32ClN3O2/c1-19-12-20(2)14-22(13-19)26-18-33-28-16-27(31)24(21-7-8-29(35-3)34-17-21)15-25(28)30(26)36-11-9-23-6-4-5-10-32-23/h7-8,12-18,23,32H,4-6,9-11H2,1-3H3/t23-/m1/s1
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0.650n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341578
PNG
(3-[4-(3-Aminopropoxy)-7-chloro-3-(3,5-dimethylphen...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCCCN)-c1cccc(O)c1
Show InChI InChI=1S/C26H25ClN2O2/c1-16-9-17(2)11-19(10-16)23-15-29-25-14-24(27)21(18-5-3-6-20(30)12-18)13-22(25)26(23)31-8-4-7-28/h3,5-6,9-15,30H,4,7-8,28H2,1-2H3
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n/an/a 4.80n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assay


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341574
PNG
(3-{7-Chloro-3-(3,5-dimethylphenyl)-4-[2-(piperidin...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C31H32ClN3O2/c1-19-13-20(2)15-23(14-19)27-18-35-29-17-28(32)25(21-6-8-22(9-7-21)31(33)36)16-26(29)30(27)37-12-10-24-5-3-4-11-34-24/h6-9,13-18,24,34H,3-5,10-12H2,1-2H3,(H2,33,36)/t24-/m1/s1
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n/an/a 0.390n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assay


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341573
PNG
(CHEMBL1766098 | {4-[7-Chloro-3-(3,5-dimethylphenyl...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(CO)cc1
Show InChI InChI=1S/C31H33ClN2O2/c1-20-13-21(2)15-24(14-20)28-18-34-30-17-29(32)26(23-8-6-22(19-35)7-9-23)16-27(30)31(28)36-12-10-25-5-3-4-11-33-25/h6-9,13-18,25,33,35H,3-5,10-12,19H2,1-2H3/t25-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assay


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341571
PNG
(4-[7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-pipe...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(O)cc1
Show InChI InChI=1S/C30H31ClN2O2/c1-19-13-20(2)15-22(14-19)27-18-33-29-17-28(31)25(21-6-8-24(34)9-7-21)16-26(29)30(27)35-12-10-23-5-3-4-11-32-23/h6-9,13-18,23,32,34H,3-5,10-12H2,1-2H3/t23-/m1/s1
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n/an/a 0.380n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assay


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341570
PNG
(7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-piperid...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccncc1
Show InChI InChI=1S/C29H30ClN3O/c1-19-13-20(2)15-22(14-19)26-18-33-28-17-27(30)24(21-6-10-31-11-7-21)16-25(28)29(26)34-12-8-23-5-3-4-9-32-23/h6-7,10-11,13-18,23,32H,3-5,8-9,12H2,1-2H3/t23-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assay


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341569
PNG
(7-Chloro-3-(3,5-dimethylphenyl)-6-(6-fluoropyridin...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(F)nc1
Show InChI InChI=1S/C29H29ClFN3O/c1-18-11-19(2)13-21(12-18)25-17-33-27-15-26(30)23(20-6-7-28(31)34-16-20)14-24(27)29(25)35-10-8-22-5-3-4-9-32-22/h6-7,11-17,22,32H,3-5,8-10H2,1-2H3/t22-/m1/s1
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n/an/a 4.70n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assay


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341568
PNG
(7-Chloro-6-(6-chloropyridin-3-yl)-3-(3,5-dimethylp...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(Cl)nc1
Show InChI InChI=1S/C29H29Cl2N3O/c1-18-11-19(2)13-21(12-18)25-17-33-27-15-26(30)23(20-6-7-28(31)34-16-20)14-24(27)29(25)35-10-8-22-5-3-4-9-32-22/h6-7,11-17,22,32H,3-5,8-10H2,1-2H3/t22-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assay


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341567
PNG
(7-Chloro-3-(3,5-dimethylphenyl)-6-(6-methoxypyridi...)
Show SMILES COc1ccc(cn1)-c1cc2c(OCC[C@H]3CCCCN3)c(cnc2cc1Cl)-c1cc(C)cc(C)c1
Show InChI InChI=1S/C30H32ClN3O2/c1-19-12-20(2)14-22(13-19)26-18-33-28-16-27(31)24(21-7-8-29(35-3)34-17-21)15-25(28)30(26)36-11-9-23-6-4-5-10-32-23/h7-8,12-18,23,32H,4-6,9-11H2,1-3H3/t23-/m1/s1
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n/an/a 50n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assay


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341566
PNG
(5-[7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-pipe...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(N)nc1
Show InChI InChI=1S/C29H31ClN4O/c1-18-11-19(2)13-21(12-18)25-17-33-27-15-26(30)23(20-6-7-28(31)34-16-20)14-24(27)29(25)35-10-8-22-5-3-4-9-32-22/h6-7,11-17,22,32H,3-5,8-10H2,1-2H3,(H2,31,34)/t22-/m1/s1
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n/an/a 34n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assay


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341565
PNG
(5-[7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-pipe...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1ccc(=O)[nH]c1
Show InChI InChI=1S/C29H30ClN3O2/c1-18-11-19(2)13-21(12-18)25-17-32-27-15-26(30)23(20-6-7-28(34)33-16-20)14-24(27)29(25)35-10-8-22-5-3-4-9-31-22/h6-7,11-17,22,31H,3-5,8-10H2,1-2H3,(H,33,34)/t22-/m1/s1
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n/an/a 0.290n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assay


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341580
PNG
(CHEMBL1766105 | [(4-{2-[(2R)-Piperidin-2-yl]ethoxy...)
Show SMILES OCc1cccc(c1)-c1ccc2ncc(-c3cccc(CO)c3)c(OCC[C@H]3CCCCN3)c2c1
Show InChI InChI=1S/C30H32N2O3/c33-19-21-5-3-7-23(15-21)24-10-11-29-27(17-24)30(35-14-12-26-9-1-2-13-31-26)28(18-32-29)25-8-4-6-22(16-25)20-34/h3-8,10-11,15-18,26,31,33-34H,1-2,9,12-14,19-20H2/t26-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assay


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM50341564
PNG
(7-Chloro-3-(3,5-dimethylphenyl)-4-{2-[(2R)-piperid...)
Show SMILES Cc1cc(C)cc(c1)-c1cnc2cc(Cl)c(cc2c1OCC[C@H]1CCCCN1)-c1cccnc1
Show InChI InChI=1S/C29H30ClN3O/c1-19-12-20(2)14-22(13-19)26-18-33-28-16-27(30)24(21-6-5-9-31-17-21)15-25(28)29(26)34-11-8-23-7-3-4-10-32-23/h5-6,9,12-18,23,32H,3-4,7-8,10-11H2,1-2H3/t23-/m1/s1
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n/an/a 8.30n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP release after 40 mins by luminescence assay


J Med Chem 54: 2351-8 (2011)


Article DOI: 10.1021/jm101501b
BindingDB Entry DOI: 10.7270/Q2668DH8
More data for this
Ligand-Target Pair