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9 similar compounds to monomer 50351822

Compile data set for download or QSAR
Wt: 435.5
BDBM50342229
Wt: 460.5
BDBM50342230
Wt: 420.4
BDBM50351810
Wt: 448.5
BDBM50351811
Wt: 445.4
BDBM50351812
Wt: 473.5
BDBM50351813
Wt: 436.5
BDBM50351820
Wt: 464.5
BDBM50351821
Wt: 489.5
BDBM50351823

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50342229,50342230,50351810,50351811,50351812,50351813,50351820,50351821,50351823   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50342229
PNG
(2-(3-(6-Methylpyridin-2-yl)-4-(quinolin-6-yl)-1Hpy...)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2)cc1-c1ccc2ncccc2c1
Show InChI InChI=1S/C26H21N5S/c1-18-7-5-11-24(28-18)26-22(19-12-13-23-20(15-19)8-6-14-27-23)16-31(30-26)17-25(32)29-21-9-3-2-4-10-21/h2-16H,17H2,1H3,(H,29,32)
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n/an/a 94n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cells


Bioorg Med Chem 19: 2633-40 (2011)


Article DOI: 10.1016/j.bmc.2011.03.008
BindingDB Entry DOI: 10.7270/Q2639Q2H
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351823
PNG
(CHEMBL1824443)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2cccc(c2)C#N)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C28H23N7S/c1-17-6-4-9-25(30-17)28-23(21-10-11-24-26(13-21)32-19(3)18(2)31-24)15-35(34-28)16-27(36)33-22-8-5-7-20(12-22)14-29/h4-13,15H,16H2,1-3H3,(H,33,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50342229
PNG
(2-(3-(6-Methylpyridin-2-yl)-4-(quinolin-6-yl)-1Hpy...)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2)cc1-c1ccc2ncccc2c1
Show InChI InChI=1S/C26H21N5S/c1-18-7-5-11-24(28-18)26-22(19-12-13-23-20(15-19)8-6-14-27-23)16-31(30-26)17-25(32)29-21-9-3-2-4-10-21/h2-16H,17H2,1H3,(H,29,32)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as a substrate by radioisotopic protein kinase assay


Bioorg Med Chem 19: 2633-40 (2011)


Article DOI: 10.1016/j.bmc.2011.03.008
BindingDB Entry DOI: 10.7270/Q2639Q2H
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50342230
PNG
(CHEMBL1766454 | N-(3-Cyanophenyl)-2-(3-(6-methylpy...)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2cccc(c2)C#N)cc1-c1ccc2ncccc2c1
Show InChI InChI=1S/C27H20N6S/c1-18-5-2-9-25(30-18)27-23(20-10-11-24-21(14-20)7-4-12-29-24)16-33(32-27)17-26(34)31-22-8-3-6-19(13-22)15-28/h2-14,16H,17H2,1H3,(H,31,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as a substrate by radioisotopic protein kinase assay


Bioorg Med Chem 19: 2633-40 (2011)


Article DOI: 10.1016/j.bmc.2011.03.008
BindingDB Entry DOI: 10.7270/Q2639Q2H
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351810
PNG
(CHEMBL1824226)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2ccccc2)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6O/c1-17-6-5-9-22(28-17)25-20(18-10-11-21-23(14-18)27-13-12-26-21)15-31(30-25)16-24(32)29-19-7-3-2-4-8-19/h2-15H,16H2,1H3,(H,29,32)
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n/an/a 38n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351811
PNG
(CHEMBL1824227)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2ccccc2)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C27H24N6O/c1-17-8-7-11-24(28-17)27-22(20-12-13-23-25(14-20)30-19(3)18(2)29-23)15-33(32-27)16-26(34)31-21-9-5-4-6-10-21/h4-15H,16H2,1-3H3,(H,31,34)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351812
PNG
(CHEMBL1824432)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C#N)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H19N7O/c1-17-4-2-7-23(30-17)26-21(19-8-9-22-24(13-19)29-11-10-28-22)15-33(32-26)16-25(34)31-20-6-3-5-18(12-20)14-27/h2-13,15H,16H2,1H3,(H,31,34)
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n/an/a 153n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351813
PNG
(CHEMBL1824433)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C#N)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C28H23N7O/c1-17-6-4-9-25(30-17)28-23(21-10-11-24-26(13-21)32-19(3)18(2)31-24)15-35(34-28)16-27(36)33-22-8-5-7-20(12-22)14-29/h4-13,15H,16H2,1-3H3,(H,33,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351820
PNG
(CHEMBL1824440)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6S/c1-17-6-5-9-22(28-17)25-20(18-10-11-21-23(14-18)27-13-12-26-21)15-31(30-25)16-24(32)29-19-7-3-2-4-8-19/h2-15H,16H2,1H3,(H,29,32)
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n/an/a 13n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351821
PNG
(CHEMBL1824441)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C27H24N6S/c1-17-8-7-11-24(28-17)27-22(20-12-13-23-25(14-20)30-19(3)18(2)29-23)15-33(32-27)16-26(34)31-21-9-5-4-6-10-21/h4-15H,16H2,1-3H3,(H,31,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351823
PNG
(CHEMBL1824443)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2cccc(c2)C#N)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C28H23N7S/c1-17-6-4-9-25(30-17)28-23(21-10-11-24-26(13-21)32-19(3)18(2)31-24)15-35(34-28)16-27(36)33-22-8-5-7-20(12-22)14-29/h4-13,15H,16H2,1-3H3,(H,33,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351810
PNG
(CHEMBL1824226)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2ccccc2)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6O/c1-17-6-5-9-22(28-17)25-20(18-10-11-21-23(14-18)27-13-12-26-21)15-31(30-25)16-24(32)29-19-7-3-2-4-8-19/h2-15H,16H2,1H3,(H,29,32)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351811
PNG
(CHEMBL1824227)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2ccccc2)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C27H24N6O/c1-17-8-7-11-24(28-17)27-22(20-12-13-23-25(14-20)30-19(3)18(2)29-23)15-33(32-27)16-26(34)31-21-9-5-4-6-10-21/h4-15H,16H2,1-3H3,(H,31,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351812
PNG
(CHEMBL1824432)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C#N)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H19N7O/c1-17-4-2-7-23(30-17)26-21(19-8-9-22-24(13-19)29-11-10-28-22)15-33(32-26)16-25(34)31-20-6-3-5-18(12-20)14-27/h2-13,15H,16H2,1H3,(H,31,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351813
PNG
(CHEMBL1824433)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C#N)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C28H23N7O/c1-17-6-4-9-25(30-17)28-23(21-10-11-24-26(13-21)32-19(3)18(2)31-24)15-35(34-28)16-27(36)33-22-8-5-7-20(12-22)14-29/h4-13,15H,16H2,1-3H3,(H,33,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351820
PNG
(CHEMBL1824440)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6S/c1-17-6-5-9-22(28-17)25-20(18-10-11-21-23(14-18)27-13-12-26-21)15-31(30-25)16-24(32)29-19-7-3-2-4-8-19/h2-15H,16H2,1H3,(H,29,32)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50351821
PNG
(CHEMBL1824441)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C27H24N6S/c1-17-8-7-11-24(28-17)27-22(20-12-13-23-25(14-20)30-19(3)18(2)29-23)15-33(32-27)16-26(34)31-21-9-5-4-6-10-21/h4-15H,16H2,1-3H3,(H,31,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50342230
PNG
(CHEMBL1766454 | N-(3-Cyanophenyl)-2-(3-(6-methylpy...)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2cccc(c2)C#N)cc1-c1ccc2ncccc2c1
Show InChI InChI=1S/C27H20N6S/c1-18-5-2-9-25(30-18)27-23(20-10-11-24-21(14-20)7-4-12-29-24)16-33(32-27)17-26(34)31-22-8-3-6-19(13-22)15-28/h2-14,16H,17H2,1H3,(H,31,34)
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PC sid
UniChem

Similars

Article
PubMed
n/an/a 51n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cells


Bioorg Med Chem 19: 2633-40 (2011)


Article DOI: 10.1016/j.bmc.2011.03.008
BindingDB Entry DOI: 10.7270/Q2639Q2H
More data for this
Ligand-Target Pair