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5 similar compounds to monomer 50356880

Compile data set for download or QSAR
Wt: 264.3
BDBM50342989
Wt: 264.3
BDBM50342994
Wt: 264.3
BDBM50343000
Wt: 278.3
BDBM50356881
Wt: 248.3
BDBM50356883

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50342989,50342994,50343000,50356881,50356883   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356881
PNG
(CHEMBL1915537)
Show SMILES CNC1CN(C1)c1cc(NCCC(C)(C)C)nc(N)n1
Show InChI InChI=1S/C14H26N6/c1-14(2,3)5-6-17-11-7-12(19-13(15)18-11)20-8-10(9-20)16-4/h7,10,16H,5-6,8-9H2,1-4H3,(H3,15,17,18,19)
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PubMed
1.5n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas...


Bioorg Med Chem Lett 21: 6596-602 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.125
BindingDB Entry DOI: 10.7270/Q20C4W6C
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342989
PNG
(CHEMBL1771000 | N4-isobutyl-6-(4-methylpiperazin-1...)
Show SMILES CC(C)CNc1cc(nc(N)n1)N1CCN(C)CC1
Show InChI InChI=1S/C13H24N6/c1-10(2)9-15-11-8-12(17-13(14)16-11)19-6-4-18(3)5-7-19/h8,10H,4-7,9H2,1-3H3,(H3,14,15,16,17)
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2n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342994
PNG
((R)-N4-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NCC(C)C)nc(N)n1
Show InChI InChI=1S/C13H24N6/c1-9(2)7-16-11-6-12(18-13(14)17-11)19-5-4-10(8-19)15-3/h6,9-10,15H,4-5,7-8H2,1-3H3,(H3,14,16,17,18)/t10-/m1/s1
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4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356881
PNG
(CHEMBL1915537)
Show SMILES CNC1CN(C1)c1cc(NCCC(C)(C)C)nc(N)n1
Show InChI InChI=1S/C14H26N6/c1-14(2,3)5-6-17-11-7-12(19-13(15)18-11)20-8-10(9-20)16-4/h7,10,16H,5-6,8-9H2,1-4H3,(H3,15,17,18,19)
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4.60n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cells


Bioorg Med Chem Lett 21: 6596-602 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.125
BindingDB Entry DOI: 10.7270/Q20C4W6C
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343000
PNG
(CHEMBL1770985 | N2-isobutyl-6-(4-methylpiperazin-1...)
Show SMILES CC(C)CNc1nc(N)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C13H24N6/c1-10(2)9-15-13-16-11(14)8-12(17-13)19-6-4-18(3)5-7-19/h8,10H,4-7,9H2,1-3H3,(H3,14,15,16,17)
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15n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356883
PNG
(CHEMBL1915539)
Show SMILES CNC1CN(C1)c1cc(N)nc(NCC2CC2)n1
Show InChI InChI=1S/C12H20N6/c1-14-9-6-18(7-9)11-4-10(13)16-12(17-11)15-5-8-2-3-8/h4,8-9,14H,2-3,5-7H2,1H3,(H3,13,15,16,17)
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>2.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas...


Bioorg Med Chem Lett 21: 6596-602 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.125
BindingDB Entry DOI: 10.7270/Q20C4W6C
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356883
PNG
(CHEMBL1915539)
Show SMILES CNC1CN(C1)c1cc(N)nc(NCC2CC2)n1
Show InChI InChI=1S/C12H20N6/c1-14-9-6-18(7-9)11-4-10(13)16-12(17-11)15-5-8-2-3-8/h4,8-9,14H,2-3,5-7H2,1H3,(H3,13,15,16,17)
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PubMed
9.07E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cells


Bioorg Med Chem Lett 21: 6596-602 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.125
BindingDB Entry DOI: 10.7270/Q20C4W6C
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343000
PNG
(CHEMBL1770985 | N2-isobutyl-6-(4-methylpiperazin-1...)
Show SMILES CC(C)CNc1nc(N)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C13H24N6/c1-10(2)9-15-13-16-11(14)8-12(17-13)19-6-4-18(3)5-7-19/h8,10H,4-7,9H2,1-3H3,(H3,14,15,16,17)
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n/an/an/an/a 86n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342989
PNG
(CHEMBL1771000 | N4-isobutyl-6-(4-methylpiperazin-1...)
Show SMILES CC(C)CNc1cc(nc(N)n1)N1CCN(C)CC1
Show InChI InChI=1S/C13H24N6/c1-10(2)9-15-11-8-12(17-13(14)16-11)19-6-4-18(3)5-7-19/h8,10H,4-7,9H2,1-3H3,(H3,14,15,16,17)
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PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342994
PNG
((R)-N4-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NCC(C)C)nc(N)n1
Show InChI InChI=1S/C13H24N6/c1-9(2)7-16-11-6-12(18-13(14)17-11)19-5-4-10(8-19)15-3/h6,9-10,15H,4-5,7-8H2,1-3H3,(H3,14,16,17,18)/t10-/m1/s1
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PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair