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8 similar compounds to monomer 50306682

Wt: 409.2
BDBM50352551
Wt: 436.3
BDBM50352555
Wt: 493.3
BDBM50352556
Wt: 422.2
BDBM50352557
Wt: 436.3
BDBM50352558
Wt: 450.3
BDBM50352559
Wt: 451.3
BDBM50352560
Wt: 450.3
BDBM50352564
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50352551,50352555,50352556,50352557,50352558,50352559,50352560,50352564   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352559
PNG
(CHEMBL1825136)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCCNC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)4-5-17(24)20(19)23)30-18-7-13(8-27-21(18)25)14-9-28-29(11-14)15-3-2-6-26-10-15/h4-5,7-9,11-12,15,26H,2-3,6,10H2,1H3,(H2,25,27)
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14n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352556
PNG
(CHEMBL1825133)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(CC2CN(CC(N)=O)C2)c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C22H23Cl2FN6O2/c1-12(20-16(23)2-3-17(25)21(20)24)33-18-4-14(5-28-22(18)27)15-6-29-31(10-15)9-13-7-30(8-13)11-19(26)32/h2-6,10,12-13H,7-9,11H2,1H3,(H2,26,32)(H2,27,28)
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24n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352558
PNG
(CHEMBL1825135)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)[C@H]1CCNC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H20Cl2FN5O/c1-11(18-15(21)2-3-16(23)19(18)22)29-17-6-12(7-26-20(17)24)13-8-27-28(10-13)14-4-5-25-9-14/h2-3,6-8,10-11,14,25H,4-5,9H2,1H3,(H2,24,26)/t11?,14-/m0/s1
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26n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352557
PNG
(CHEMBL1825134)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CNC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C19H18Cl2FN5O/c1-10(17-14(20)2-3-15(22)18(17)21)28-16-4-11(5-25-19(16)23)12-6-26-27(9-12)13-7-24-8-13/h2-6,9-10,13,24H,7-8H2,1H3,(H2,23,25)
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35n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352551
PNG
(CHEMBL1821759)
Show SMILES CC(C)n1cc(cn1)-c1cnc(N)c(OC(C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C19H19Cl2FN4O/c1-10(2)26-9-13(8-25-26)12-6-16(19(23)24-7-12)27-11(3)17-14(20)4-5-15(22)18(17)21/h4-11H,1-3H3,(H2,23,24)
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37n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352560
PNG
(CHEMBL1825137)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCOCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H21Cl2FN4O2/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-26-21(18)25)14-10-27-28(11-14)15-4-6-29-7-5-15/h2-3,8-12,15H,4-7H2,1H3,(H2,25,26)
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38n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352555
PNG
(CHEMBL1825132)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(CC2CNC2)c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H20Cl2FN5O/c1-11(18-15(21)2-3-16(23)19(18)22)29-17-4-13(7-26-20(17)24)14-8-27-28(10-14)9-12-5-25-6-12/h2-4,7-8,10-12,25H,5-6,9H2,1H3,(H2,24,26)
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70n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352564
PNG
(CHEMBL1825141)
Show SMILES C[C@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m0/s1
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161n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
MutT homolog 1 protein (MTH1)


(Homo sapiens (Human))
BDBM50352564
PNG
(CHEMBL1825141)
Show SMILES C[C@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m0/s1
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n/an/a 330n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
EML4-ALK


(Homo sapiens (Human))
BDBM50352564
PNG
(CHEMBL1825141)
Show SMILES C[C@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m0/s1
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n/an/an/a 525n/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
MutT homolog 1 protein (MTH1)


(Homo sapiens (Human))
BDBM50352564
PNG
(CHEMBL1825141)
Show SMILES C[C@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m0/s1
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n/an/a 408n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
MutT homolog 1 protein (MTH1)


(Homo sapiens (Human))
BDBM50352564
PNG
(CHEMBL1825141)
Show SMILES C[C@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m0/s1
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n/an/a 330n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MTH1 expressed in Escherichia coli BL21 DE3 cells preincubated for 15 mins followed by 8-oxo-dGTP substrate addition ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352556
PNG
(CHEMBL1825133)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(CC2CN(CC(N)=O)C2)c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C22H23Cl2FN6O2/c1-12(20-16(23)2-3-17(25)21(20)24)33-18-4-14(5-28-22(18)27)15-6-29-31(10-15)9-13-7-30(8-13)11-19(26)32/h2-6,10,12-13H,7-9,11H2,1H3,(H2,26,32)(H2,27,28)
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n/an/a 53n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as inhibition of HGF-induced autophosphorylation by ELISA method


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352555
PNG
(CHEMBL1825132)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(CC2CNC2)c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H20Cl2FN5O/c1-11(18-15(21)2-3-16(23)19(18)22)29-17-4-13(7-26-20(17)24)14-8-27-28(10-14)9-12-5-25-6-12/h2-4,7-8,10-12,25H,5-6,9H2,1H3,(H2,24,26)
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n/an/a 45n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as inhibition of HGF-induced autophosphorylation by ELISA method


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352560
PNG
(CHEMBL1825137)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCOCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H21Cl2FN4O2/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-26-21(18)25)14-10-27-28(11-14)15-4-6-29-7-5-15/h2-3,8-12,15H,4-7H2,1H3,(H2,25,26)
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n/an/a 40n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as inhibition of HGF-induced autophosphorylation by ELISA method


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352559
PNG
(CHEMBL1825136)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CCCNC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)4-5-17(24)20(19)23)30-18-7-13(8-27-21(18)25)14-9-28-29(11-14)15-3-2-6-26-10-15/h4-5,7-9,11-12,15,26H,2-3,6,10H2,1H3,(H2,25,27)
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n/an/a 25n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as inhibition of HGF-induced autophosphorylation by ELISA method


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352558
PNG
(CHEMBL1825135)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)[C@H]1CCNC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H20Cl2FN5O/c1-11(18-15(21)2-3-16(23)19(18)22)29-17-6-12(7-26-20(17)24)13-8-27-28(10-13)14-4-5-25-9-14/h2-3,6-8,10-11,14,25H,4-5,9H2,1H3,(H2,24,26)/t11?,14-/m0/s1
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n/an/a 44n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as inhibition of HGF-induced autophosphorylation by ELISA method


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352564
PNG
(CHEMBL1825141)
Show SMILES C[C@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m0/s1
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n/an/an/a 38n/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352551
PNG
(CHEMBL1821759)
Show SMILES CC(C)n1cc(cn1)-c1cnc(N)c(OC(C)c2c(Cl)ccc(F)c2Cl)c1
Show InChI InChI=1S/C19H19Cl2FN4O/c1-10(2)26-9-13(8-25-26)12-6-16(19(23)24-7-12)27-11(3)17-14(20)4-5-15(22)18(17)21/h4-11H,1-3H3,(H2,23,24)
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n/an/a 36n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as inhibition of HGF-induced autophosphorylation by ELISA method


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50352557
PNG
(CHEMBL1825134)
Show SMILES CC(Oc1cc(cnc1N)-c1cnn(c1)C1CNC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C19H18Cl2FN5O/c1-10(17-14(20)2-3-15(22)18(17)21)28-16-4-11(5-25-19(16)23)12-6-26-27(9-12)13-7-24-8-13/h2-6,9-10,13,24H,7-8H2,1H3,(H2,23,25)
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n/an/a 59n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as inhibition of HGF-induced autophosphorylation by ELISA method


J Med Chem 54: 6342-63 (2011)

More data for this
Ligand-Target Pair