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15 similar compounds to monomer 50356852

Compile data set for download or QSAR
Wt: 333.8
BDBM50356875
Wt: 378.2
BDBM50356793
Wt: 378.2
BDBM50356796
Wt: 378.2
BDBM50356822
Wt: 333.8
BDBM50356823
Wt: 317.3
BDBM50356824
Wt: 378.2
BDBM50356825
Wt: 378.2
BDBM50356828
Wt: 333.8
BDBM50356829
Wt: 378.2
BDBM50356830
Wt: 333.8
BDBM50356831
Wt: 376.2
BDBM50356850
Wt: 331.8
BDBM50356851
Wt: 331.8
BDBM50356853
Wt: 365.3
BDBM50356854

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50356875,50356793,50356796,50356822,50356823,50356824,50356825,50356828,50356829,50356830,50356831,50356850,50356851,50356853,50356854   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356793
PNG
(CHEMBL1914760)
Show SMILES CN1CCN(CC1)c1nc(N)nc2c3cc(Br)ccc3sc12
Show InChI InChI=1S/C15H16BrN5S/c1-20-4-6-21(7-5-20)14-13-12(18-15(17)19-14)10-8-9(16)2-3-11(10)22-13/h2-3,8H,4-7H2,1H3,(H2,17,18,19)
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1n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356822
PNG
(CHEMBL1914788)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(Br)ccc3sc12
Show InChI InChI=1S/C15H16BrN5S/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m1/s1
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2.10n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356875
PNG
(CHEMBL1914792)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3ccc(Cl)cc3sc12
Show InChI InChI=1S/C15H16ClN5S/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-3-2-8(16)6-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m1/s1
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5.20n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356823
PNG
(CHEMBL1914789)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(Cl)ccc3sc12
Show InChI InChI=1S/C15H16ClN5S/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m1/s1
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10n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356825
PNG
(CHEMBL1914791)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3ccc(Br)cc3sc12
Show InChI InChI=1S/C15H16BrN5S/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-3-2-8(16)6-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m1/s1
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25n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356824
PNG
(CHEMBL1914790)
Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(F)ccc3sc12
Show InChI InChI=1S/C15H16FN5S/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m1/s1
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31n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356831
PNG
(CHEMBL1915020)
Show SMILES CN[C@H]1CCN(C1)c1nc(N)nc2c3ccc(Cl)cc3sc12
Show InChI InChI=1S/C15H16ClN5S/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-3-2-8(16)6-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m0/s1
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33n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356796
PNG
(CHEMBL1914762)
Show SMILES CN1CCN(CC1)c1nc(N)nc2c3ccc(Br)cc3sc12
Show InChI InChI=1S/C15H16BrN5S/c1-20-4-6-21(7-5-20)14-13-12(18-15(17)19-14)10-3-2-9(16)8-11(10)22-13/h2-3,8H,4-7H2,1H3,(H2,17,18,19)
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43n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356828
PNG
(CHEMBL1914795)
Show SMILES CN[C@H]1CCN(C1)c1nc(N)nc2c3cc(Br)ccc3sc12
Show InChI InChI=1S/C15H16BrN5S/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m0/s1
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65n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356829
PNG
(CHEMBL1914796)
Show SMILES CN[C@H]1CCN(C1)c1nc(N)nc2c3cc(Cl)ccc3sc12
Show InChI InChI=1S/C15H16ClN5S/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m0/s1
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76n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356830
PNG
(CHEMBL1914797)
Show SMILES CN[C@H]1CCN(C1)c1nc(N)nc2c3ccc(Br)cc3sc12
Show InChI InChI=1S/C15H16BrN5S/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-3-2-8(16)6-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m0/s1
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149n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356850
PNG
(CHEMBL1915039)
Show SMILES Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3ccc(Br)cc3c2n1
Show InChI InChI=1S/C15H14BrN5S/c16-7-1-2-11-10(3-7)12-13(22-11)14(20-15(17)19-12)21-6-8-4-9(21)5-18-8/h1-3,8-9,18H,4-6H2,(H2,17,19,20)/t8-,9-/m0/s1
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346n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356851
PNG
(CHEMBL1915040)
Show SMILES Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3ccc(Cl)cc3c2n1
Show InChI InChI=1S/C15H14ClN5S/c16-7-1-2-11-10(3-7)12-13(22-11)14(20-15(17)19-12)21-6-8-4-9(21)5-18-8/h1-3,8-9,18H,4-6H2,(H2,17,19,20)/t8-,9-/m0/s1
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837n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356853
PNG
(CHEMBL1915042)
Show SMILES Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3cc(Cl)ccc3c2n1
Show InChI InChI=1S/C15H14ClN5S/c16-7-1-2-10-11(3-7)22-13-12(10)19-15(17)20-14(13)21-6-8-4-9(21)5-18-8/h1-3,8-9,18H,4-6H2,(H2,17,19,20)/t8-,9-/m0/s1
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882n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50356854
PNG
(CHEMBL1915043)
Show SMILES Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3cc(ccc3c2n1)C(F)(F)F
Show InChI InChI=1S/C16H14F3N5S/c17-16(18,19)7-1-2-10-11(3-7)25-13-12(10)22-15(20)23-14(13)24-6-8-4-9(24)5-21-8/h1-3,8-9,21H,4-6H2,(H2,20,22,23)/t8-,9-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from recombinant human histamine H4 receptor


Bioorg Med Chem Lett 21: 6577-81 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.014
BindingDB Entry DOI: 10.7270/Q2CN749X
More data for this
Ligand-Target Pair